Editorial Material
Urology & Nephrology
Volker H. Haase
Summary: This article introduces the clinical application of ferric citrate and demonstrates through genetic models that the iron delivery by ferric citrate depends on ferroportin expression rather than paracellular iron transport.
KIDNEY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Christina Kiel, David Matallanas, Walter Kolch
Summary: RAS oncogenes, commonly mutated in human cancers, control various cellular functions and their signaling is altered in over half of human cancers. Recent efforts in detailed molecular studies, large-scale omics studies, and computational modeling are providing a comprehensive understanding of RAS signaling, paving the way for new mechanism-based therapies for RAS mutated cancers.
Review
Immunology
Ari B. Molofsky, Richard M. Locksley
Summary: Type 2 immunity is mediated by a group of cytokines primarily produced by innate lymphoid cells (group 2) and their adaptive counterparts, CD4+ helper type 2 cells. These cytokines and cells work together to maintain the barriers of epithelial tissues and relay information to the adaptive immune system. Allergic pathology can occur when there are deviations in local sustaining units due to environmental effects and genetic mutations. Understanding type 2 immunity is crucial for tissue repair, regeneration, and the development of allergic diseases.
Review
Cell Biology
Amy B. P. Ribet, Pei Ying Ng, Nathan J. Pavlos
Summary: Osteoclasts play a crucial role in bone resorption, maintaining extreme environmental conditions and coordinating the actions of various membrane transport proteins. In addition to well-known key proteins, the contributions of other membrane transport proteins to osteoclast function are still unclear.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Adam Nathan McShane, Dessislava Malinova
Summary: This review summarizes the current understanding of B cell antigen uptake mechanisms, their relevance to pathology, and the remaining questions in the field. The internalization of antigens through B cell receptors plays a critical role in initiating immune responses and is also associated with autoimmune disorders and malignancies. However, the molecular mechanisms underlying BCR endocytosis are still largely unknown. This review discusses recent advancements in this area and highlights the potential therapeutic opportunities.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Jean M. Kanellopoulos, David M. Ojcius
Summary: This special edition provides a summary of significant progress in understanding signaling by T lymphocytes. It explores the changes in T cell adhesion and actin cytoskeleton during interactions with antigen-presenting cells (APCs) and other immune cells. The articles discuss the mediators of these changes within T cells and on the T cell surface. They specifically focus on inside-out integrin signaling, components of the immunological synapse, T cell receptor signaling from endosomes, membrane transfer between APCs and T cells via trogocytosis, immune deficiencies in T cell signaling pathways, and the role of THEMIS in thymocyte development and peripheral T cell function.
BIOMEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Feng Yuan, Christopher T. Lee, Arjun Sangani, Justin R. Houser, Liping Wang, Eileen M. Lafer, Padmini Rangamani, Jeanne C. Stachowiak
Summary: Membrane curvature is crucial for cellular functions and recent studies have revealed the role of intrinsically disordered proteins in driving membrane bending. Repulsive interactions among disordered domains lead to convex curvature, while attractive interactions result in concave curvature, forming membrane-bound liquid-like condensates. This study investigates the effects of disordered domains containing both repulsive and attractive interactions on curvature. The findings show that the position of the attractive or repulsive domain relative to the membrane determines the curvature, with increasing ionic strength altering the transition from convex to concave. These results provide design rules for membrane bending by disordered proteins.
Review
Endocrinology & Metabolism
Shauni L. Geeraerts, Elien Heylen, Kim De Keersmaecker, Kim R. Kampen
Summary: Cancer cells reprogram their metabolism to hyperactivate serine and glycine synthesis, relying on de novo production and genetic alterations to enhance their survival and proliferation. Serine and glycine synthesis play a crucial role in cancer progression, contributing to macromolecule synthesis, oxidative stress neutralization, and regulation of biological processes like methylation.
Article
Biochemical Research Methods
Roland G. Huber, Jan K. Marzinek, Priscilla L. S. Boon, Wan Yue, Peter J. Bond
Summary: Study on enveloped viruses such as flaviviruses plays a crucial role in understanding their infective mechanisms, with computational modeling providing insights into their molecular basis. These efforts can lead to the development of new antiviral therapeutics and vaccine strategies targeting enveloped viruses.
Article
Biochemistry & Molecular Biology
Tamas Hegedus, Markus Geisler, Gergely Laszlo Lukacs, Bianka Farkas
Summary: Transmembrane (TM) proteins are important drug targets, and the AlphaFold2 machine learning method greatly improves the prediction of their structures. However, the reliability of AlphaFold2's predictions for TM proteins needs to be assessed. The results of this study suggest that AlphaFold2 performs well for TM proteins and its application will advance research in this area.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Editorial Material
Cell Biology
Eva Maria Wenzel, Camilla Raiborg
Summary: In this study, the researchers explore how secretory endosomes are guided by ER-endosome contacts to undergo cellular detour and multiple identity transitions for efficient exosome release.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Business
Bernard Cova, Bjoern Sven Ivens, Robert Spencer
Summary: This paper addresses the inadequate consideration of the negative consequences of market shaping on non-focal actors, particularly in terms of exclusion. By analyzing 'cold case' data, a typology of actor responses in exclusionary market situations is proposed, highlighting the relative absence of total exclusion and shifting the focus from the dark side to the downside of market shaping.
JOURNAL OF BUSINESS RESEARCH
(2021)
Review
Critical Care Medicine
David A. Kaufman, Marcela Lopes, Niharika Maviya, Sheldon A. Magder
Summary: IV fluid administration is a common intervention for critically ill patients, with many unanswered questions and future research needing to include a physiological understanding of IVF in study design.
CRITICAL CARE MEDICINE
(2023)
Editorial Material
Immunology
Andre Perez-Potti, Joshua Lange, Marcus Buggert
Summary: The comprehensive analysis of specific and cross-reactive SARS-CoV-2 epitopes revealed functional T cell responses against specific viral regions in essentially all convalescent individuals and a majority of unexposed donors, indicating that cross-reactive responses to COVID-19 are widespread and play a crucial role in the antiviral process.
Review
Microbiology
Colin R. Harwood, Yoshimi Kikuchi
Summary: Most bacteria reproduce by binary fission and may be considered immortal, although they age due to damage to DNA and proteins. DNA damage can often be repaired, but proteins have a functional lifespan and require specific degradation processes. Proteases play crucial roles in various cellular functions in different parts of the cell.
FEMS MICROBIOLOGY REVIEWS
(2022)