ACVR1 R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B

(2015) Oddrun Elise Olsen et al.   Cell Communication and Signaling

Loss of BMPR2 leads to high bone mass due to increased osteoblast activity

(2015) J. W. Lowery et al.   JOURNAL OF CELL SCIENCE

Mutant Activin-Like Kinase 2 in Fibrodysplasia Ossificans Progressiva are Activated via T203 by BMP Type II Receptors

(2015) Mai Fujimoto et al.   MOLECULAR ENDOCRINOLOGY

Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2

(2014) Mai Fujimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fibrodysplasia Ossificans Progressiva-related Activated Activin-like Kinase Signaling Enhances Osteoclast Formation during Heterotopic Ossification in Muscle Tissues

(2014) Masato Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of ActRIIB Signaling Triggers Muscle Fatigability and Metabolic Myopathy

(2014) Karima Relizani et al.   MOLECULAR THERAPY

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes

(2014) L. E. Macdonald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

(2014) A. J. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alk2 Regulates Early Chondrogenic Fate in Fibrodysplasia Ossificans Progressiva Heterotopic Endochondral Ossification

(2014) Andria L. Culbert et al.   STEM CELLS

Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation

(2013) J. Bagarova et al.   MOLECULAR AND CELLULAR BIOLOGY

Conditionals by inversion provide a universal method for the generation of conditional alleles

(2013) Aris N. Economides et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis

(2012) F. S. Kaplan et al.   Disease Models & Mechanisms

Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva

(2012) Apirat Chaikuad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AnAcvr1R206H knock-in mouse has fibrodysplasia ossificans progressiva

(2012) Salin A Chakkalakal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

In vitro Analyses of the Dysregulated R206H ALK2 Kinase-FKBP12 Interaction Associated with Heterotopic Ossification in FOP

(2011) Jay C. Groppe et al.   CELLS TISSUES ORGANS

When versatility matters: activins/inhibins as key regulators of immunity

(2011) G R Aleman-Muench et al.   IMMUNOLOGY AND CELL BIOLOGY

Fibrodysplasia Ossificans Progressiva: Clinical and Genetic Aspects

(2011) Robert J Pignolo et al.   Orphanet Journal of Rare Diseases

Characterization of the Ligand Binding Functionality of the Extracellular Domain of Activin Receptor Type IIB

(2010) Dianne Sako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-Dose, Randomized, Double-Blind, Placebo-Controlled Study of ACE-011 (ActRIIA-IgG1) in Postmenopausal Women*

(2008) Jon Ruckle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Proteomic Identification and Functional Validation of Activins and Bone Morphogenetic Protein 11 as Candidate Novel Muscle Mass Regulators

(2008) Tatyana A. Souza et al.   MOLECULAR ENDOCRINOLOGY

BMP type I receptor inhibition reduces heterotopic ossification

(2008) Paul B Yu et al.   NATURE MEDICINE