Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis

Inhibition of HSP90 S‐nitrosylation Alleviates Cardiac Fibrosis via TGFβ/SMAD3 Signaling Pathway

(2021) Xiyue Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

S-nitrosylation of Hsp90 promotes cardiac hypertrophy in mice through GSK3β signaling

(2021) Shuang Zhao et al.   ACTA PHARMACOLOGICA SINICA

S-Nitrosylation of Muscle LIM Protein Facilitates Myocardial Hypertrophy Through Toll-Like Receptor 3-Mediated Receptor-Interacting ProteinKinase 3 and NLRP3 Inflammasome Activation

(2020) Xin Tang et al.   CIRCULATION

Post-translational modifications of Hsp90 and translating the chaperone code

(2020) Sarah J. Backe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The protein S-nitrosylation of splicing and translational machinery in vascular endothelial cells is susceptible to oxidative stress induced by oxidized low-density lipoprotein

(2019) Xiaohui Xu et al.   Journal of Proteomics

Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes

(2019) Celine Souilhol et al.   Nature Reviews Cardiology

Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1

(2019) Wanping Xu et al.   Nature Communications

S-Nitrosylation of Plastin-3 Exacerbates Thoracic Aortic Dissection Formation via Endothelial Barrier Dysfunction

(2019) Lihong Pan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

eNOS S-nitrosylation mediated OxLDL-induced endothelial dysfunction via increasing the interaction of eNOS with β‑catenin

(2018) Wan Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endothelial microRNAs regulating the NF-κB pathway and cell adhesion molecules during inflammation

(2018) Liang Zhong et al.   FASEB JOURNAL

Nitric oxide signalling in cardiovascular health and disease

(2018) Charlotte Farah et al.   Nature Reviews Cardiology

Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling

(2018) Olivier Genest et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation

(2016) Liping Xie et al.   DIABETES

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism

(2016) Andrea Schulze et al.   Nature Chemical Biology

Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors

(2014) Mehdi Mollapour et al.   MOLECULAR CELL

Oxidative stress and vascular inflammation in aging

(2013) Mariam El Assar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thioredoxin and Thioredoxin Reductase in Relation to Reversible S-Nitrosylation

(2012) Rajib Sengupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Modulation of the Cochaperone AHA1 Regulates Heat-Shock Protein 90 and Endothelial NO Synthase Activation by Vascular Endothelial Growth Factor

(2012) Fanny Desjardins et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine

(2012) Wanping Xu et al.   MOLECULAR CELL

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

(2011) Mehdi Mollapour et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Role of Nitric Oxide on Endothelial Function

(2011) Dimitris Tousoulis et al.   Current Vascular Pharmacology

Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity

(2011) Mehdi Mollapour et al.   MOLECULAR CELL

S -Nitrosylation in Cardiovascular Signaling

(2010) Brian Lima et al.   CIRCULATION RESEARCH

Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis

(2010) Atanas V. Koulov et al.   MOLECULAR BIOLOGY OF THE CELL

S-Nitrosylation of β-Catenin by eNOS-Derived NO Promotes VEGF-Induced Endothelial Cell Permeability

(2010) Sébastien Thibeault et al.   MOLECULAR CELL

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

(2010) Marco Retzlaff et al.   MOLECULAR CELL

Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function

(2010) Mehdi Mollapour et al.   MOLECULAR CELL

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hsp90 is regulated by a switch point in the C-terminal domain

(2009) Marco Retzlaff et al.   EMBO REPORTS