Activating cannabinoid receptor 2 preserves axonal health through GSK-3β/NRF2 axis in adrenoleukodystrophy

Lipid Droplets in the Pathogenesis of Hereditary Spastic Paraplegia

(2021) Nimesha Tadepalle et al.   Frontiers in Molecular Biosciences

Sativex® (nabiximols) cannabinoid oromucosal spray in patients with resistant multiple sclerosis spasticity: the Belgian experience

(2021) Marie D’hooghe et al.   BMC Neurology

The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy

(2021) Laura Rodríguez-Pascau et al.   Science Translational Medicine

A double-blind, placebo-controlled, randomized trial of PXT3003 for the treatment of Charcot–Marie–Tooth type 1A

(2021) Shahram Attarian et al.   Orphanet Journal of Rare Diseases

Biological basis of cannabinoid medicines

(2021) Erik Keimpema et al.   SCIENCE

Integrated Management of Multiple Sclerosis Spasticity and Associated Symptoms Using the Spasticity-Plus Syndrome Concept: Results of a Structured Specialists' Discussion Using the Workmat® Methodology

(2021) Oscar Fernandez et al.   Frontiers in Neurology

The peroxisomal fatty acid transporter ABCD1/PMP-4 is required in the C. elegans hypodermis for axonal maintenance: A worm model for adrenoleukodystrophy

(2020) Andrea Coppa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel approaches and current challenges with targeting the endocannabinoid system

(2020) Paula Morales et al.   Expert Opinion on Drug Discovery

Effects of THC/CBD oromucosal spray on spasticity-related symptoms in people with multiple sclerosis: results from a retrospective multicenter study

(2020) Francesco Patti et al.   NEUROLOGICAL SCIENCES

Safety and efficacy of lenabasum in a phase 2 randomized, placebo‐controlled trial in adults with systemic sclerosis

(2020) Robert Spiera et al.   Arthritis & Rheumatology

High‐dose biotin restores redox balance, energy and lipid homeostasis, and axonal health in a model of adrenoleukodystrophy

(2020) Stéphane Fourcade et al.   BRAIN PATHOLOGY

Adrenoleukodystrophy Newborn Screening in the Netherlands (SCAN Study): The X-Factor

(2020) Rinse W. Barendsen et al.   Frontiers in Cell and Developmental Biology

Safety and efficacy of lenabasum in a phase 2 randomized, placebo-controlled trial in adults with cystic fibrosis

(2020) James F. Chmiel et al.   Journal of Cystic Fibrosis

MRI surveillance of boys with X‐linked adrenoleukodystrophy identified by newborn screening: Meta‐analysis and consensus guidelines

(2020) Eric J. Mallack et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Allogeneic hematopoietic stem cell transplantation with myeloablative conditioning for adult cerebral X-linked adrenoleukodystrophy

(2019) Nils Waldhüter et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Microglia damage precedes major myelin breakdown in X-linked adrenoleukodystrophy and metachromatic leukodystrophy

(2019) Caroline G. Bergner et al.   GLIA

Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome

(2019) Alba Navarro-Romero et al.   NEUROBIOLOGY OF DISEASE

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

(2019) Chi-Lun Chang et al.   JOURNAL OF CELL BIOLOGY

Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study

(2019) Carlos Casasnovas et al.   Neurotherapeutics

Cannabinoid CB2 Receptor Modulation by the Transcription Factor NRF2 is Specific in Microglial Cells

(2019) M. Galán-Ganga et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cannabinoids and the expanded endocannabinoid system in neurological disorders

(2019) Luigia Cristino et al.   Nature Reviews Neurology

Targeting glial cannabinoid CB2 receptors to delay the progression of the pathological phenotype in TDP-43 (A315T) transgenic mice, a model of amyotrophic lateral sclerosis

(2018) Francisco Espejo-Porras et al.   BRITISH JOURNAL OF PHARMACOLOGY

Emerging Links between Lipid Droplets and Motor Neuron Diseases

(2018) Giuseppa Pennetta et al.   DEVELOPMENTAL CELL

Aberrant regulation of the GSK‐3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy

(2018) Pablo Ranea‐Robles et al.   EMBO Molecular Medicine

Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease

(2018) Alicia López et al.   Journal of Neuroinflammation

Cannabinoid CB1 and CB2 Receptors, and Monoacylglycerol Lipase Gene Expression Alterations in the Basal Ganglia of Patients with Parkinson’s Disease

(2018) Francisco Navarrete et al.   Neurotherapeutics

Analysis of endocannabinoid receptors and enzymes in the post-mortem motor cortex and spinal cord of amyotrophic lateral sclerosis patients

(2018) Francisco Espejo-Porras et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Newborn Screening and Emerging Therapies for X-Linked Adrenoleukodystrophy

(2018) Ann B. Moser et al.   JAMA Neurology

CB2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice

(2018) Ester Aso et al.   JOURNAL OF ALZHEIMERS DISEASE

HIV

(2018) Jade Ghosn et al.   LANCET

New approaches and challenges to targeting the endocannabinoid system

(2018) Vincenzo Di Marzo   NATURE REVIEWS DRUG DISCOVERY

2-arachidonoylglycerol reduces proteoglycans and enhances remyelination in a progressive model of demyelination

(2017) A Feliu et al.   JOURNAL OF NEUROSCIENCE

Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy

(2017) Florian Eichler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain

(2017) Sangdon Han et al.   ACS Medicinal Chemistry Letters

Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy

(2016) Nathalie Launay et al.   ACTA NEUROPATHOLOGICA

Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation

(2016) F. Rossi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adrenoleukodystrophy – neuroendocrine pathogenesis and redefinition of natural history

(2016) Stephan Kemp et al.   Nature Reviews Endocrinology

Microglia activation states and cannabinoid system: Therapeutic implications

(2016) M. Mecha et al.   PHARMACOLOGY & THERAPEUTICS

Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila

(2015) Andrew P. Bailey et al.   CELL

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy

(2015) L Morató et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration

(2015) Stéphane Fourcade et al.   FREE RADICAL BIOLOGY AND MEDICINE

Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy

(2015) Montserrat Ruiz et al.   HUMAN MOLECULAR GENETICS

Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy

(2014) Nathalie Launay et al.   ACTA NEUROPATHOLOGICA

Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelinationin vivo

(2014) Ana Bernal-Chico et al.   GLIA

The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase

(2014) J. M. Inloes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy

(2013) Laia Morató et al.   BRAIN

Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS

(2013) Weimin Kong et al.   CELLULAR IMMUNOLOGY

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

(2013) J. López-Erauskin et al.   HUMAN MOLECULAR GENETICS

Therapeutic Utility of Cannabinoid Receptor Type 2 (CB2) Selective Agonists

(2013) Sangdon Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Conserved Role for Atlastin GTPases in Regulating Lipid Droplet Size

(2013) Robin W. Klemm et al.   Cell Reports

Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?

(2012) Elena Galea et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy

(2012) Jone López-Erauskin et al.   BRAIN

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice

(2012) J. Xu et al.   DIABETES

Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice

(2012) Ana María Martín-Moreno et al.   Journal of Neuroinflammation

Cannabinoid Receptor 2 Signaling in Peripheral Immune Cells Modulates Disease Onset and Severity in Mouse Models of Huntington's Disease

(2012) J. Bouchard et al.   JOURNAL OF NEUROSCIENCE

Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy

(2011) Jone López-Erauskin et al.   ANNALS OF NEUROLOGY

Oxidative Damage Compromises Energy Metabolism in the Axonal Degeneration Mouse Model of X-Adrenoleukodystrophy

(2011) Jorge Galino et al.   ANTIOXIDANTS & REDOX SIGNALING

Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy

(2011) Agatha Schlüter et al.   HUMAN MOLECULAR GENETICS

Pathomechanisms Underlying X-Adrenoleukodystrophy: A Three-Hit Hypothesis

(2010) Inderjit Singh et al.   BRAIN PATHOLOGY

Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age

(2010) J. Agudo et al.   DIABETOLOGIA

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity

(2009) Javier Palazuelos et al.   BRAIN

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

(2009) N. Cartier et al.   SCIENCE

A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis

(2008) Stéphane Fourcade et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?

(2008) Florian S. Eichler et al.   ANNALS OF NEUROLOGY

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

(2008) S. Fourcade et al.   HUMAN MOLECULAR GENETICS

Cannabinoid CB2receptors in human brain inflammation

(2007) C Benito et al.   BRITISH JOURNAL OF PHARMACOLOGY