The Symmetry of Neural Stem Cell and Progenitor Divisions in the Vertebrate Brain

Centrosome maturation – in tune with the cell cycle

(2022) Jose Blanco-Ameijeiras et al.   JOURNAL OF CELL SCIENCE

The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors

(2021) Daniel J. Merk et al.   DEVELOPMENTAL NEUROSCIENCE

Neuronal Delamination and Outer Radial Glia Generation in Neocortical Development

(2021) Ayano Kawaguchi   Frontiers in Cell and Developmental Biology

An early cell shape transition drives evolutionary expansion of the human forebrain

(2021) Silvia Benito-Kwiecinski et al.   CELL

Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex

(2021) Fabio Da Silva et al.   EMBO JOURNAL

Human intermediate progenitor diversity during cortical development

(2021) Mark-Phillip Pebworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus

(2021) Bhavana Gupta et al.   Cell Reports

Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division

(2021) Xiang Zhao et al.   Science Advances

Lis1 mutation prevents basal radial glia-like cell production in the mouse

(2021) Maxime Penisson et al.   HUMAN MOLECULAR GENETICS

Primary Cilia and Centrosomes in Neocortex Development

(2021) Michaela Wilsch-Bräuninger et al.   Frontiers in Neuroscience

Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini

(2020) Susana I. Ramos et al.   DEVELOPMENTAL CELL

Single-cell biology: beyond the sum of its parts

(2020) Alexander F. Schier   NATURE METHODS

Adherens Junctions: Guardians of Cortical Development

(2020) Lenin Veeraval et al.   Frontiers in Cell and Developmental Biology

Centrosomes: The good and the bad for brain development

(2020) Véronique Marthiens et al.   BIOLOGY OF THE CELL

Centrosome anchoring regulates progenitor properties and cortical formation

(2020) Wei Shao et al.   NATURE

Cytokinesis and postabscission midbody remnants are regulated during mammalian brain development

(2020) Katrina C. McNeely et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lineage hierarchies and stochasticity ensure the long-term maintenance of adult neural stem cells

(2020) Emmanuel Than-Trong et al.   Science Advances

Principles and mechanisms of asymmetric cell division

(2020) Bharath Sunchu et al.   DEVELOPMENT

FGF2 modulates simultaneously the mode, the rate of division and the growth fraction in cultures of radial glia

(2020) Mario Ledesma-Terrón et al.   DEVELOPMENT

Stochasticity and determinism in cell fate decisions

(2020) Christoph Zechner et al.   DEVELOPMENT

Conserved and Divergent Features of Adult Neurogenesis in Zebrafish

(2020) Miriam Labusch et al.   Frontiers in Cell and Developmental Biology

Basal Progenitor Morphology and Neocortex Evolution

(2020) Nereo Kalebic et al.   TRENDS IN NEUROSCIENCES

mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex

(2020) Madeline G Andrews et al.   eLife

Next-Generation Lineage Tracing and Fate Mapping to Interrogate Development

(2020) Sadie VanHorn et al.   DEVELOPMENTAL CELL

Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging

(2020) Sara Bottes et al.   NATURE NEUROSCIENCE

Fate restrictions in embryonic neural progenitors

(2020) Evelyne Fischer et al.   CURRENT OPINION IN NEUROBIOLOGY

One progenitor to generate them all: new evidence for multi-fated neural progenitors

(2020) Gonzalo Ortiz-Álvarez et al.   CURRENT OPINION IN NEUROBIOLOGY

How the centriole builds its cilium: of mothers, daughters, and the acquisition of appendages

(2020) Dhivya Kumar et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Centrosomes in asymmetric cell division

(2020) Cayetano Gonzalez   CURRENT OPINION IN STRUCTURAL BIOLOGY

Deconstructing cortical folding: genetic, cellular and mechanical determinants

(2019) Cristina Llinares-Benadero et al.   NATURE REVIEWS NEUROSCIENCE

The centrosome protein AKNA regulates neurogenesis via microtubule organization

(2019) Germán Camargo Ortega et al.   NATURE

Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain

(2019) Kirsten Obernier et al.   DEVELOPMENT

Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology

(2019) Nereo Kalebic et al.   Cell Stem Cell

A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

(2019) Daniel A. Berg et al.   CELL

YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex

(2019) Milos Kostic et al.   Cell Reports

Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development

(2019) T. Kawaue et al.   Nature Communications

The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation

(2019) Eric Peterman et al.   Nature Communications

Asymmetric Centromeres Differentially Coordinate with Mitotic Machinery to Ensure Biased Sister Chromatid Segregation in Germline Stem Cells

(2019) Rajesh Ranjan et al.   Cell Stem Cell

Differences in Mitotic Spindle Architecture in Mammalian Neural Stem Cells Influence Mitotic Accuracy during Brain Development

(2019) Diana Vargas-Hurtado et al.   CURRENT BIOLOGY

Genes and Mechanisms Involved in the Generation and Amplification of Basal Radial Glial Cells

(2019) Maxime Penisson et al.   Frontiers in Cellular Neuroscience

A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture

(2019) Alfredo Llorca et al.   eLife

Where does asymmetry come from? Illustrating principles of polarity and asymmetry establishment in Drosophila neuroblasts

(2019) Nicolas Loyer et al.   CURRENT OPINION IN CELL BIOLOGY

Endfoot regeneration restricts radial glial state and prevents translocation into the outer subventricular zone in early mammalian brain development

(2019) Ikumi Fujita et al.   NATURE CELL BIOLOGY

Asymmetric Histone Inheritance in Asymmetrically Dividing Stem Cells

(2019) Matthew Wooten et al.   TRENDS IN GENETICS

Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex

(2019) Raphael M Bendriem et al.   eLife

Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels

(2018) Adrián Cárdenas et al.   CELL

Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation

(2018) Kirsten Obernier et al.   Cell Stem Cell

Centrosome Inheritance Does Not Regulate Cell Fate in Granule Neuron Progenitors of the Developing Cerebellum

(2018) Anindo Chatterjee et al.   CEREBELLUM

PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia

(2018) Wenying Angela Liu et al.   GENES & DEVELOPMENT

Cortical progenitor biology: key features mediating proliferation versus differentiation

(2018) Ana Uzquiano et al.   JOURNAL OF NEUROCHEMISTRY

Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7

(2018) Stefania Tavano et al.   NEURON

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

(2018) Onur Basak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live imaging of neurogenesis in the adult mouse hippocampus

(2018) Gregor-Alexander Pilz et al.   SCIENCE

The Evolution of Variability and Robustness in Neural Development

(2018) P. Robin Hiesinger et al.   TRENDS IN NEUROSCIENCES

Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination

(2018) Chooyoung Baek et al.   PLOS BIOLOGY

Emerging mechanisms of asymmetric stem cell division

(2018) Zsolt G. Venkei et al.   JOURNAL OF CELL BIOLOGY

Dynamic control of neural stem cells by bHLH factors

(2018) Ryoichiro Kageyama et al.   NEUROSCIENCE RESEARCH

A centrosomal view of CNS growth

(2018) Murielle Saade et al.   DEVELOPMENT

The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen

(2018) A. Denise R. Garcia et al.   JOURNAL OF NEUROSCIENCE

Increasing Neural Stem Cell Division Asymmetry and Quiescence Are Predicted to Contribute to the Age-Related Decline in Neurogenesis

(2018) Lisa Bast et al.   Cell Reports

Moving messages in the developing brain-emerging roles for mRNA transport and local translation in neural stem cells

(2017) Louis-Jan Pilaz et al.   FEBS LETTERS

Cerebral cortex development: an outside-in perspective

(2017) Gulistan Agirman et al.   FEBS LETTERS

Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division

(2017) Murielle Saade et al.   NATURE CELL BIOLOGY

Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding

(2017) Sven Falk et al.   NEURON

Differential Routing of Mindbomb1 via Centriolar Satellites Regulates Asymmetric Divisions of Neural Progenitors

(2017) Samuel Tozer et al.   NEURON

Dynamic behaviour of human neuroepithelial cells in the developing forebrain

(2017) Lakshmi Subramanian et al.   Nature Communications

Spatial distribution and characterization of non-apical progenitors in the zebrafish embryo central nervous system

(2017) Rebecca McIntosh et al.   Open Biology

Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination

(2017) Ioannis Kasioulis et al.   eLife

Dynamic mRNA Transport and Local Translation in Radial Glial Progenitors of the Developing Brain

(2016) Louis-Jan Pilaz et al.   CURRENT BIOLOGY

Regulation of mitotic spindle orientation: an integrated view

(2016) Florencia di Pietro et al.   EMBO REPORTS

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate

(2016) Divya Jayaraman et al.   NEURON

The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice

(2016) Xiang-Chun Ju et al.   eLife

Embryonic Origin of Postnatal Neural Stem Cells

(2015) Luis C. Fuentealba et al.   CELL

Molecular Identity of Human Outer Radial Glia during Cortical Development

(2015) Alex A. Pollen et al.   CELL

Midbody: from cellular junk to regulator of cell polarity and cell fate

(2015) Lai Kuan Dionne et al.   CURRENT OPINION IN CELL BIOLOGY

Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function

(2015) A. Paolini et al.   DEVELOPMENT

Notch Activity Modulates the Responsiveness of Neural Progenitors to Sonic Hedgehog Signaling

(2015) Jennifer H. Kong et al.   DEVELOPMENTAL CELL

Unsupervised lineage-based characterization of primate precursors reveals high proliferative and morphological diversity in the OSVZ

(2015) Michael Pfeiffer et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Polarized endosome dynamics by spindle asymmetry during asymmetric cell division

(2015) Emmanuel Derivery et al.   NATURE

Directional Notch trafficking in Sara endosomes during asymmetric cell division in the spinal cord

(2015) Sabine Kressmann et al.   NATURE CELL BIOLOGY

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

(2015) Shohei Furutachi et al.   NATURE NEUROSCIENCE

A mechanism for the segregation of age in mammalian neural stem cells

(2015) D. L. Moore et al.   SCIENCE

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

(2015) P. Katajisto et al.   SCIENCE

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion

(2015) M. Florio et al.   SCIENCE

Polarity transitions during neurogenesis and germinal zone exit in the developing central nervous system

(2015) Shalini Singh et al.   Frontiers in Cellular Neuroscience

N-cadherin-based adherens junction regulates the maintenance, proliferation, and differentiation of neural progenitor cells during development

(2015) Yasunori Miyamoto et al.   Cell Adhesion & Migration

Centriole Amplification in Zebrafish Affects Proliferation and Survival but Not Differentiation of Neural Progenitor Cells

(2015) Edo Dzafic et al.   Cell Reports

The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex

(2014) Elena Taverna et al.   Annual Review of Cell and Developmental Biology

Deterministic Progenitor Behavior and Unitary Production of Neurons in the Neocortex

(2014) Peng Gao et al.   CELL

Sara endosomes and the asymmetric division of intestinal stem cells

(2014) C. Montagne et al.   DEVELOPMENT

Diverse Behaviors of Outer Radial Glia in Developing Ferret and Human Cortex

(2014) C. C. Gertz et al.   JOURNAL OF NEUROSCIENCE

Cortical neurogenesis in the absence of centrioles

(2014) Ryan Insolera et al.   NATURE NEUROSCIENCE

Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number

(2014) Wen F. Hu et al.   NEURON

Apical Abscission Alters Cell Polarity and Dismantles the Primary Cilium During Neurogenesis

(2014) R. M. Das et al.   SCIENCE

Control of Outer Radial Glial Stem Cell Mitosis in the Human Brain

(2014) Bridget E.L. Ostrem et al.   Cell Reports

Mitotic Spindle Asymmetry: A Wnt/PCP-Regulated Mechanism Generating Asymmetrical Division in Cortical Precursors

