As We Drink and Breathe: Adverse Health Effects of Microcystins and Other Harmful Algal Bloom Toxins in the Liver, Gut, Lungs and Beyond

Identification of Novel Microcystins Using High-Resolution MS and MSn with Python Code

(2022) David Baliu-Rodriguez et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

CyanoMetDB, a comprehensive public database of secondary metabolites from cyanobacteria

(2021) Martin R. Jones et al.   WATER RESEARCH

Cytotoxic and Genotoxic Effects of Cyanobacterial and Algal Extracts—Microcystin and Retinoic Acid Content

(2021) Michal Bittner et al.   Toxins

Multibiomarker-based assessment of toxicity of central European strains of filamentous cyanobacteria Aphanizomenon gracile and Raphidiopsis raciborskii to zebrafish Danio rerio

(2021) Halina Falfushynska et al.   WATER RESEARCH

Microcystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages

(2021) Robin C. Su et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Variability in microcystin quotas during a Microcystis bloom in a eutrophic lake

(2021) Susanna A. Wood et al.   PLoS One

Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans

(2021) Tarana Arman et al.   Toxins

Novel high throughput sequencing - fluorometric approach demonstrates Microcystis blooms across western Lake Erie are promoted by grazing resistance and nutrient enhanced growth

(2021) Megan Ladds et al.   HARMFUL ALGAE

The Natural Products Atlas 2.0: a database of microbially-derived natural products

(2021) Jeffrey A van Santen et al.   NUCLEIC ACIDS RESEARCH

MCLR-elicited hepatic fibrosis and carcinogenic gene expression changes persist in rats with diet-induced nonalcoholic steatohepatitis through a 4-week recovery period

(2021) Tarana Arman et al.   TOXICOLOGY

Toward Revealing Microcystin Distribution in Mouse Liver Tissue Using MALDI-MS Imaging

(2021) Daria Kucheriavaia et al.   Toxins

Dark side of cyanobacteria: searching for strategies to control blooms

(2021) María José Huertas et al.   Microbial Biotechnology

Exposure to microcystin among coastal residents during a cyanobacteria bloom in Florida

(2020) Adam M. Schaefer et al.   HARMFUL ALGAE

Nitrogen flux into metabolites and microcystins changes in response to different nitrogen sources in Microcystis aeruginosa NIES ‐843

(2020) Lauren E. Krausfeldt et al.   ENVIRONMENTAL MICROBIOLOGY

Harmful Algal Bloom Toxins in Aerosol Generated from Inland Lake Water

(2020) Nicole E. Olson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Development and Application of Extraction Methods for LC-MS Quantification of Microcystins in Liver Tissue

(2020) David Baliu-Rodriguez et al.   Toxins

Harmful Algal Bloom Toxicity in Lithobates catesbeiana Tadpoles

(2020) Robin C. Su et al.   Toxins

CD40 Receptor Knockout Protects against Microcystin-LR (MC-LR) Prolongation and Exacerbation of Dextran Sulfate Sodium (DSS)-Induced Colitis

(2020) Robin C. Su et al.   Biomedicines

Assessment of diagnostic biomarkers of liver injury in the setting of microcystin-LR (MC-LR) hepatotoxicity

(2020) Robin C. Su et al.   CHEMOSPHERE

Microcystins and Microcystis aeruginosa PCC7806 extracts modulate steroidogenesis differentially in the human H295R adrenal model

(2020) Vittoria Mallia et al.   PLoS One

Genotoxic Effects of Cylindrospermopsin, Microcystin-LR and Their Binary Mixture in Human Hepatocellular Carcinoma (HepG2) Cell Line

(2020) Leticia Díez-Quijada et al.   Toxins

Surveillance for Harmful Algal Bloom Events and Associated Human and Animal Illnesses — One Health Harmful Algal Bloom System, United States, 2016–2018

(2020) Virginia A. Roberts et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity

