Acetyl-CoA Carboxylases and Diseases

Faster lipid β‐oxidation rate by acetyl‐CoA carboxylase 2 inhibition alleviates high‐glucose‐induced insulin resistance via SIRT1/PGC‐1α in human podocytes

(2021) Qinglian Wang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Selective acetyl-CoA carboxylase 1 inhibitor improves hepatic steatosis and hepatic fibrosis in a pre-clinical NASH model

(2021) Yumiko Okano Tamura et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials

(2021) Roberto A. Calle et al.   NATURE MEDICINE

Targeting ACC for NASH resolution

(2021) Xiao-Jing Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies

(2020) Fumiaki Imamura et al.   PLOS MEDICINE

Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progression

(2020) Ji Hye Yang et al.   Life Science Alliance

The return of malonyl-CoA to the brain: Cognition and other stories

(2020) Rut Fadó et al.   PROGRESS IN LIPID RESEARCH

Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation

(2019) Koji Ueda et al.   Oncotarget

PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside

(2019) Ali S. Alzahrani   SEMINARS IN CANCER BIOLOGY

The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma

(2019) Kun Li et al.   PeerJ

GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH)

(2019) Naim Alkhouri et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors

(2019) Leyuan Chen et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state

(2019) Leanne Hodson et al.   Nature Reviews Endocrinology

WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice

(2019) Ying-sheng Gao et al.   ACTA PHARMACOLOGICA SINICA

Metformin prevents the pathological browning of subcutaneous white adipose tissue

(2019) Christopher Auger et al.   Molecular Metabolism

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer

(2019) Marteinn Thor Snaebjornsson et al.   Cell Metabolism

Structural Characterization of i-Motif Structure in the Human Acetyl-CoA Carboxylase 1 Gene Promoters and Their Role in the Regulation of Gene Expression

(2018) Mangesh H. Kaulage et al.   CHEMBIOCHEM

Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis

(2018) Eric J. Lawitz et al.   Clinical Gastroenterology and Hepatology

Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor

(2018) SoRi Jang et al.   FEBS LETTERS

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+–NFAT signaling

(2018) Joyce V. Lee et al.   GENES & DEVELOPMENT

TOFA induces cell cycle arrest and apoptosis in ACHN and 786-O cells through inhibiting PI3K/Akt/mTOR pathway

(2018) Dejiao He et al.   Journal of Cancer

CAMKK2 promotes prostate cancer independently of AMPK via increased lipogenesis

(2018) Lucy Penfold et al.   CANCER RESEARCH

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

(2018) James S.V. Lally et al.   Cell Metabolism

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

(2018) Ulrike Bruning et al.   Cell Metabolism

Structural basis for regulation of human acetyl-CoA carboxylase

(2018) Moritz Hunkeler et al.   NATURE

Elucidating the novel BRCA1 function as a non-genomic metabolic restraint in ER-positive breast cancer cell lines

(2018) Moses Koobotse et al.   Oncotarget

n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review

(2018) Meng Wang et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

(2018) James Cantley et al.   DIABETOLOGIA

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of Fatty Acid Synthesis Induces Apoptosis of Human Pancreatic Cancer Cells

(2016) KOJI NISHI et al.   ANTICANCER RESEARCH

Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients

(2016) Ming-Da Wang et al.   HEPATOLOGY

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

(2016) Geraldine Harriman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novolipogenesis in the liver in health and disease: more than just a shunting yard for glucose

(2015) Francis W. B. Sanders et al.   BIOLOGICAL REVIEWS

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer

(2015) Jia Wei et al.   NATURE

Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells

(2015) Bruna Corominas-Faja et al.   Oncotarget

Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

(2014) David A. Griffith et al.   JOURNAL OF MEDICINAL CHEMISTRY

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation

(2014) Jenny D.Y. Chow et al.   Molecular Metabolism

Targeting PI3K/Akt/mTOR Signaling in Cancer

(2014) Camillo Porta et al.   Frontiers in Oncology

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

The Three-Dimensional Structure of the Biotin Carboxylase-Biotin Carboxyl Carrier Protein Complex of E. coli Acetyl-CoA Carboxylase

(2013) Tyler C. Broussard et al.   STRUCTURE

Structural classification of biotin carboxyl carrier proteins

(2012) Yingfei Chen et al.   BIOTECHNOLOGY LETTERS

Acetyl-CoA Carboxylase 2−/−Mutant Mice are Protected against Fatty Liver under High-fat, High-carbohydrate Dietary andde NovoLipogenic Conditions

(2012) Lutfi Abu-Elheiga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetyl-CoA Carboxylase Regulates Global Histone Acetylation

(2012) Luciano Galdieri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

Targeting Acetyl-CoA Carboxylases: Small Molecular Inhibitors and their Therapeutic Potential

(2012) Di-Xian Luo et al.   Recent Patents on Anti-Cancer Drug Discovery

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats

(2011) Christoffer Bengtsson et al.   BIOORGANIC & MEDICINAL CHEMISTRY

TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status

(2011) Natalya V. Guseva et al.   CANCER BIOLOGY & THERAPY

The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

(2011) Wing-Hang Tong et al.   CANCER CELL

Positive Feedback Loop Between PI3K-Akt-mTORC1 Signaling and the Lipogenic Pathway Boosts Akt Signaling: Induction of the Lipogenic Pathway by a Melanoma Antigen

(2011) Y. Yamauchi et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Labeled Acetate as a Marker of Astrocytic Metabolism

(2011) Matthias T Wyss et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

(2010) E. Rysman et al.   CANCER RESEARCH

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake

(2010) D. P. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist

(2009) Kevin P. Madauss et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK

(2009) Yong Soon Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

(4-Piperidinyl)-piperazine: A new platform for acetyl-CoA carboxylase inhibitors

(2009) Tomomichi Chonan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet

(2009) M. Schreurs et al.   DIABETES OBESITY & METABOLISM

Regulatory enzymes of mitochondrial β-oxidation as targets for treatment of the metabolic syndrome

(2009) M. Schreurs et al.   Obesity Reviews

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK

(2009) Natalia Scaglia et al.   PLoS One

Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice

(2008) M. Faadiel Essop et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Malonyl-CoA, a Key Signaling Molecule in Mammalian Cells

(2008) David Saggerson   Annual Review of Nutrition

ChREBP: A Glucose-activated Transcription Factor Involved in the Development of Metabolic Syndrome

(2008) Katsumi IIZUKA et al.   ENDOCRINE JOURNAL

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH

Biotinoyl domain of human acetyl-CoA carboxylase: Structural insights into the carboxyl transfer mechanism

(2008) Chung-Kyung Lee et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS