Article
Microbiology
Likai Ji, Qianqian Liu, Na Wang, Yan Wang, Jianhe Sun, Yaxian Yan
Summary: This study demonstrates that STAU1 plays a crucial role in maintaining the binding of RIG-I/MDA5 to viral dsRNA in pigs and can suppress viral proliferation.
VETERINARY MICROBIOLOGY
(2022)
Article
Microbiology
Boonyanudh Jiyarom, Stefanos Giannakopoulos, Daniel P. Strange, Nataliya Panova, Michael Gale Jr, Saguna Verma
Summary: This study demonstrates the crucial role of RIG-I-like receptors in sensing ZIKV in Sertoli cells, and reveals a novel role of BMP6 in modulating innate immune and antiviral response in the testes.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Fisheries
Qiuju Liu, Menglu Zhang, Jie Wang, Jianjian Zhang, Zhaofei Wang, Jingjiao Ma, Yaxian Yan, Jianhe Sun, Yuqiang Cheng
Summary: In this study, the first bat IRF1 gene was cloned, and its functions in IFN induction were preliminarily identified.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Fisheries
Feiyu Fu, Qi Shao, Jie Wang, Jianjian Zhang, Zhaofei Wang, Jingjiao Ma, Yaxian Yan, Yuqiang Cheng, Jianhe Sun
Summary: This study analyzed the cloning and function of BatMAVS, the articulatory protein in bats' immune response against RNA viruses. It was found that BatMAVS plays a crucial role in regulating the interferon response and inhibiting viral replication.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Microbiology
Feiyu Fu, Qi Shao, Jianjian Zhang, Jie Wang, Zhaofei Wang, Jingjiao Ma, Yaxian Yan, Jianhe Sun, Yuqiang Cheng
Summary: The study demonstrates the crucial role of STING in mediating interferon responses and anti-RNA virus infection in bat hosts.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Morgan Brisse, Qinfeng Huang, Mizanur Rahman, Da Di, Yuying Liang, Hinh Ly
Summary: The study demonstrates the crucial roles of MDA5 and RIG-I in controlling Pichinde virus infection in mice. Knockout of MDA5 or both MDA5 and RIG-I results in significantly higher virus titers and lower early IFN-I expression following PICV infection, but a later and heightened adaptive immune response for clearance of the infection is observed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Qi Shao, Feiyu Fu, Pei Zhu, Xiangyu Yu, Jie Wang, Zhaofei Wang, Jingjiao Ma, Hengan Wang, Yaxian Yan, Yuqiang Cheng, Jianhe Sun
Summary: The pigeon MDA5 gene was cloned and studied, and it was found that MDA5 plays an important role in innate immunity by activating the interferon signal pathway to inhibit viral replication in pigeons.
Review
Cell Biology
Rongzhao Zhang, Zhixin Li, Yan-Dong Tang, Chenhe Su, Chunfu Zheng
Summary: Guanylate-binding proteins (GBPs) play important roles in antiviral innate immunity, but our understanding of their molecular mechanisms in viral infection is limited. Research faces discrepancies and challenges in exploring the functions of GBPs in regulating antiviral innate immunity.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Engineering, Environmental
Chao Wang, Wenjiao Wu, Zefen Pang, Jiaxin Liu, Jianxiang Qiu, Tiangang Luan, Jiewei Deng, Zhixin Fang
Summary: Microplastics (MPs) are a type of emerging pollutants that pose a potential threat to human health. This study found that polystyrene microplastics (PS) can promote influenza A virus (IAV) infection. The PS can enrich the virus, enter cells through endocytosis, and downregulate the expression of IFITM3. Furthermore, PS can also down-regulate IRF3 and its active form P-IRF3 by inhibiting TBK1 phosphorylation activation, thereby reducing IFN-beta expression and affecting the cellular innate antiviral immune system.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Fisheries
Mengmeng Wang, Bin Yang, Tao Liu, Pengfei Li, Shangjie Bai, Zhengyang Zhou, Xiang Liu, Maosheng He, Fei Ling, Gaoxue Wang
Summary: The largemouth bass virus (LMBV) is a common pathogen in aquaculture, and the lack of effective treatment methods poses significant challenges to the development of the largemouth bass industry. This study evaluated the inhibitory potential and underlying mechanisms of adamantoyl chloride (AdCl) against LMBV, and confirmed its anti-viral activities both in vitro and in vivo.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Virology
Liying Jin, Mengna Chen, Meiqin Xiang, Zhongxin Guo
Summary: The article reviews the mechanism of RNAi-based antiviral innate immunity in plants and the counteractions of various viral suppressors of RNA silencing (VSRs). The authors also propose some critical challenges in the field and suggest that further elucidating conserved antiviral innate immunity may provide a broad spectrum of antiviral strategies in the future.
Review
Immunology
Nighat Perveen, Khalid Muhammad, Sabir Bin Muzaffar, Tean Zaheer, Nayla Munawar, Bojan Gajic, Olivier Andre Sparagano, Uday Kishore, Arve Lee Willingham
Summary: Haematophagous arthropods can carry various pathogens and transmit them to humans and animals, making it important to study their relationship with viruses. Insects have an innate immune system that helps them fight infections. The cellular components of haemolymph, called haemocytes, play a central role in the insect immune system. Mosquitoes and ticks, blood-feeding arthropods, can transmit viral pathogens to their hosts. Despite the arthropod vectors' complex immune response, the viruses can still survive and be transmitted. A multidisciplinary approach is needed to control ectoparasite infestations and prevent vector-borne transmission of viral pathogens to humans and animals.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tingting Feng, Hao Tong, Zhihao Ming, Lei Deng, Jiayan Liu, Jiahui Wu, Zhengrong Chen, Yongdong Yan, Jianfeng Dai
Summary: The study shows that matrix metalloproteinase 3 (MMP3) has antiviral activities and enhances antiviral immune responses during viral infection. MMP3 deficiency in mice leads to increased susceptibility to viral infection and compromised antiviral immune responses. The translocation of MMP3 and its impact on NF-kappa B activity may be involved in its antiviral mechanism.
ANTIVIRAL RESEARCH
(2022)
Article
Virology
Veronika Krchlikova, Tomas Hron, Martin Tesicky, Tao Li, Jiri Hejnar, Michal Vinkler, Daniel Elleder
Summary: The study identified independent disruptions of the MDA5 gene in two unrelated avian lineages, with no compensatory evolution observed in the RIG-I gene. The pseudogenization of MDA5 may have important functional effects on immune responsiveness in these two avian clades.
Article
Fisheries
Qian Li, Lixia Xie, Jiaji Pan, Yixuan He, Enhui Wang, Hui Wu, Jun Xiao, Hao Feng
Summary: This study cloned and characterized the homolog of RIOK3 (bcRIOK3) from black carp and found that it plays an important role in the antiviral immunity. The results showed that bcRIOK3 regulates the interferon signaling pathway, reducing sensitivity to viruses and enhancing host resistance.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)