Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

BH3 Mimetic ABT-737 Potentiates TRAIL-Mediated Apoptotic Signaling by Unsequestering Bim and Bak in Human Pancreatic Cancer Cells

(2008) S. Huang et al.   CANCER RESEARCH

Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)

(2008) M. Konopleva et al.   CANCER RESEARCH

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Therapeutic Efficacy of ABT-737, a Selective Inhibitor of BCL-2, in Small Cell Lung Cancer

(2008) C. L. Hann et al.   CANCER RESEARCH

A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells

(2008) M Vogler et al.   CELL DEATH AND DIFFERENTIATION

Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death

(2008) N Tajeddine et al.   ONCOGENE

Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons

(2008) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-Molecule Inhibitors of Bcl-2 Family Proteins as Therapeutic Agents in Cancer

(2008) Ramzi Mohammad et al.   Recent Patents on Anti-Cancer Drug Discovery

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY