The innate immune response, microenvironment proteinases, and the COVID-19 pandemic: pathophysiologic mechanisms and emerging therapeutic targets
出版年份 2022 全文链接
标题
The innate immune response, microenvironment proteinases, and the COVID-19 pandemic: pathophysiologic mechanisms and emerging therapeutic targets
作者
关键词
COVID-19, fibrosis, innate immune response, proteases, SARS-CoV-2
出版物
Kidney International Supplements
Volume 12, Issue 1, Pages 48-62
出版商
Elsevier BV
发表日期
2022-03-18
DOI
10.1016/j.kisu.2021.12.001
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Clinical perspective—evolving evidence of mineralocorticoid receptor antagonists in patients with chronic kidney disease and type 2 diabetes
- (2022) Peter Rossing Kidney International Supplements
- Aldosterone and mineralocorticoid receptor signaling as determinants of cardiovascular and renal injury: an extraordinary paradigm shift
- (2022) Murray Epstein Kidney International Supplements
- The role of mineralocorticoid receptor activation in kidney inflammation and fibrosis
- (2022) James M. Luther et al. Kidney International Supplements
- The renin–angiotensin system biomolecular cascade: a 2022 update of newer insights and concepts
- (2022) Carlos M. Ferrario et al. Kidney International Supplements
- Epidemiology of chronic kidney disease: an update 2022
- (2022) Csaba P. Kovesdy Kidney International Supplements
- Mineralocorticoid receptor activation and antagonism in cardiovascular disease: cellular and molecular mechanisms
- (2022) Johann Bauersachs et al. Kidney International Supplements
- Nonepithelial mineralocorticoid receptor activation as a determinant of kidney disease
- (2022) Toshifumi Nakamura et al. Kidney International Supplements
- The innate immune response, microenvironment proteinases, and the COVID-19 pandemic: pathophysiologic mechanisms and emerging therapeutic targets
- (2022) Morley D. Hollenberg et al. Kidney International Supplements
- Considerations for the future: current and future treatment paradigms with mineralocorticoid receptor antagonists—unmet needs and underserved patient cohorts
- (2022) Murray Epstein Kidney International Supplements
- Kinins and Chymase: The Forgotten Components of the Renin angiotensin system and their implications in COVID-19 Disease
- (2021) Zaid Abassi et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- The interplay between neutrophils, complement, and microthrombi in COVID-19
- (2021) Yu Zuo et al. BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
- Microthrombi As A Major Cause of Cardiac Injury in COVID-19: A Pathologic Study
- (2021) Dario Pellegrini et al. CIRCULATION
- Pulmonary function and radiological features four months after COVID-19: first results from the national prospective observational Swiss COVID-19 lung study
- (2021) Sabina A. Guler et al. EUROPEAN RESPIRATORY JOURNAL
- The Mineralocorticoid Receptor in Salt-Sensitive Hypertension and Renal Injury
- (2021) Nobuhiro Ayuzawa et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- A new storm on the horizon in COVID-19: Bradykinin-induced vascular complications
- (2021) Cameron G. McCarthy et al. VASCULAR PHARMACOLOGY
- Continuation versus discontinuation of renin–angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial
- (2021) Jordana B Cohen et al. Lancet Respiratory Medicine
- COVID-19 and the human innate immune system
- (2021) Joachim L. Schultze et al. CELL
- A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids
- (2021) Jan Wysocki et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
- (2021) Fei Li et al. Nature Communications
- Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models
- (2021) Benjamin Bonnard et al. Scientific Reports
- Post-acute COVID-19 syndrome
- (2021) Ani Nalbandian et al. NATURE MEDICINE
- Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics
- (2021) Konstantin Chumakov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Operation Warp Speed: implications for global vaccine security
- (2021) Jerome H Kim et al. Lancet Global Health
- The Double Edge Sword of Testosterone’s Role in the COVID-19 Pandemic
- (2021) Johnny S. Younis et al. Frontiers in Endocrinology
- Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection
- (2021) Lina Ma et al. Science Immunology
- Immunothrombosis in COVID-19: Implications of Neutrophil Extracellular Traps
- (2021) Brandon Bautista-Becerril et al. Biomolecules
- Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19
- (2021) Mirjam Kiener et al. Frontiers in Medicine
- Erythrocytes identify complement activation in patients with COVID-19
- (2021) L. K. Metthew Lam et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- A longitudinal SARS-CoV-2 biorepository for COVID-19 survivors with and without post-acute sequelae
- (2021) Stephanie M. LaVergne et al. BMC INFECTIOUS DISEASES
- Mast cells: Therapeutic targets for COVID ‐19 and beyond
- (2021) Hiu Yan Lam et al. IUBMB LIFE
- Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study
- (2021) Michela Antonelli et al. LANCET INFECTIOUS DISEASES
- Metformin prevents hyperglycaemia-associated, oxidative stress-induced vascular endothelial dysfunction: essential role for the orphan nuclear receptor, Nr4a1 (Nur77).
- (2021) Vivek Krishna Pulakazhi Venu et al. MOLECULAR PHARMACOLOGY
- Covid-19 Breakthrough Infections in Vaccinated Health Care Workers
- (2021) Moriah Bergwerk et al. NEW ENGLAND JOURNAL OF MEDICINE
- Breakthrough COVID-19 infections among health care workers after two doses of ChAdOx1 nCoV-19 vaccine
- (2021) V K M Niyas et al. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
- The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
- (2021) D. A. Leach et al. Nature Communications
- Post-acute COVID-19 Syndrome Negatively Impacts Physical Function, Cognitive Function, Health-Related Quality of Life, and Participation
- (2021) Laura Tabacof et al. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
- A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
- (2021) Matthew Mahoney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The BNT162b2 vaccine effectiveness against new COVID-19 cases and complications of breakthrough cases: A nation-wide retrospective longitudinal multiple cohort analysis using individualised data
- (2021) Aharona Glatman-Freedman et al. EBioMedicine
- Post-Acute Sequelae of SARS-COVID-2 Syndrome: Just the Beginning
- (2021) Shereif H. Rezkalla et al. Cardiology Research
- Structure analysis of the receptor binding of 2019-nCoV
- (2020) Yun Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2
- (2020) Vanessa Monteil et al. CELL
- Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
- (2020) Alexandra C. Walls et al. CELL
- The Science Underlying COVID-19: Implications for the Cardiovascular System
- (2020) Peter P. Liu et al. CIRCULATION
- Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19
- (2020) Matthew A. Sparks et al. Clinical Journal of the American Society of Nephrology
- Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?
- (2020) Daniel Batlle et al. CLINICAL SCIENCE
- Androgen sensitivity gateway to COVID ‐19 disease severity
- (2020) Carlos Gustavo Wambier et al. DRUG DEVELOPMENT RESEARCH
- ACE2, COVID-19, and ACE Inhibitor and ARB Use during the Pandemic: The Pediatric Perspective
- (2020) Andrew M. South et al. HYPERTENSION
- Effects Of ARBs And ACEIs On Virus Infection, Inflammatory Status And Clinical Outcomes In COVID-19 Patients With Hypertension: A Single Center Retrospective Study
- (2020) Guang Yang et al. HYPERTENSION
- Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulation
- (2020) François Marceau et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area
- (2020) Safiya Richardson et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated
- (2020) Carlos Gustavo Wambier et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology
- (2020) Daniel Batlle et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy
- (2020) Ning Tang et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- The versatile heparin in COVID‐19
- (2020) Jecko Thachil JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- COVID-19: consider cytokine storm syndromes and immunosuppression
- (2020) Puja Mehta et al. LANCET
- Viral and host factors related to the clinical outcome of COVID-19
- (2020) Xiaonan Zhang et al. NATURE
- Severe Covid-19
- (2020) David A. Berlin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19
- (2020) Giuseppe Mancia et al. NEW ENGLAND JOURNAL OF MEDICINE
- Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19
- (2020) Harmony R. Reynolds et al. NEW ENGLAND JOURNAL OF MEDICINE
- Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young
- (2020) Thomas J. Oxley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cytokine release syndrome in severe COVID-19
- (2020) John B. Moore et al. SCIENCE
- Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis
- (2020) Elisa d’Alessandro et al. THROMBOSIS AND HAEMOSTASIS
- Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome
- (2020) Frank L van de Veerdonk et al. eLife
- Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
- (2020) Chaomin Wu et al. JAMA Internal Medicine
- Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy
- (2020) Peter M George et al. Lancet Respiratory Medicine
- C1 esterase inhibitor and the contact system in COVID‐19
- (2020) Timothy M. Thomson et al. BRITISH JOURNAL OF HAEMATOLOGY
- The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications
- (2020) James D. McFadyen et al. CIRCULATION RESEARCH
- Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies
- (2020) Georgia Ragia et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Renin-Angiotensin System Blockers and the COVID-19 Pandemic
- (2020) A.H. Jan Danser et al. HYPERTENSION
- Can existing live vaccines prevent COVID-19?
- (2020) Konstantin Chumakov et al. SCIENCE
- A new perspective for mitigation of SARS-CoV-2 infection: priming the innate immune system for viral attack
- (2020) Oren Kolodny et al. Open Biology
- A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm
- (2020) Michael R Garvin et al. eLife
- The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19)
- (2020) Pere Domingo et al. EBioMedicine
- Severe immunosuppression and not a cytokine storm characterize COVID-19 infections
- (2020) Kenneth E. Remy et al. JCI Insight
- Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis
- (2020) Jennifer G. Wilson et al. JCI Insight
- COVID‐19 critical illness pathophysiology driven by diffuse pulmonary thrombi and pulmonary endothelial dysfunction responsive to thrombolysis
- (2020) Hooman D. Poor et al. Clinical and Translational Medicine
- Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition
- (2020) Jia Yu et al. BLOOD
- Decreased Mortality in Coronavirus Disease 2019 Patients Treated With Tocilizumab: A Rapid Systematic Review and Meta-analysis of Observational Studies
- (2020) Jishnu Malgie et al. CLINICAL INFECTIOUS DISEASES
- COVID-19 is, in the end, an endothelial disease
- (2020) Peter Libby et al. EUROPEAN HEART JOURNAL
- Anticoagulation, Bleeding, Mortality, and Pathology in Hospitalized Patients With COVID-19
- (2020) Girish N. Nadkarni et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Anti‐androgens may protect against severe COVID‐19 outcomes: results from a prospective cohort study of 77 hospitalized men
- (2020) A. Goren et al. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
- Engineered ACE2 receptor traps potently neutralize SARS-CoV-2
- (2020) Anum Glasgow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- COVID-19 – A vascular disease
- (2020) Hasan K. Siddiqi et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Immunesenescence: A Predisposing Risk Factor for the Development of COVID-19?
- (2020) Jon Hazeldine et al. Frontiers in Immunology
- Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
- (2020) Ryan M. Samuel et al. Cell Stem Cell
- COVID-19: from an acute to chronic disease? Potential long-term health consequences
- (2020) Victoria Higgins et al. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
- Is spironolactone the preferred renin-angiotensin-aldosterone inhibitor for protection against COVID-19?
- (2020) Christopher S. Wilcox et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19
- (2020) Isabelle Bernard et al. Viruses-Basel
- Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets
- (2020) Krishna Sriram et al. PHYSIOLOGICAL REVIEWS
- Thromboinflammation: Challenges of Therapeutically Targeting Coagulation and other Host Defence Mechanisms
- (2019) Shaun P. Jackson et al. BLOOD
- Bat Coronaviruses in China
- (2019) Yi Fan et al. Viruses-Basel
- Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes
- (2019) Vivek Krishna Pulakazhi Venu et al. Canadian Journal of Diabetes
- 5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma
- (2019) Dylan J. Kahl et al. JOURNAL OF MEDICINAL CHEMISTRY
- Novel Variants of Angiotensin Converting Enzyme-2 of Shorter Molecular Size to Target the Kidney Renin Angiotensin System
- (2019) Jan Wysocki et al. Biomolecules
- Epithelial Sodium Channel in Aldosterone-Induced Endothelium Stiffness and Aortic Dysfunction
- (2018) Guanghong Jia et al. HYPERTENSION
- Role of Renin-Angiotensin-Aldosterone System Activation in Promoting Cardiovascular Fibrosis and Stiffness
- (2018) Guanghong Jia et al. HYPERTENSION
- Neutrophil Gelatinase-Associated Lipocalin from immune cells is mandatory for aldosterone-induced cardiac remodeling and inflammation
- (2018) Mathieu Buonafine et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Metformin reverses established lung fibrosis in a bleomycin model
- (2018) Sunad Rangarajan et al. NATURE MEDICINE
- Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress
- (2018) Mahmoud El-Daly et al. VASCULAR PHARMACOLOGY
- Aldosterone Target NGAL (Neutrophil Gelatinase–Associated Lipocalin) Is Involved in Cardiac Remodeling After Myocardial Infarction Through NFκB PathwayNovelty and Significance
- (2017) Ernesto Martínez-Martínez et al. HYPERTENSION
- The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases
- (2017) Xiao C. Li et al. PHARMACOLOGICAL RESEARCH
- Vascular mineralocorticoid receptor and blood pressure regulation
- (2015) Antoine Tarjus et al. CURRENT OPINION IN PHARMACOLOGY
- Neutrophil Gelatinase–Associated Lipocalin, a Novel Mineralocorticoid Biotarget, Mediates Vascular Profibrotic Effects of MineralocorticoidsNovelty and Significance
- (2015) Antoine Tarjus et al. HYPERTENSION
- C3a and C5a receptor antagonists ameliorate endothelial-myofibroblast transition via the Wnt/β-catenin signaling pathway in diabetic kidney disease
- (2015) Ling Li et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis
- (2015) Rui-Ming Liu et al. Redox Biology
- Complement and Its Receptors: New Insights into Human Disease
- (2014) V. Michael Holers Annual Review of Immunology
- Metformin: From Mechanisms of Action to Therapies
- (2014) Marc Foretz et al. Cell Metabolism
- Coagulation and coagulation signalling in fibrosis
- (2013) Paul F. Mercer et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Proteinase-activated Receptor-2 Transactivation of Epidermal Growth Factor Receptor and Transforming Growth Factor-β Receptor Signaling Pathways Contributes to Renal Fibrosis
- (2013) Hyunjae Chung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1)
- (2013) Koichiro Mihara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Induction of Complement C3a Receptor Responses by Kallikrein-Related Peptidase 14
- (2013) K. Oikonomopoulou et al. JOURNAL OF IMMUNOLOGY
- Long-term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial
- (2013) J. de Jager et al. JOURNAL OF INTERNAL MEDICINE
- 4-Methoxycarbonyl Curcumin: A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation
- (2013) Ying Gu et al. MEDIATORS OF INFLAMMATION
- ACE2 alterations in kidney disease
- (2013) M. J. Soler et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Proteinase-activated receptors in fibroproliferative lung disease
- (2013) Ricardo J José et al. THORAX
- Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase
- (2012) Chan Sun Park et al. BIOCHEMICAL PHARMACOLOGY
- Neutrophil Gelatinase-Associated Lipocalin Is a Novel Mineralocorticoid Target in the Cardiovascular System
- (2012) Celine Latouche et al. HYPERTENSION
- Targeting proteinase-activated receptors: therapeutic potential and challenges
- (2012) Rithwik Ramachandran et al. NATURE REVIEWS DRUG DISCOVERY
- A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis
- (2011) Sarah L. Tressel et al. EMBO Molecular Medicine
- Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2)
- (2011) Rithwik Ramachandran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human Pulmonary Microvascular Endothelial Cells Support Productive Replication of Highly Pathogenic Avian Influenza Viruses: Possible Involvement in the Pathogenesis of Human H5N1 Virus Infection
- (2011) H. Zeng et al. JOURNAL OF VIROLOGY
- Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases
- (2011) Jeffrey L. Barnes et al. KIDNEY INTERNATIONAL
- Interactions between coagulation and complement—their role in inflammation
- (2011) Katerina Oikonomopoulou et al. Seminars in Immunopathology
- Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?
- (2008) R C Chambers BRITISH JOURNAL OF PHARMACOLOGY
- Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease
- (2008) Shigeru Shibata et al. NATURE MEDICINE
- Aldosterone Induces Superoxide Generation via Rac1 Activation in Endothelial Cells
- (2007) Fumiko Iwashima et al. ENDOCRINOLOGY
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