Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres

How can attrition rates be reduced in cancer drug discovery?

(2013) Lucas Moreno et al.   Expert Opinion on Drug Discovery

Power and sample size

(2013) Martin Krzywinski et al.   NATURE METHODS

A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays

(2013) Grace Ka Yan Chan et al.   PLoS One

Multicellular Tumor Spheroids for Evaluation of Cytotoxicity and Tumor Growth Inhibitory Effects of Nanomedicines In Vitro: A Comparison of Docetaxel-Loaded Block Copolymer Micelles and Taxotere®

(2013) Andrew S. Mikhail et al.   PLoS One

Adjuvant Chemotherapy for Brain Tumors Delivered via a Novel Intra-Cavity Moldable Polymer Matrix

(2013) Cheryl V. Rahman et al.   PLoS One

Multi-cell type human liver microtissues for hepatotoxicity testing

(2012) S. Messner et al.   ARCHIVES OF TOXICOLOGY

Signaling mechanisms regulating adult neural stem cells and neurogenesis

(2012) Roland Faigle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

(2012) Maria Vinci et al.   BMC BIOLOGY

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast

(2012) Sophie Doublier et al.   BMC CANCER

Three-dimensional tissue cultures: current trends and beyond

(2012) Henry Page et al.   CELL AND TISSUE RESEARCH

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

A decade of change

(2012) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Reduced-dose craniospinal radiotherapy followed by tandem high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk medulloblastoma

(2012) K. W. Sung et al.   NEURO-ONCOLOGY

Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity

(2012) Marie-Gabrielle Zurich et al.   TOXICOLOGY IN VITRO

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

(2010) Yi-Chung Tung et al.   ANALYST

Monitoring of Cell Viability and Proliferation in Hydrogel-Encapsulated System by Resazurin Assay

(2010) Jing Xiao et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits

(2010) Heike Hardelauf et al.   LAB ON A CHIP

Medulloblastoma in childhood: revisiting intrathecal therapy in infants and children

(2009) Sharon Conroy et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Comparative Analysis of Gene Expression in Rat Liver Tissue and Monolayer- and Spheroid-Cultured Hepatocytes

(2009) Yusuke Sakai et al.   CELLS TISSUES ORGANS

Human Neurospheres as Three-Dimensional Cellular Systems for Developmental Neurotoxicity Testing

(2009) Michaela Moors et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

Medulloblastoma: new insights into biology and treatment

(2008) B Pizer et al.   Archives of Disease in Childhood-Education and Practice Edition

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Energy metabolism transition in multi-cellular human tumor spheroids

(2008) Sara Rodríguez-Enríquez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation

(2008) Xuan Fu et al.   PLoS One