Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva

(2015) Kyosuke Hino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ACVR1 R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

(2015) Sarah J. Hatsell et al.   Science Translational Medicine

A muscle stem cell for every muscle: variability of satellite cell biology among different muscle groups

(2015) Matthew E. Randolph et al.   Frontiers in Aging Neuroscience

Hypoxia-Inducible Factors Have Distinct and Stage-Specific Roles during Reprogramming of Human Cells to Pluripotency

(2014) Julie Mathieu et al.   Cell Stem Cell

Apigenin inhibits osteoblastogenesis and osteoclastogenesis and prevents bone loss in ovariectomized mice

(2014) Tadashi Goto et al.   CYTOTECHNOLOGY

ACVR1 mutations and the genomic landscape of pediatric diffuse glioma

(2014) Gelareh Zadeh et al.   NATURE GENETICS

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

(2014) Gang Wu et al.   NATURE GENETICS

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

(2014) Pawel Buczkowicz et al.   NATURE GENETICS

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

(2014) Kathryn R Taylor et al.   NATURE GENETICS

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

(2014) Adam M Fontebasso et al.   NATURE GENETICS

BMP signaling requires retromer-dependent recycling of the type I receptor

(2014) R. J. Gleason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alk2 Regulates Early Chondrogenic Fate in Fibrodysplasia Ossificans Progressiva Heterotopic Endochondral Ossification

(2014) Andria L. Culbert et al.   STEM CELLS

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster

(2013) Chloe Thomas et al.   DEVELOPMENTAL BIOLOGY

Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway

(2012) Minako Aoyama et al.   DEVELOPMENTAL CELL

Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva

(2012) Apirat Chaikuad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AnAcvr1R206H knock-in mouse has fibrodysplasia ossificans progressiva

(2012) Salin A Chakkalakal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

(2012) Anja Zeigerer et al.   NATURE

Hypoxia-driven pathways in bone development, regeneration and disease

(2012) Christa Maes et al.   Nature Reviews Rheumatology

A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor

(2011) Kyeong Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Human Early Fracture Hematoma Is Characterized by Inflammation and Hypoxia

(2011) Paula Kolar et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Hyperactive BMP signaling induced by ALK2R206Hrequires type II receptor function in aDrosophilamodel for classic fibrodysplasia ossificans progressiva

(2011) Viet Q. Le et al.   DEVELOPMENTAL DYNAMICS

Synergistic Inhibition of Endochondral Bone Formation by Silencing Hif1α and Runx2 in Trauma-induced Heterotopic Ossification

(2011) Lin Lin et al.   MOLECULAR THERAPY

Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists

(2011) Kengo Shimono et al.   NATURE MEDICINE

The bone morphogenetic protein antagonist noggin protects white matter after perinatal hypoxia–ischemia

(2011) Maria L.V. Dizon et al.   NEUROBIOLOGY OF DISEASE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Id1 Maintains Embryonic Stem Cell Self-Renewal by Up-Regulation of Nanog and Repression of Brachyury Expression

(2011) Elizabeth E. Romero-Lanman et al.   STEM CELLS AND DEVELOPMENT

Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro

(2010) Fei Tian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia, HIFs and bone development

(2010) Elisa Araldi et al.   BONE

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

The novel endosomal membrane protein Ema interacts with the class C Vps–HOPS complex to promote endosomal maturation

(2010) Sungsu Kim et al.   JOURNAL OF CELL BIOLOGY

HIF-1 and HIF-2 transcription factors — Similar but not identical

(2010) Agnieszka Loboda et al.   MOLECULES AND CELLS

Geochemical evidence for widespread euxinia in the Later Cambrian ocean

(2010) Benjamin C. Gill et al.   NATURE

Conversion of vascular endothelial cells into multipotent stem-like cells

(2010) Damian Medici et al.   NATURE MEDICINE

Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans

(2010) Cormac T. Taylor et al.   PHYSIOLOGY

Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

(2009) Yoshinori Yoshida et al.   Cell Stem Cell

Inhibiting the Hypoxia Response for Cancer Therapy: The New Kid on the Block

(2009) M. Y. Koh et al.   CLINICAL CANCER RESEARCH

The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling

(2009) Frederick S. Kaplan et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The Role of Hypoxia in Development of the Mammalian Embryo

(2009) Sally L. Dunwoodie   DEVELOPMENTAL CELL

miR-210 promotes osteoblastic differentiation through inhibition ofAcvR1b

(2009) Yosuke Mizuno et al.   FEBS LETTERS

Bone morphogenetic protein 4 is induced in hepatocellular carcinoma by hypoxia and promotes tumour progression

(2009) Ulrike Maegdefrau et al.   JOURNAL OF PATHOLOGY

Oxygen sensor boosts growth factor signaling

(2009) Mien-Chie Hung et al.   NATURE MEDICINE

Regulation of endocytosis via the oxygen-sensing pathway

(2009) Yi Wang et al.   NATURE MEDICINE

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Endocytic regulation of TGF-β signaling

(2008) Ye-Guang Chen   CELL RESEARCH

Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1

(2008) Frederick S. Kaplan et al.   HUMAN MUTATION

Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)

(2008) Frederick S. Kaplan et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Protective effect of apigenin on ovariectomy-induced bone loss in rats

(2008) Jeong A Park et al.   LIFE SCIENCES

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

BMP type I receptor inhibition reduces heterotopic ossification

(2008) Paul B Yu et al.   NATURE MEDICINE

The role of oxygen availability in embryonic development and stem cell function

(2008) M. Celeste Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chondrogenic differentiation of growth factor-stimulated precursor cells in cartilage repair tissue is associated with increased HIF-1α activity

(2008) K. Gelse et al.   OSTEOARTHRITIS AND CARTILAGE

Activation of the hypoxia-inducible factor-1  pathway accelerates bone regeneration

(2008) C. Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA