New synthetic phenylquinazoline derivatives induce apoptosis by targeting the pro-survival members of the BCL-2 family

Alpha-Mangostin Activates MOAP-1 Tumor Suppressor and Mitochondrial Signaling in MCF-7 Human Breast Cancer Cells

(2022) Samson Eugin Simon et al.   Evidence-based Complementary and Alternative Medicine

Emerging strategies for sensitization of therapy resistant tumors toward cancer therapeutics by targeting the Bcl-2 family, TGF-β, Wnt/β-Catenin, RASSF and miRNA regulated signaling pathways

(2021) Tarmarajen Veerasamy et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization

(2020) Jan Jamroskovic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tricistronic expression of MOAP-1, Bax and RASSF1A in cancer cells enhances chemo-sensitization that requires BH3L domain of MOAP-1

(2020) Yong Hoi Lee et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study

(2020) Federico Lucantoni et al.   CELL DEATH AND DIFFERENTIATION

Novel quinazolinone MJ‑33 induces AKT/mTOR‑mediated autophagy‑associated apoptosis in 5FU‑resistant colorectal cancer cells

(2020) Hai‑Anh Ha et al.   ONCOLOGY REPORTS

A Natural Quinazoline Derivative from Marine Sponge Hyrtios erectus Induces Apoptosis of Breast Cancer Cells via ROS Production and Intrinsic or Extrinsic Apoptosis Pathways

(2019) Arun Kumar De et al.   Marine Drugs

Bcl‑2 promotes metastasis through the epithelial‑to‑mesenchymal transition in the BCap37 medullary breast cancer cell line

(2018) Chengyong Du et al.   Oncology Letters

Identification, occurrence and activity of quinazoline alkaloids in Peganum harmala

(2017) Tomás Herraiz et al.   FOOD AND CHEMICAL TOXICOLOGY

BCL-XL overexpression promotes tumor progression-associated properties

(2017) Daniela Trisciuoglio et al.   Cell Death & Disease

Synthesis, characterization and biological evaluation of formononetin derivatives as novel EGFR inhibitors via inhibiting growth, migration and inducing apoptosis in breast cancer cell line

(2017) Hong-Yan Lin et al.   RSC Advances

Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes

(2016) Vicente Andreu-Fernández et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

(2015) Shundong Cang et al.   Journal of Hematology & Oncology

A new and facile CuCl2·2H2O-catalyzed one-pot three-component synthesis for quinazolines

(2015) Syed Muhammad Saad et al.   MONATSHEFTE FUR CHEMIE

The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics

(2015) A. N. Hata et al.   Cancer Discovery

Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres

(2014) Delyan P. Ivanov et al.   PLoS One

Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2)

(2013) Kapil Juvale et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance

(2013) H. Dai et al.   CANCER RESEARCH

Quinazoline derivatives: synthesis and bioactivities

(2013) Dan Wang et al.   Chemistry Central Journal

Synthesis and biological evaluation of crown ether fused quinazoline analogues as potent EGFR inhibitors

(2012) Shaojing Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Quinazoline derivatives as potential anticancer agents: a patent review (2007 – 2010)

(2012) Giovanni Marzaro et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides

(2012) Caterina Carmi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a quinazoline alkaloid produced byPenicillium vinaceum, an endophytic fungus fromCrocus sativus

(2011) Cheng-Jian Zheng et al.   PHARMACEUTICAL BIOLOGY

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

(2008) M Vogler et al.   CELL DEATH AND DIFFERENTIATION