(2014) Delphine Delaunay et al.   Cell Reports

Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division

(2014) Felipe Mora-Bermúdez et al.   eLife

Asymmetric Inheritance of Centrosome-Associated Primary Cilium Membrane Directs Ciliogenesis after Cell Division

(2013) Judith T.M.L. Paridaen et al.   CELL

Dynamic Interactions between Intermediate Neurogenic Progenitors and Radial Glia in Embryonic Mouse Neocortex: Potential Role in Dll1-Notch Signaling

(2013) B. R. Nelson et al.   JOURNAL OF NEUROSCIENCE

Centrosome amplification causes microcephaly

(2013) Véronique Marthiens et al.   NATURE CELL BIOLOGY

Precursor Diversity and Complexity of Lineage Relationships in the Outer Subventricular Zone of the Primate

(2013) Marion Betizeau et al.   NEURON

A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro

(2013) S. J. Habib et al.   SCIENCE

Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex

(2013) Bridget E. LaMonica et al.   Nature Communications

Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis

(2013) Daichi Kawaguchi et al.   Nature Communications

Sonic Hedgehog Signaling Switches the Mode of Division in the Developing Nervous System

(2013) Murielle Saade et al.   Cell Reports

Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis

(2012) B. S. Clark et al.   DEVELOPMENT

Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates

(2012) Yuji Tsunekawa et al.   EMBO JOURNAL

Mitotic spindle orientation can direct cell fate and bias Notch activity in chick neural tube

(2012) Raman M. Das et al.   EMBO REPORTS

Intralineage Directional Notch Signaling Regulates Self-Renewal and Differentiation of Asymmetrically Dividing Radial Glia

(2012) Zhiqiang Dong et al.   NEURON

How Variable Clones Build an Invariant Retina

(2012) Jie He et al.   NEURON

Comparative Analysis of the Subventricular Zone in Rat, Ferret and Macaque: Evidence for an Outer Subventricular Zone in Rodents

(2012) Verónica Martínez-Cerdeño et al.   PLoS One

A novel reporter of notch signalling indicates regulated and random notch activation during vertebrate neurogenesis

(2011) Filipe Vilas-Boas et al.   BMC BIOLOGY

Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination

(2011) M. Wilsch-Brauninger et al.   DEVELOPMENT

A lateral belt of cortical LGN and NuMA guides mitotic spindle movements and planar division in neuroepithelial cells

(2011) Elise Peyre et al.   JOURNAL OF CELL BIOLOGY

Oblique Radial Glial Divisions in the Developing Mouse Neocortex Induce Self-Renewing Progenitors outside the Germinal Zone That Resemble Primate Outer Subventricular Zone Progenitors

(2011) A. Shitamukai et al.   JOURNAL OF NEUROSCIENCE

Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity

(2011) Tse-Chun Kuo et al.   NATURE CELL BIOLOGY

A new subtype of progenitor cell in the mouse embryonic neocortex

(2011) Xiaoqun Wang et al.   NATURE NEUROSCIENCE

Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate decisions

(2010) F. L. A. F. Gomes et al.   DEVELOPMENT

Neurons derive from the more apical daughter in asymmetric divisions in the zebrafish neural tube

(2010) Paula Alexandre et al.   NATURE NEUROSCIENCE

Centriole Age Underlies Asynchronous Primary Cilium Growth in Mammalian Cells

(2009) Charles T. Anderson et al.   CURRENT BIOLOGY

Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division

(2009) F. Coumailleau et al.   NATURE

Asymmetric centrosome inheritance maintains neural progenitors in the neocortex

(2009) Xiaoqun Wang et al.   NATURE

Mammalian Par3 Regulates Progenitor Cell Asymmetric Division via Notch Signaling in the Developing Neocortex

(2009) Ronald S. Bultje et al.   NEURON

Fgf10 Regulates Transition Period of Cortical Stem Cell Differentiation to Radial Glia Controlling Generation of Neurons and Basal Progenitors

(2009) Setsuko Sahara et al.   NEURON

Cytokinesis of neuroepithelial cells can divide their basal process before anaphase

(2008) Yoichi Kosodo et al.   EMBO JOURNAL