A Novel GMP Protocol to Produce High-Quality Treg Cells From the Pediatric Thymic Tissue to Be Employed as Cellular Therapy

Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders – Advances and challenges

(2022) Tapas Kumar Goswami et al.   Human Vaccines & Immunotherapeutics

Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation

(2021) Jacobo López-Abente et al.   Scientific Reports

Adoptive Transfer of Regulatory Immune Cells in Organ Transplantation

(2021) Nathaniel Oberholtzer et al.   Frontiers in Immunology

Isolation and expansion of thymus‐derived regulatory T cells for use in paediatric heart transplant patients

(2021) Marco Romano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T Cells and Inflammatory Mediators in Autoimmune Disease

(2021) Victoire Gouirand et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China

(2020) Jin-jin Zhang et al.   ALLERGY

Regulatory T-cell therapy in Crohn’s disease: challenges and advances

(2020) Jennie N Clough et al.   GUT

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

(2020) Birgit Sawitzki et al.   LANCET

Clinical-Grade Expanded Regulatory T Cells Are Enriched with Highly Suppressive Cells Producing IL-10, Granzyme B, and IL-35

(2020) Francesca Ulbar et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Immune dysregulation and Th2 polarization are associated with atopic dermatitis in heart-transplant children: A delicate balance between risk of rejection or atopic symptoms

(2019) Jacobo López-Abente et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Methods to manufacture regulatory T cells for cell therapy

(2019) Katherine N. MacDonald et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Epigenetic and transcriptional analysis supports human regulatory T cell commitment at the CD4+CD8+ thymocyte stage

(2019) Reetta Vanhanen et al.   CELLULAR IMMUNOLOGY

Cell banking for regulatory T cell-based therapy: strategies to overcome the impact of cryopreservation on the Treg viability and phenotype

(2018) Karolina Gołąb et al.   Oncotarget

Clinical Grade Regulatory CD4+ T Cells (Tregs): Moving Toward Cellular-Based Immunomodulatory Therapies

(2018) Richard Duggleby et al.   Frontiers in Immunology

Cytokine release syndrome

(2018) Alexander Shimabukuro-Vornhagen et al.   Journal for ImmunoTherapy of Cancer

OR42 Expanded thymic regulatory T cells (Tregs) have low class I HLA expression levels and are HLA-DR negative – Potential for ‘Off-The-Shelf’ Cellular Therapy?

(2017) Esme Dijke et al.   HUMAN IMMUNOLOGY

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells

(2015) I. E. Dijke et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

(2015) C. G. Brunstein et al.   BLOOD

Developing in vitro expanded CD45RA+regulatory T cells as an adoptive cell therapy for Crohn's disease

(2015) James B Canavan et al.   GUT

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

T regulatory cell separation for clinical application

(2012) Mauro Di Ianni et al.   TRANSFUSION AND APHERESIS SCIENCE

Immunoselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantation

(2011) Mauro Di Ianni et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Regulatory T cells in stem cell transplantation: strategies and first clinical experiences

(2011) Matthias Edinger et al.   CURRENT OPINION IN IMMUNOLOGY

Differentiation of human thymic regulatory T cells at the double positive stage

(2011) Helena Nunes-Cabaço et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Suppression assays with human T regulatory cells: A technical guide

(2011) Alicia N. McMurchy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CXCR3 in T cell function

(2011) Joanna R. Groom et al.   EXPERIMENTAL CELL RESEARCH

Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development

(2010) E. Martin-Gayo et al.   BLOOD

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Human regulatory T cells in autoimmune diseases

(2010) Gregory L Cvetanovich et al.   CURRENT OPINION IN IMMUNOLOGY

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Loss of FOXP3 expression in natural human CD4+CD25+regulatory T cells upon repetitivein vitrostimulation

(2009) Petra Hoffmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

(2009) James L. Riley et al.   IMMUNITY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Comparative Study of Regulatory T Cell Function of HumanCD25+CD4+T Cells from Thymocytes, Cord Blood, and Adult Peripheral Blood

(2008) Wakae Fujimaki et al.   Clinical & Developmental Immunology

Mechanisms of regulatory T-cell suppression – a diverse arsenal for a moving target

(2008) Dorothy K. Sojka et al.   IMMUNOLOGY