(2019) John D. Clarke et al.   TOXICON

Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis in Rats

(2019) Tarana Arman et al.   Toxins

Exposure to the Harmful Algal Bloom (HAB) Toxin Microcystin-LR (MC-LR) Prolongs and Increases Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis

(2019) Robin C. Su et al.   Toxins

Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease

(2019) Apurva Lad et al.   Toxins

Hyperglycemia induces key genetic and phenotypic changes in human liver epithelial HepG2 cells which parallel the Leprdb/J mouse model of non-alcoholic fatty liver disease (NAFLD)

(2019) Robin C. Su et al.   PLoS One

Interactions between nitrogen form, loading rate, and light intensity on Microcystis and Planktothrix growth and microcystin production

(2018) Justin D. Chaffin et al.   HARMFUL ALGAE

Solid-phase extraction, quantification, and selective determination of microcystins in water with a gold-polypyrrole nanocomposite sorbent material

(2018) Amila M. Devasurendra et al.   JOURNAL OF CHROMATOGRAPHY A

Uptake and accumulation of Microcystin-LR based on exposure through drinking water: An animal model assessing the human health risk

(2018) Brett Greer et al.   Scientific Reports

Unexpected Contributions of Sea Spray and Lake Spray Aerosol to Inland Particulate Matter

(2018) Nathaniel W. May et al.   Environmental Science & Technology Letters

Development and applications of solid-phase extraction and liquid chromatography-mass spectrometry methods for quantification of microcystins in urine, plasma, and serum

(2018) Dilrukshika S.W. Palagama et al.   JOURNAL OF CHROMATOGRAPHY A

Isolation and characterization of Lake Erie bacteria that degrade the cyanobacterial microcystin toxin MC-LR

(2018) Alison Thees et al.   JOURNAL OF GREAT LAKES RESEARCH

Aerosol Emissions from Great Lakes Harmful Algal Blooms

(2017) Nathaniel W. May et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Microcystin exposure Exacerbates Non-alcoholic Fatty Liver Disease (NAFLD) via NOX2 Dependent Activation of miR21-induced Inflammatory Pathways

(2017) Muayad Albadrani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effects of a cocktail of lactic acid bacteria on microcystin-LR-induced hepatotoxicity and oxidative damage in BALB/c mice

(2017) Jichun Zhao et al.   RSC Advances

Variable Cyanobacterial Toxin and Metabolite Profiles across Six Eutrophic Lakes of Differing Physiochemical Characteristics

(2017) Lucas Beversdorf et al.   Toxins

Adsorption of Ten Microcystin Congeners to Common Laboratory-Ware Is Solvent and Surface Dependent

(2017) Stefan Altaner et al.   Toxins

Detection of Cyanotoxins in Algae Dietary Supplements

(2017) Audrey Roy-Lachapelle et al.   Toxins

Toxic mechanisms of microcystins in mammals

(2017) Nicole L. McLellan et al.   Toxicology Research

Prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the United States

(2017) Michael H. Le et al.   PLoS One

Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study

(2016) Jun He et al.   ARCHIVES OF TOXICOLOGY

Risk to human health associated with the environmental occurrence of cyanobacterial neurotoxic alkaloids anatoxins and saxitoxins

(2016) Emanuela Testai et al.   CRITICAL REVIEWS IN TOXICOLOGY

Determination of Environmental Exposure to Microcystin and Aflatoxin as a Risk for Renal Function Based on 5493 Rural People in Southwest China

(2016) Hui Lin et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

A review of the global ecology, genomics, and biogeography of the toxic cyanobacterium, Microcystis spp.

