CD40 Receptor Knockout Protects against Microcystin-LR (MC-LR) Prolongation and Exacerbation of Dextran Sulfate Sodium (DSS)-Induced Colitis

Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of Cd40 in Experimental Renal Ischemia

(2020) Shungang Zhang et al.   Journal of the American Heart Association

Exposure to the Harmful Algal Bloom (HAB) Toxin Microcystin-LR (MC-LR) Prolongs and Increases Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis

(2019) Robin C. Su et al.   Toxins

Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease

(2019) Apurva Lad et al.   Toxins

Hyperglycemia induces key genetic and phenotypic changes in human liver epithelial HepG2 cells which parallel the Leprdb/J mouse model of non-alcoholic fatty liver disease (NAFLD)

(2019) Robin C. Su et al.   PLoS One

Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice

(2019) Xiping Yi et al.   International Journal of Environmental Research and Public Health

Uptake and accumulation of Microcystin-LR based on exposure through drinking water: An animal model assessing the human health risk

(2018) Brett Greer et al.   Scientific Reports

Chemoprevention of inflammation-related colorectal cancer by silymarin-, acetyl-11-keto-beta-boswellic acid-, curcumin- and maltodextrin-enriched dietetic formulation in animal model

(2018) Bruna Girardi et al.   CARCINOGENESIS

Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na+/K+-ATPase Profibrotic Signaling Pathways

(2018) David Kennedy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of Microcystin-LR on Liver Function Varies by Dose and Sex in Mice

(2018) Igor Mrdjen et al.   Toxins

Targeted disruption of Cd40 in a genetically hypertensive rat model attenuates renal fibrosis and proteinuria, independent of blood pressure

(2017) Steven T. Haller et al.   KIDNEY INTERNATIONAL

Na/K-ATPase/src complex mediates regulation of CD40 in renal parenchyma

(2017) Jeffrey X Xie et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Microcystin-LR induced liver injury in mice and in primary human hepatocytes is caused by oncotic necrosis

(2017) Benjamin L. Woolbright et al.   TOXICON

Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice

(2017) Manish Kumar Jeengar et al.   Scientific Reports

Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease

(2017) Jeffrey X. Xie et al.   Scientific Reports

Prevalence of Inflammatory Bowel Disease Among Adults Aged ≥18 Years — United States, 2015

(2016) James M. Dahlhamer et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Hepatic and intestine alterations in mice after prolonged exposure to low oral doses of Microcystin-LR

(2015) Daniela Sedan et al.   TOXICON

A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice

(2014) Gisela M. Vaitaitis et al.   DIABETOLOGIA

Effect of CD40 and sCD40L on Renal Function and Survival in Patients With Renal Artery Stenosis

(2013) Steven T. Haller et al.   HYPERTENSION

Impaired NFAT and NFκB activation are involved in suppression of CD40 ligand expression by Δ9-tetrahydrocannabinol in human CD4+ T cells

(2013) Thitirat Ngaotepprutaram et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The CD40-CD40L Pathway Contributes to the Proinflammatory Function of Intestinal Epithelial Cells in Inflammatory Bowel Disease

(2010) Frauke Borcherding et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular Mechanisms of Microcystin Toxicity in Animal Cells

(2010) Alexandre Campos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular mechanism and function of CD40/CD40L engagement in the immune system

(2009) Raul Elgueta et al.   IMMUNOLOGICAL REVIEWS