Article
Biochemistry & Molecular Biology
Zhenzhen Pan, Kai Wang, Xiniao Wang, Zhirong Jia, Yuqi Yang, Yalei Duan, Lianzhan Huang, Zhuo-Xun Wu, Jian-ye Zhang, Xuansheng Ding
Summary: This study reveals a common molecular mechanism underlying EGFR-TKIs resistance in non-small cell lung cancer, involving cholesterol accumulation, EGFR/Src/Erk/SP1 axis-mediated ERR alpha re-expression and subsequent cell proliferation. Lowering cholesterol levels and downregulating ERR alpha can overcome resistance to gefitinib and osimertinib.
Article
Cell Biology
Naoya Hino, Kimiya Matsuda, Yuya Jikko, Gembu Maryu, Katsuya Sakai, Ryu Imamura, Shinya Tsukiji, Kazuhiro Aoki, Kenta Terai, Tsuyoshi Hirashima, Xavier Trepat, Michiyuki Matsuda
Summary: The extension of lamellipodia in leader cells causes sustained activation of ERK, resulting in the specification of these cells during collective cell migration. The increased sensitivity of cells at the free edge to HGF promotes lamellipodial extension, forming a positive feedback loop between cell extension and ERK activation.
DEVELOPMENTAL CELL
(2022)
Article
Oncology
Qi Lin, Zhen Chen, Zhao-Li Shen, Fei Xue, Jia-Jun Qin, Xi-Peng Kang, Zhong-Rong Chen, Zhong -Yuan Xia, Liang Gao, Xian-Zhen Chen
Summary: TRAF3IP3 is associated with poor prognosis in glioma patients and promotes tumor growth, migration, and invasion by activating the ERK signaling pathway. These findings suggest that TRAF3IP3 could serve as a potential biomarker for glioma prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ran Wang, Wei Huang, Kaimei Cai, Shihan Xiao, Wuming Zhang, Xianqin Hu, Jianping Guo, Linfeng Mao, Weijie Yuan, Yi Xu, Zihua Chen, Zhikang Chen, Chen Lai
Summary: Flotillin-1 (FLOT1) promotes gastric cancer progression and metastasis through interaction with BCAR1 via ERK signaling. FLOT1 regulates BCAR1 phosphorylation and translocation, and BCAR1 knockdown blocks FLOT1-induced gastric cancer cell proliferation, migration, and invasion. Moreover, the expression of FLOT1 and BCAR1 is closely related to poor prognosis in gastric cancer patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Yen-Yun Wang, Anupama Vadhan, Ping-Ho Chen, Yen-Lung Lee, Chih-Yeh Chao, Kuang-Hung Cheng, Yu-Chiuan Chang, Stephen Chu-Sung Hu, Shyng-Shiou F. Yuan
Summary: The study investigated the role of CD44 in lung cancer metastasis through clinical, in vitro, and in vivo studies, revealing that CD44 promotes migration and invasion abilities of lung cancer cells. Understanding and targeting CD44 may offer potential therapeutic strategies to decrease lung cancer metastasis.
Article
Oncology
Hina Mir, Neeraj Kapur, Dominique N. Gales, Praveen K. Sharma, Gabriela Oprea-Ilies, Anita T. Johnson, Rajesh Singh, Shailesh Singh
Summary: Breast cancer (BrCa) is the second leading cause of cancer-related deaths in American women, and its incidence is increasing. This study highlights the importance of the chemokine axis CXCR6/CXCL16 in promoting BrCa and suggests it as a potential therapeutic target for advanced-stage BrCa.
Article
Biochemistry & Molecular Biology
Jia-cheng Xu, Tian-yin Chen, Le-tai Liao, Tao Chen, Quan-lin Li, Jia-xin Xu, Jian-wei Hu, Ping-hong Zhou, Yi-qun Zhang
Summary: Our study revealed that high expression of NETO2 in ESCC patients was associated with tumor staging and lymph node metastasis, promoting ESCC progression through enhancing cell proliferation, suppressing apoptosis, and stimulating tumor growth. Additionally, NETO2 was found to play a crucial role in regulating migration, invasion, and epithelial-mesenchymal transition in ESCC cells. Mechanistically, NETO2 activated ERK, PI3k/AKT, and Nrf2 signaling pathways, with Nrf2 identified as a critical downstream mediator responsible for tumorigenesis. This suggests that NETO2 may serve as a potential therapeutic target or prognostic biomarker for ESCC patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yaqiong Yang, Yu Sun, Rong Hu, Jia Yan, Ziheng Wang, Wenlong Li, Hong Jiang
Summary: This study investigated the regulatory mechanism of epidermal growth factor receptor (EGFR) on microglial activation induced by morphine in BV-2 cells. The results showed that morphine treatment increased CD11b expression, EGFR phosphorylation, ERK1/2 activation, cell migration, and production of proinflammatory cytokines, which were inhibited by blocking the EGFR signaling pathway with AG1478. These findings suggest that the EGFR/ERK signaling pathway could be a novel pharmacological strategy to attenuate morphine tolerance by suppressing microglial activation.
Article
Horticulture
Han Wang, Xin Zhao, Ying Wang, Wen-Fang Li, Meng-Fei Li, Zong-Huan Ma, Mujitaba Dawuda, Cun-Wu Zuo, Ming-Yu Chu, Juan Mao, Bai-Hong Chen
Summary: Adding exogenous carbon under high CO2 concentration significantly promotes the growth of 'Pinot Noir' grape plants, as evidenced by increased leaf area, plant height, and shoot fresh weight. This effect may be related to the regulation of ethylene biosynthesis and signaling pathways.
SCIENTIA HORTICULTURAE
(2022)
Article
Plant Sciences
Yaqi Kang, Jing Lin, Long Wang, Xin Shen, Jingyan Li, Anguo Wu, Liang Yue, Liuping Wei, Yun Ye, Jing Yang, Jianming Wu
Summary: This study identifies Hirsutine as a potential treatment option for thrombocytopenia, as it promotes megakaryocytic differentiation and maturation through the MEK/ERK/FOG1/TAL1 signaling pathway.
Article
Cell Biology
Hanlin Ma, Fang Han, Xiaohui Yan, Gonghua Qi, Yingwei Li, Rongrong Li, Shi Yan, Cunzhong Yuan, Kun Song, Beihua Kong
Summary: Cervical cancer is the fourth most common cancer in women globally, and the overexpression of PBK in cervical cancer tissues promotes proliferation, metastasis, and cisplatin resistance of cancer cells through the ERK/c-Myc signaling pathway. Inhibition of PBK with OTS514 shows promising results in suppressing tumor growth and enhancing chemosensitivity. Further studies on PBK as a molecular target for cervical cancer treatment are warranted.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hana Lee, Won-Jin Kim, Hyeon-Gu Kang, Jun-Ho Jang, Il Ju Choi, Kyung-Hee Chun, Seok-Jun Kim
Summary: The study found that LAMB1 is upregulated in gastric cancer and contributes to cell growth and motility. The expression level of LAMB1 is closely associated with the prognosis of patients with gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Longping Huang, Si Chen, Haijun Fan, Dawei Ji, Chuanping Chen, Weiwei Sheng
Summary: GINS2, as a newly discovered oncogene, is overexpressed in pancreatic cancer and positively associated with tumor progression. Its overexpression promotes epithelial-mesenchymal transition (EMT) through activation of ERK/MAPK signaling pathway, contributing to poor prognosis in PC patients.
CANCER GENE THERAPY
(2021)
Article
Cell Biology
Anfei Liu, Yunting Li, Sitong Lu, Chunqing Cai, Fei Zou, Xiaojing Meng
Summary: Lung metastasis is a major cause of breast cancer-related death. Tumor microenvironment and secreted factors, such as STC1, play important roles in promoting the metastasis. STC1 enhances cancer cell invasiveness, promotes angiogenesis and lung fibroblast activation in the metastatic microenvironment. Mechanistically, STC1 mediates its effects through the upregulation of S100A4 via EGFR and ERK signaling. Knockdown of S100A4 diminishes STC1-induced lung metastasis. Additionally, JNK signaling pathway activates STC1 expression in breast cancer cells with lung-tropism.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Nabila Founounou, Reza Farhadifar, Giovanna M. Collu, Ursula Weber, Michael J. Shelley, Marek Mlodzik
Summary: The study highlights the critical role of the Nemo molecule in regulating the transition from solid to viscoelastic tissues in the process of cell migration, emphasizing the importance of junctional remodeling regulation for tissue fluidity.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Mana Furuoka, Kei-Ichi Ozaki, Daichi Sadatomi, Sayaka Mamiya, Tomo Yonezawa, Susumu Tanimura, Kohsuke Takeda
JOURNAL OF CELLULAR PHYSIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Daichi Sadatomi, Kazutaka Nakashioya, Sayaka Mamiya, Shino Honda, Yuka Kameyama, Yasuo Yamamura, Susumu Tanimura, Kohsuke Takeda
JOURNAL OF BIOCHEMISTRY
(2017)
Review
Biochemistry & Molecular Biology
Susumu Tanimura, Kohsuke Takeda
JOURNAL OF BIOCHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Apirat Chaikuad, Panagis Filippakopoulos, Sean R. Marcsisin, Sarah Picaud, Martin Schroeder, Shiori Sekine, Hidenori Ichijo, John R. Engen, Kohsuke Takeda, Stefan Knapp
Article
Biochemistry & Molecular Biology
Ran Cheng, Kohsuke Takeda, Isao Naguro, Tomohisa Hatta, Shun-ichiro Iemura, Tohru Natsume, Hidenori Ichijo, Kazuki Hattori
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2018)
Article
Biochemistry & Molecular Biology
Ayane Yamaguchi, Hayate Ishikawa, Mana Furuoka, Masashi Yokozeki, Noriyuki Matsuda, Susumu Tanimura, Kohsuke Takeda
JOURNAL OF BIOCHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Nana Nakada-Motokawa, Taiga Miyazaki, Satoshi Mizuta, Yoshimasa Tanaka, Tatsuro Hirayama, Takahiro Takazono, Tomomi Saijo, Kazuko Yamamoto, Yoshifumi Imamura, Koichi Izumikawa, Katsunori Yanagihara, Koichi Makimura, Kohsuke Takeda, Shigeru Kohno, Hiroshi Mukae
Article
Cell Biology
Shota Nakamura, Ritsuko Masuyama, Kosuke Sakai, Karin Fukuda, Kohsuke Takeda, Susumu Tanimura
Article
Oncology
Makoto Fujimoto, Miki Kamiyama, Kosuke Fuse, Hiroki Ryuno, Takeru Odawara, Natsuki Furukawa, Yasuhiro Yoshimatsu, Tetsuro Watabe, Michaela Prchal-Murphy, Veronika Sexl, Hideaki Tahara, Yoshihiro Hayakawa, Takehiro Sato, Kohsuke Takeda, Isao Naguro, Hidenori Ichijo
Summary: The study demonstrates that ASK1 deficiency promotes NK cell-mediated intravascular tumor cell clearance and upregulates immune response-related genes, including IFN gamma, to enhance the anti-metastatic phenotypes. NK cells are required for these anti-metastatic phenotypes.
Article
Biochemistry & Molecular Biology
Tianli Zhang, Hiroyasu Tsutsuki, Waliul Islam, Katsuhiko Ono, Kohsuke Takeda, Takaaki Akaike, Tomohiro Sawa
Summary: ATP exposure leads to a sharp decrease in glutathione (GSH) levels in macrophages, triggering NLRP3 inflammasome activation. Exogenous addition of GSH or GSSG can inhibit GSH efflux and attenuate NLRP3 inflammasome activation. This finding may contribute to the development of novel therapeutic strategies for NLRP3 inflammasome-associated disorders.
Article
Biochemistry & Molecular Biology
Taiki Baba, Susumu Tanimura, Ayane Yamaguchi, Koichiro Horikawa, Masashi Yokozeki, Saki Hachiya, Shun-Ichiro Iemura, Tohru Natsume, Noriyuki Matsuda, Kohsuke Takeda
Summary: PGAM5 is a protein phosphatase located in the inner mitochondrial membrane, which is cleaved and released into the nucleus upon mitochondrial dysfunction. It interacts with nuclear protein SRm160, dephosphorylates it, and regulates phosphorylation of other SR proteins during mitophagy, potentially coordinating cellular responses to mitochondrial stress at the post-transcriptional and pretranslational levels.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Hidetaka Hiyama, Naoya Arichika, Minoru Okada, Noriyuki Koyama, Tomonori Tahara, Junpei Haruta
Summary: Difamilast, a novel selective phosphodiesterase 4 (PDE4) inhibitor, demonstrated significant efficacy without adverse reactions in patients with atopic dermatitis. Nonclinical studies showed that Difamilast selectively inhibited PDE4 activity, improved skin inflammation, and had a favorable pharmacokinetic profile.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Miki Kamiyama, Toshiaki Shirai, Shogo Tamura, Katsue Suzuki-Inoue, Shogo Ehata, Kei Takahashi, Kohei Miyazono, Yoshihiro Hayakawa, Takehiro Sato, Kohsuke Takeda, Isao Naguro, Hidenori Ichijo
CELL DEATH AND DIFFERENTIATION
(2017)
Article
Oncology
Shino Honda, Daichi Sadatomi, Yasuo Yamamura, Kazutaka Nakashioya, Susumu Tanimura, Kohsuke Takeda