X chromosome protects against bladder cancer in females via aKDM6A-dependent epigenetic mechanism

Landscape of X chromosome inactivation across human tissues

(2017) Taru Tukiainen et al.   NATURE

Census and evaluation of p53 target genes

(2017) M Fischer   ONCOGENE

Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2

(2017) Lian Dee Ler et al.   Science Translational Medicine

Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma

(2016) Jakob Hedegaard et al.   CANCER CELL

UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia

(2016) Aissa Benyoucef et al.   GENES & DEVELOPMENT

Risk of solid tumors and hematological malignancy in persons with Turner and Klinefelter syndromes: A national cohort study

(2016) Jianguang Ji et al.   INTERNATIONAL JOURNAL OF CANCER

UTX demethylase activity is required for satellite cell–mediated muscle regeneration

(2016) Hervé Faralli et al.   JOURNAL OF CLINICAL INVESTIGATION

A general theory of sexual differentiation

(2016) Arthur P. Arnold   JOURNAL OF NEUROSCIENCE RESEARCH

Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias

(2016) Andrew Dunford et al.   NATURE GENETICS

Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response

(2016) M L Nickerson et al.   ONCOGENE

A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues

(2016) Paul S. Burgoyne et al.   Biology of Sex Differences

CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer

(2015) Ming T. Cheah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Escape from X Inactivation Varies in Mouse Tissues

(2015) Joel B. Berletch et al.   PLoS Genetics

Derivation of consensus inactivation status for X-linked genes from genome-wide studies

(2015) Bradley P. Balaton et al.   Biology of Sex Differences

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

(2014) Joni Van der Meulen et al.   BLOOD

UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells

(2014) Jae-Hwan Kim et al.   CANCER RESEARCH

Conceptual frameworks and mouse models for studying sex differences in physiology and disease: Why compensation changes the game

(2014) Arthur P. Arnold   EXPERIMENTAL NEUROLOGY

Comprehensive molecular characterization of urothelial bladder carcinoma

(2014)   NATURE

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

(2014) Panagiotis Ntziachristos et al.   NATURE

Bladder cancers arise from distinct urothelial sub-populations

(2014) Jason Van Batavia et al.   NATURE CELL BIOLOGY

Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma

(2014) Kunyoo Shin et al.   NATURE CELL BIOLOGY

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

(2014) Lars A Forsberg et al.   NATURE GENETICS

Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones

(2014) James M. Amos-Landgraf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Tumorigenesis and Mortality from Bladder Cancer in Mice Lacking Urothelial Androgen Receptor

(2013) Jong-Wei Hsu et al.   AMERICAN JOURNAL OF PATHOLOGY

Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells

(2013) Kadir C. Akdemir et al.   NUCLEIC ACIDS RESEARCH

Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer

(2012) Zhaoyu Li et al.   CELL

Enigmatic sex disparities in cancer incidence

(2012) Gustaf Edgren et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

(2012) C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-specific mutagenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine as the basis for urothelial carcinogenesis

(2011) Zhiming He et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

(2011) Yaoting Gui et al.   NATURE GENETICS

The histone demethylase UTX enables RB-dependent cell fate control

(2010) J. K. Wang et al.   GENES & DEVELOPMENT

Cancer incidence in women with Turner syndrome in Great Britain: a national cohort study

(2008) Minouk J Schoemaker et al.   LANCET ONCOLOGY