Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis

p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages

(2014) Julie M. Lowe et al.   CANCER RESEARCH

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Macrophage uptake and accumulation of folates are polarization-dependent in vitro and in vivo and are regulated by activin A

(2014) Rafael Samaniego et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile

(2014) Blanca Soler Palacios et al.   JOURNAL OF PATHOLOGY

Standing the test of time: targeting thymidylate biosynthesis in cancer therapy

(2014) Peter M. Wilson et al.   Nature Reviews Clinical Oncology

Role of Key TYMS Polymorphisms on Methotrexate Therapeutic Outcome in Portuguese Rheumatoid Arthritis Patients

(2014) Aurea Lima et al.   PLoS One

Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937

(2014) Nancy J Olsen et al.   ARTHRITIS RESEARCH & THERAPY

Methotrexate Normalizes Up-Regulated Folate Pathway Genes in Rheumatoid Arthritis

(2013) Marjolein Blits et al.   ARTHRITIS AND RHEUMATISM

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

(2013) Giovanni Germano et al.   CANCER CELL

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Methotrexate Chemotherapy Promotes Osteoclast Formation in the Long Bone of Rats via Increased Pro-Inflammatory Cytokines and Enhanced NF-κB Activation

(2012) Tristan J. King et al.   AMERICAN JOURNAL OF PATHOLOGY

Orchestration of Metabolism by Macrophages

(2012) Subhra K. Biswas et al.   Cell Metabolism

Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance

(2012) Nitzan Gonen et al.   DRUG RESISTANCE UPDATES

Association of the TYMS 3G/3G genotype with poor response and GGH 354GG genotype with the bone marrow toxicity of the methotrexate in RA patients

(2012) Biljana Jekic et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The secret ally: immunostimulation by anticancer drugs

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Methotrexate increases expression of cell cycle checkpoint genes via JNK activation

(2011) Charles F. Spurlock et al.   ARTHRITIS AND RHEUMATISM

Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers

(2011) E. Sierra-Filardi et al.   BLOOD

Macrophages at the Fetal-Maternal Interface Express Markers of Alternative Activation and Are Induced by M-CSF and IL-10

(2011) J. Svensson et al.   JOURNAL OF IMMUNOLOGY

An update on methotrexate

(2010) Juergen Braun et al.   CURRENT OPINION IN RHEUMATOLOGY

Methotrexate—how does it really work?

(2010) Edwin S. L. Chan et al.   Nature Reviews Rheumatology

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

(2010) Christian Steidl et al.   NEW ENGLAND JOURNAL OF MEDICINE

The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases

(2009) John A. Hamilton et al.   ARTHRITIS AND RHEUMATISM

Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice

(2009) Denis Bedoret et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations

(2009) Ramon Kaneno et al.   Journal of Translational Medicine

Thymidylate synthase gene variations: predictive and prognostic markers

(2009) G. Lurje et al.   MOLECULAR CANCER THERAPEUTICS

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative

(2008) K Visser et al.   ANNALS OF THE RHEUMATIC DISEASES

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In Vivo Response to Methotrexate Forecasts Outcome of Acute Lymphoblastic Leukemia and Has a Distinct Gene Expression Profile

(2008) Michael J Sorich et al.   PLOS MEDICINE