(2016) Matthew J. Harke et al.   HARMFUL ALGAE

Preface for Special Issue on “Global expansion of harmful cyanobacterial blooms: Diversity, ecology, causes, and controls”

(2016) Timothy W. Davis et al.   HARMFUL ALGAE

Epidemiology and natural history of non-alcoholic fatty liver disease

(2016) Yousef Fazel et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2016) Gregory Thomas Brown et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Prevalence of Inflammatory Bowel Disease Among Adults Aged ≥18 Years — United States, 2015

(2016) James M. Dahlhamer et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Biomarkers in Nonalcoholic Fatty Liver Disease

(2016) Manuela G Neuman et al.   Canadian Journal of Gastroenterology and Hepatology

Cyanobacteria blooms and non-alcoholic liver disease: evidence from a county level ecological study in the United States

(2015) Feng Zhang et al.   Environmental Health

Rapid and sensitive analysis of microcystins using ionic liquid-based in situ dispersive liquid–liquid microextraction

(2015) Honglian Yu et al.   JOURNAL OF CHROMATOGRAPHY A

Structures and Activity of New Anabaenopeptins Produced by Baltic Sea Cyanobacteria

(2015) Lisa Spoof et al.   Marine Drugs

Repeated intranasal exposure to microcystin-LR affects lungs but not nasal epithelium in mice

(2015) Vinícius R. Oliveira et al.   TOXICON

Hepatic and intestine alterations in mice after prolonged exposure to low oral doses of Microcystin-LR

(2015) Daniela Sedan et al.   TOXICON

Human Illnesses and Animal Deaths Associated with Freshwater Harmful Algal Blooms—Kansas

(2015) Ingrid Trevino-Garrison et al.   Toxins

The Toledo Drinking Water Advisory: Suggested Application of the Water Safety Planning Approach

(2015) Savitri Jetoo et al.   Sustainability

Analysis of Trace Microcystins in Vegetables Using Solid-Phase Extraction Followed by High Performance Liquid Chromatography Triple-Quadrupole Mass Spectrometry

(2014) Yan-Wen Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Fate of Microcystins in the Environment and Challenges for Monitoring

(2014) Justine Schmidt et al.   Toxins

Biomarkers of prolonged exposure to microcystin-LR in mice

(2013) Daniela Sedan et al.   TOXICON

Cylindrospermopsin: Water-linked potential threat to human health in Europe

(2012) Barbara Poniedziałek et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Contamination by Microcystis and microcystins of blue–green algae food supplements (BGAS) on the italian market and possible risk for the exposed population

(2012) Susanna Vichi et al.   FOOD AND CHEMICAL TOXICOLOGY

Microcystin-LR: How it affects the cardio-respiratory responses to hypoxia in Nile tilapia, Oreochromis niloticus

(2011) Nathan Dias Martins et al.   CHEMOSPHERE

An Acute Case of Intoxication with Cyanobacteria and Cyanotoxins in Recreational Water in Salto Grande Dam, Argentina

(2011) Leda Giannuzzi et al.   Marine Drugs

Characterization of microcystin-LR removal process in the presence of probiotic bacteria

(2011) S.M.K. Nybom et al.   TOXICON

Molecular Mechanisms of Microcystin Toxicity in Animal Cells

(2010) Alexandre Campos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

On the Chemistry, Toxicology and Genetics of the Cyanobacterial Toxins, Microcystin, Nodularin, Saxitoxin and Cylindrospermopsin

(2010) Leanne Pearson et al.   Marine Drugs

The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: A comparison of primary human hepatocytes and OATP-transfected HEK293 cells

(2010) A. Fischer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Recreational exposure to microcystins during algal blooms in two California lakes

(2009) Lorraine C. Backer et al.   TOXICON

The state of U.S. freshwater harmful algal blooms assessments, policy and legislation

(2009) H. Kenneth Hudnell   TOXICON

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

The profound effects of microcystin on cardiac antioxidant enzymes, mitochondrial function and cardiac toxicity in rat

(2008) Tong Qiu et al.   TOXICOLOGY

Specific strains of probiotic bacteria are efficient in removal of several different cyanobacterial toxins from solution

(2008) Sonja M.K. Nybom et al.   TOXICON

In vivo DNA damage induced by the cyanotoxin microcystin-LR: Comparison of intra-peritoneal and oral administrations by use of the comet assay

(2007) Julien Gaudin et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS