Repeated MDA5 Gene Loss in Birds: An Evolutionary Perspective

ModFOLD8: accurate global and local quality estimates for 3D protein models

(2021) Liam J McGuffin et al.   NUCLEIC ACIDS RESEARCH

Convergent losses of TLR5 suggest altered extracellular flagellin detection in four mammalian lineages

(2020) Virag Sharma et al.   MOLECULAR BIOLOGY AND EVOLUTION

Widespread patterns of gene loss in the evolution of the animal kingdom

(2020) Cristina Guijarro-Clarke et al.   Nature Ecology & Evolution

Targeted Knockout of MDA5 and TLR3 in the DF-1 Chicken Fibroblast Cell Line Impairs Innate Immune Response Against RNA Ligands

(2020) Su Bin Lee et al.   Frontiers in Immunology

Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection

(2020) Heinz Fischer et al.   Frontiers in Immunology

Positive selection and convergent evolution shape molecular phenotypic traits of innate immunity receptors in tits (Paridae)

(2020) Martin Těšický et al.   MOLECULAR ECOLOGY

Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5

(2019) Morgan Brisse et al.   Frontiers in Immunology

The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans

(2019) Karim Majzoub et al.   Viruses-Basel

Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I

(2019) Ling Xu et al.   Journal of Genetics and Genomics

Toll-Like Receptor Evolution in Birds: Gene Duplication, Pseudogenization, and Diversifying Selection

(2018) Hana Velová et al.   MOLECULAR BIOLOGY AND EVOLUTION

Functional Evolution of Avian RIG-I-Like Receptors

(2018) Wanjing Zheng et al.   Genes

Evolution by gene loss

(2016) Ricard Albalat et al.   NATURE REVIEWS GENETICS

Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew

(2016) Ling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing

(2016) Matae Ahn et al.   Scientific Reports

Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales

(2015) Benjamin A. Braun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Distribution and Conservation of Evolutionary Distinctness in Birds

(2014) Walter Jetz et al.   CURRENT BIOLOGY

First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds

(2014) Hana Bainová et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

MDA5 and LGP2: Accomplices and Antagonists of Antiviral Signal Transduction

(2014) K. R. Rodriguez et al.   JOURNAL OF VIROLOGY

RELAX: Detecting Relaxed Selection in a Phylogenetic Framework

(2014) Joel O. Wertheim et al.   MOLECULAR BIOLOGY AND EVOLUTION

A series of PDB-related databanks for everyday needs

(2014) Wouter G. Touw et al.   NUCLEIC ACIDS RESEARCH

Distance-dependent hydrophobic–hydrophobic contacts in protein folding simulations

(2014) Angelo Onofrio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Defense genes missing from the flight division

(2013) Katharine E. Magor et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Chicken MDA5 Senses Short Double-Stranded RNA with Implications for Antiviral Response against Avian Influenza Viruses in Chicken

(2013) Tsuyoshi Hayashi et al.   Journal of Innate Immunity

RIG-I-Like Receptors Evolved Adaptively in Mammals, with Parallel Evolution at LGP2 and RIG-I

(2013) Rachele Cagliani et al.   JOURNAL OF MOLECULAR BIOLOGY

Positive Evolutionary Selection On the RIG-I-Like Receptor Genes in Mammals

(2013) Ana Lemos de Matos et al.   PLoS One

Rules of Engagement: Molecular Insights from Host-Virus Arms Races

(2012) Matthew D. Daugherty et al.   Annual Review of Genetics

Identification of avian RIG-I responsive genes during influenza infection

(2012) Megan R.W. Barber et al.   MOLECULAR IMMUNOLOGY

The global diversity of birds in space and time

(2012) W. Jetz et al.   NATURE

Detecting Individual Sites Subject to Episodic Diversifying Selection

(2012) Ben Murrell et al.   PLoS Genetics

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

Characterization of Chicken Mda5 Activity: Regulation of IFN-  in the Absence of RIG-I Functionality

(2011) A. J. Karpala et al.   JOURNAL OF IMMUNOLOGY

Adenovirus Virus-Associated RNAs Induce Type I Interferon Expression through a RIG-I-Mediated Pathway

(2011) T. Minamitani et al.   JOURNAL OF VIROLOGY

Association of RIG-I with innate immunity of ducks to influenza

(2010) M. R. W. Barber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salt bridges: Geometrically specific, designable interactions

(2010) Jason E. Donald et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

DOG 1.0: illustrator of protein domain structures

(2009) Jian Ren et al.   CELL RESEARCH