ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation

Astrocyte glutathione maintains endothelial barrier stability

(2020) Sheng-Fu Huang et al.   Redox Biology

Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome

(2020) Wenbiao Wang et al.   BMC BIOLOGY

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gasdermins and their role in immunity and inflammation

(2019) Pontus Orning et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emerging Activators and Regulators of Inflammasomes and Pyroptosis

(2019) Yansong Xue et al.   TRENDS IN IMMUNOLOGY

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

(2019) Mark M. Hughes et al.   Cell Reports

Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes

(2018) Tao Gong et al.   TRENDS IN IMMUNOLOGY

NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury

(2017) Merry W. Ma et al.   Oxidative Medicine and Cellular Longevity

Positive Regulation of Interleukin-1β Bioactivity by Physiological ROS-Mediated Cysteine S-Glutathionylation

(2017) Xue Zhang et al.   Cell Reports

Protein S-Glutathionylation Mediates Macrophage Responses to Metabolic Cues from the Extracellular Environment

(2016) Sarah L. Ullevig et al.   ANTIOXIDANTS & REDOX SIGNALING

Vitamin B6 Prevents IL-1β Protein Production by Inhibiting NLRP3 Inflammasome Activation

(2016) Peipei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine

(2015) L Baron et al.   Cell Death & Disease

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

(2015) Annette Ives et al.   Nature Communications

Antioxidant responses and cellular adjustments to oxidative stress

(2015) Cristina Espinosa-Diez et al.   Redox Biology

A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1  Processing in Human Monocytes

(2014) J. Hewinson et al.   JOURNAL OF IMMUNOLOGY

Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation

(2014) Joyce K Thompson et al.   Particle and Fibre Toxicology

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

(2014) T. Ida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein

(2014) Jungwon Hwang et al.   Nature Communications

Glutathione depletion in survival and apoptotic pathways

(2014) Milena De Nicola et al.   Frontiers in Pharmacology

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

TRPM2 links oxidative stress to NLRP3 inflammasome activation

(2013) Zhenyu Zhong et al.   Nature Communications

Glutathione Efflux and Cell Death

(2012) Rodrigo Franco et al.   ANTIOXIDANTS & REDOX SIGNALING

The participation of plasma membrane hemichannels to purinergic signaling

(2012) Alberto Baroja-Mazo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage

(2008) Takuya Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE