Mineralocorticoid receptor activation and antagonism in cardiovascular disease: cellular and molecular mechanisms

Mineralocorticoid Receptor in Smooth Muscle Contributes to Pressure Overload–Induced Heart Failure

(2021) Seung Kyum Kim et al.   Circulation-Heart Failure

Eplerenone Improves Pulmonary Vascular Remodeling and Hypertension by Inhibition of the Mineralocorticoid Receptor in Endothelial Cells

(2021) Jessica Kowalski et al.   HYPERTENSION

Effect of KBP-5074 on Blood Pressure in Advanced Chronic Kidney Disease: Results of the BLOCK-CKD Study

(2021) George Bakris et al.   HYPERTENSION

Targeting inflammation in atherosclerosis — from experimental insights to the clinic

(2021) Oliver Soehnlein et al.   NATURE REVIEWS DRUG DISCOVERY

Mineralocorticoid receptor blockade with finerenone improves heart function and exercise capacity in ovariectomized mice

(2021) Marie Pieronne‐Deperrois et al.   ESC Heart Failure

Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes

(2021) Bertram Pitt et al.   NEW ENGLAND JOURNAL OF MEDICINE

A New Role for the Aldosterone/Mineralocorticoid Receptor Pathway in the Development of Mitral Valve Prolapse

(2020) Jaime Ibarrola et al.   CIRCULATION RESEARCH

MiRNA ‐181a is a novel regulator of aldosterone–mineralocorticoid receptor‐mediated cardiac remodelling

(2020) Ankita Garg et al.   EUROPEAN JOURNAL OF HEART FAILURE

Mineralocorticoid Receptors

(2020) Achim Lother   CIRCULATION RESEARCH

Beneficial Effects of Mineralocorticoid Receptor Antagonism on Myocardial Fibrosis in an Experimental Model of the Myxomatous Degeneration of the Mitral Valve

(2020) Jaime Ibarrola et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2020 International Society of Hypertension global hypertension practice guidelines

(2020) Thomas Unger et al.   JOURNAL OF HYPERTENSION

Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine

(2020) Rajiv Agarwal et al.   EUROPEAN HEART JOURNAL

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

(2020) George L. Bakris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Finerenone and Cardiovascular Outcomes in Patients with Chronic Kidney Disease and Type 2 Diabetes

(2020) Gerasimos Filippatos et al.   CIRCULATION

Selective deletion of endothelial mineralocorticoid receptor protects from vascular dysfunction in sodium-restricted female mice

(2020) Jessica L. Faulkner et al.   Biology of Sex Differences

Esaxerenone: First Global Approval

(2019) Sean Duggan   DRUGS

Small animal models of heart failure

(2019) Christian Riehle et al.   CARDIOVASCULAR RESEARCH

Endothelial Mineralocorticoid Receptors Contribute to Vascular Inflammation in Atherosclerosis in a Sex-Specific Manner

(2019) M. Elizabeth Moss et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Double-Blind Randomized Phase 3 Study Comparing Esaxerenone (CS-3150) and Eplerenone in Patients With Essential Hypertension (ESAX-HTN Study)

(2019) Sadayoshi Ito et al.   HYPERTENSION

Heart Failure with Preserved Ejection Fraction

(2018) James D. Gladden et al.   Annual Review of Medicine

The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis

(2018) Charlotte D C C van der Heijden et al.   CARDIOVASCULAR RESEARCH

Smooth Muscle Cell–Mineralocorticoid Receptor as a Mediator of Cardiovascular Stiffness With AgingNovelty and Significance

(2018) Seung Kyum Kim et al.   HYPERTENSION

Neutrophil Gelatinase-Associated Lipocalin from immune cells is mandatory for aldosterone-induced cardiac remodeling and inflammation

(2018) Mathieu Buonafine et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mineralocorticoid receptor antagonism improves diastolic dysfunction in chronic kidney disease in mice

(2018) Benjamin Bonnard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Endothelial mineralocorticoid receptor ablation does not alter blood pressure, kidney function or renal vessel contractility

(2018) Sidsel B. Laursen et al.   PLoS One

NEDD9 targetsCOL3A1to promote endothelial fibrosis and pulmonary arterial hypertension

(2018) Andriy O. Samokhin et al.   Science Translational Medicine

Evidence for the use of mineralocorticoid receptor antagonists in the treatment of coronary artery disease and post-angioplasty restenosis

(2018) Jochen Dutzmann et al.   VASCULAR PHARMACOLOGY

Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension

(2018) Mario Boehm et al.   BMC Pulmonary Medicine

Incidence of Atrial Fibrillation and Mineralocorticoid Receptor Activity in Patients With Medically and Surgically Treated Primary Aldosteronism

(2018) Gregory L. Hundemer et al.   JAMA Cardiology

Impact of mineralocorticoid receptor antagonists on the risk of sudden cardiac death in patients with heart failure and left-ventricular systolic dysfunction: an individual patient-level meta-analysis of three randomized-controlled trials

(2018) Xavier Rossello et al.   Clinical Research in Cardiology

Endothelial cell mineralocorticoid receptors oppose VEGF-induced gene expression and angiogenesis

(2018) Achim Lother et al.   JOURNAL OF ENDOCRINOLOGY

Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing

(2018) Daniela Fraccarollo et al.   HYPERTENSION

Regulation of Atrial Fibrosis by the Bone

(2018) Yi Yi et al.   HYPERTENSION

Mineralocorticoid Receptor Deficiency in T Cells Attenuates Pressure Overload–Induced Cardiac Hypertrophy and Dysfunction Through Modulating T-Cell ActivationNovelty and Significance

(2017) Chao Li et al.   HYPERTENSION

Essential role of ICAM-1 in aldosterone-induced atherosclerosis

(2017) Vincenzo Marzolla et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor and NaCl transport mechanisms in the renal distal nephron

(2017) Shigeru Shibata   JOURNAL OF ENDOCRINOLOGY

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The role of the mineralocorticoid receptor in the vasculature

(2017) Jennifer J DuPont et al.   JOURNAL OF ENDOCRINOLOGY

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development

(2017) Peter Kolkhof et al.   JOURNAL OF ENDOCRINOLOGY

Eplerenone Reduces Atrial Fibrillation Burden Without Preventing Atrial Electrical Remodeling

(2017) Yoshio Takemoto et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Spironolactone Metabolites in TOPCAT — New Insights into Regional Variation

(2017) Simon de Denus et al.   NEW ENGLAND JOURNAL OF MEDICINE

The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury

(2017) Jochen Dutzmann et al.   PLoS One

Efficacy and Safety of Spironolactone in Acute Heart Failure

(2017) Javed Butler et al.   JAMA Cardiology

Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Neointimal Hyperplasia and Suppresses Macrophage Inflammation Through SGK1-AP1/NF-κB PathwaysSignificance

(2016) Jian-Yong Sun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A randomized controlled study of finerenone vs. eplerenone in patients with worsening chronic heart failure and diabetes mellitus and/or chronic kidney disease

(2016) Gerasimos Filippatos et al.   EUROPEAN HEART JOURNAL

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2016) Piotr Ponikowski et al.   EUROPEAN HEART JOURNAL

Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension

(2016) Laurent Calvier et al.   HEART

Vascular Smooth Muscle Mineralocorticoid Receptor Contributes to Coronary and Left Ventricular Dysfunction After Myocardial InfarctionNovelty and Significance

(2016) Alexandre Gueret et al.   HYPERTENSION

Vascular Mineralocorticoid Receptors

(2016) Achim Lother et al.   HYPERTENSION

Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Atherosclerosis by Affecting Foam Cell Formation and Efferocytosis

(2016) Zhu-Xia Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Aldosterone Antagonism on Exercise Tolerance in Heart Failure With Preserved Ejection Fraction

(2016) Wojciech Kosmala et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Early Aldosterone Blockade in Acute Myocardial Infarction

(2016) Farzin Beygui et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitral valve disease—current management and future challenges

(2016) Rick A Nishimura et al.   LANCET

Pharmacology of heart failure: From basic science to novel therapies

(2016) Achim Lother et al.   PHARMACOLOGY & THERAPEUTICS

Mineralocorticoids in the Heart and Vasculature: New Insights for Old Hormones

(2015) Achim Lother et al.   Annual Review of Pharmacology and Toxicology

Galectin-3 Blockade Inhibits Cardiac Inflammation and Fibrosis in Experimental Hyperaldosteronism and HypertensionNovelty and Significance

(2015) Ernesto Martínez-Martínez et al.   HYPERTENSION

Endothelial Mineralocorticoid Receptor Deletion Prevents Diet-Induced Cardiac Diastolic Dysfunction in Females

(2015) Guanghong Jia et al.   HYPERTENSION

Neutrophil Gelatinase–Associated Lipocalin, a Novel Mineralocorticoid Biotarget, Mediates Vascular Profibrotic Effects of MineralocorticoidsNovelty and Significance

(2015) Antoine Tarjus et al.   HYPERTENSION

Deoxycorticosterone Acetate/Salt–Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood PressureNovelty and Significance

(2015) Achim Lother et al.   HYPERTENSION

Endothelial Mineralocorticoid Receptors Differentially Contribute to Coronary and Mesenteric Vascular Function Without Modulating Blood PressureNovelty and Significance

(2015) Katelee Barrett Mueller et al.   HYPERTENSION

Mineralocorticoid Receptor Antagonism Treats Obesity-Associated Cardiac Diastolic Dysfunction

(2015) S. B. Bender et al.   HYPERTENSION

Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet–Induced Arterial Stiffening in Female MiceNovelty and Significance

(2015) Vincent G. DeMarco et al.   HYPERTENSION

The Impact of Galectin-3 Inhibition on Aldosterone-Induced Cardiac and Renal Injuries

(2015) Laurent Calvier et al.   JACC-Heart Failure

Upregulation of Steroidogenic Acute Regulatory Protein by Hypoxia Stimulates Aldosterone Synthesis in Pulmonary Artery Endothelial Cells to Promote Pulmonary Vascular Fibrosis

(2014) Bradley A. Maron et al.   CIRCULATION

Early eplerenone treatment in patients with acute ST-elevation myocardial infarction without heart failure: The Randomized Double-Blind Reminder Study

(2014) G. Montalescot et al.   EUROPEAN HEART JOURNAL

Protective effects of spironolactone against anthracycline-induced cardiomyopathy

(2014) Mahmut Akpek et al.   EUROPEAN JOURNAL OF HEART FAILURE

Endothelial Cell Mineralocorticoid Receptors Regulate Deoxycorticosterone/Salt-Mediated Cardiac Remodeling and Vascular Reactivity But Not Blood Pressure

(2014) Amanda J. Rickard et al.   HYPERTENSION

Effects of Spironolactone Treatment in Elderly Women With Heart Failure and Preserved Left Ventricular Ejection Fraction

(2014) Karla M. Kurrelmeyer et al.   JOURNAL OF CARDIAC FAILURE

Spironolactone for Heart Failure with Preserved Ejection Fraction

(2014) Bertram Pitt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effectiveness of Spironolactone Plus Ambrisentan for Treatment of Pulmonary Arterial Hypertension (from the [ARIES] Study 1 and 2 Trials)

(2013) Bradley A. Maron et al.   AMERICAN JOURNAL OF CARDIOLOGY

Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension

(2013) Ioana R. Preston et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Aldosterone Promotes Vascular Remodeling by Direct Effects on Smooth Muscle Cell Mineralocorticoid Receptors

(2013) Dafina Pruthi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity

(2013) Nicola Schäfer et al.   EUROPEAN HEART JOURNAL

Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial

(2013) Bertram Pitt et al.   EUROPEAN HEART JOURNAL

Smooth Muscle Cell Mineralocorticoid Receptors Are Mandatory for Aldosterone–Salt to Induce Vascular Stiffness

(2013) Guillaume Galmiche et al.   HYPERTENSION

Effect of Spironolactone on Diastolic Function and Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction

(2013) Frank Edelmann et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Aldosterone Inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension

(2012) Bradley A. Maron et al.   CIRCULATION

Macrophage Mineralocorticoid Receptor Signaling Plays a Key Role in Aldosterone-Independent Cardiac Fibrosis

(2012) Laura A. Bienvenu et al.   ENDOCRINOLOGY

Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study

(2012) Bradley A. Maron et al.   EUROPEAN JOURNAL OF HEART FAILURE

Cardiomyocyte Mineralocorticoid Receptors Are Essential for Deoxycorticosterone/Salt-Mediated Inflammation and Cardiac Fibrosis

(2012) Amanda J. Rickard et al.   HYPERTENSION

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

(2012) Amy McCurley et al.   NATURE MEDICINE

Aldosterone Regulates Vascular Gene Transcription via Oxidative Stress–Dependent and –Independent Pathways

(2011) Brenna G. Newfell et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of Cardiomyocyte Mineralocorticoid Receptor Ameliorates Adverse Remodeling After Myocardial Infarction

(2011) Daniela Fraccarollo et al.   CIRCULATION

Ablation of Mineralocorticoid Receptors in Myocytes But Not in Fibroblasts Preserves Cardiac Function

(2011) Achim Lother et al.   HYPERTENSION

Role of mineralocorticoid receptor on atrial structural remodeling and inducibility of atrial fibrillation in hypertensive rats

(2011) Shinpei Kimura et al.   HYPERTENSION RESEARCH

The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure

(2010) Aurelie Nguyen Dinh Cat et al.   FASEB JOURNAL

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

(2010) Michael G. Usher et al.   JOURNAL OF CLINICAL INVESTIGATION

Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

(2010) Faiez Zannad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deletion of Mineralocorticoid Receptors From Macrophages Protects Against Deoxycorticosterone/Salt-Induced Cardiac Fibrosis and Increased Blood Pressure

(2009) Amanda J. Rickard et al.   HYPERTENSION

Functional Mineralocorticoid Receptors in Human Vascular Endothelial Cells Regulate Intercellular Adhesion Molecule-1 Expression and Promote Leukocyte Adhesion

(2008) Massimiliano Caprio et al.   CIRCULATION RESEARCH

Immediate Mineralocorticoid Receptor Blockade Improves Myocardial Infarct Healing by Modulation of the Inflammatory Response

(2008) Daniela Fraccarollo et al.   HYPERTENSION