Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer

Androgen receptor activity in T cells limits checkpoint blockade efficacy

(2022) Xiangnan Guan et al.   NATURE

Prospective analyses of testosterone and sex hormone‐binding globulin with the risk of 19 types of cancer in men and postmenopausal women in UK Biobank

(2021) Eleanor L. Watts et al.   INTERNATIONAL JOURNAL OF CANCER

IRIS3: integrated cell-type-specific regulon inference server from single-cell RNA-Seq

(2020) Anjun Ma et al.   NUCLEIC ACIDS RESEARCH

Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer

(2020) David Y. Oh et al.   CELL

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(2020) Patrick L. Collins et al.   Nature Communications

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

(2019) Sema Kurtulus et al.   IMMUNITY

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

(2019) Deepali V. Sawant et al.   NATURE IMMUNOLOGY

TOX is a critical regulator of tumour-specific T cell differentiation

(2019) Andrew C. Scott et al.   NATURE

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

Clonal replacement of tumor-specific T cells following PD-1 blockade

(2019) Kathryn E. Yost et al.   NATURE MEDICINE

PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity

(2019) Martin W. LaFleur et al.   NATURE IMMUNOLOGY

TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

(2019) Zeyu Chen et al.   IMMUNITY

ImmGen report: sexual dimorphism in the immune system transcriptome

(2019) Shani Talia Gal-Oz et al.   Nature Communications

A GPR174–CCL21 module imparts sexual dimorphism to humoral immunity

(2019) Ruozhu Zhao et al.   NATURE

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

(2019) Caroline S. Jansen et al.   NATURE

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

(2018) Kelly Street et al.   BMC GENOMICS

T Cell Dysfunction in Cancer

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Cancer immunotherapy efficacy and patients' sex: a systematic review and meta-analysis

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Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

(2018) Xinyi Guo et al.   NATURE MEDICINE

A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer

(2018) Damiano Fantini et al.   ONCOGENE

X chromosome protects against bladder cancer in females via aKDM6A-dependent epigenetic mechanism

(2018) Satoshi Kaneko et al.   Science Advances

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

High-dimensional single cell analysis identifies stem-like cytotoxic CD8+T cells infiltrating human tumors

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Sex as a predictor of response to cancer immunotherapy

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Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy

(2018) Thibault Le Bourgeois et al.   Frontiers in Oncology

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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

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(2017) Xiaojie Qiu et al.   NATURE METHODS

HOCOMOCO: towards a complete collection of transcription factor binding models for human and mouse via large-scale ChIP-Seq analysis

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Finasteride Reduces Risk of Bladder Cancer in a Large Prospective Screening Study

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T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

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Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

(2016) Ran He et al.   NATURE

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

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Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias

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FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data

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Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer

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Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation

(2014) Haydn T. Kissick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

(2013) Taku Okazaki et al.   NATURE IMMUNOLOGY

Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer

(2012) Zhaoyu Li et al.   CELL

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(2012) Ben Langmead et al.   NATURE METHODS

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Cytogenetic characterization of the murine bladder cancer model MB49 and the derived invasive line MB49-I

(2012) Victoria T. Fabris et al.   Cancer Genetics

DREME: motif discovery in transcription factor ChIP-seq data

(2011) Timothy L. Bailey   BIOINFORMATICS

Tissue-specific mutagenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine as the basis for urothelial carcinogenesis

(2011) Zhiming He et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

The Shedding of CD62L (L-Selectin) Regulates the Acquisition of Lytic Activity in Human Tumor Reactive T Lymphocytes

(2011) Shicheng Yang et al.   PLoS One

T-cell exhaustion: characteristics, causes and conversion

(2010) John S. Yi et al.   IMMUNOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Androgen ablation augments human HLA2.1-restricted T cell responses to PSA self-antigen in transgenic mice

(2010) Mohamed S. Arredouani et al.   PROSTATE

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

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Mouse Models for Evaluating Sex Chromosome Effects that Cause Sex Differences in Non-Gonadal Tissues

(2009) Arthur P. Arnold   JOURNAL OF NEUROENDOCRINOLOGY

Selective expansion of a subset of exhausted CD8 T cells by  PD-L1 blockade

(2008) S. D. Blackburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2008) Yong Zhang et al.   GENOME BIOLOGY