A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors

H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2

(2021) Yaling Li et al.   TECHNOLOGY AND HEALTH CARE

Experimental liver models: from cell culture techniques to microfluidic organs‐on‐chip

(2021) Michela Anna Polidoro et al.   LIVER INTERNATIONAL

Proton Pump Inhibitors Directly Block hERG-Potassium Channel and Independently Increase the Risk of QTc Prolongation in a Large Cohort of US Veterans

(2021) Pietro Enea Lazzerini et al.   Circulation-Arrhythmia and Electrophysiology

In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

(2021) Fredrik Kullenberg et al.   Cells

Inhibition of human CYP1 enzymes by a classical inhibitor α‐naphthoflavone and a novel inhibitor N‐(3, 5‐ dichlorophenyl)cyclopropanecarboxamide ‐ an in vitro and in silico study

(2020) Risto Olavi Juvonen et al.   Chemical Biology & Drug Design

New molecular and biochemical insights of doxorubicin-induced hepatotoxicity

(2020) Pureti Lakshmi Prasanna et al.   LIFE SCIENCES

Preventing and Treating Anthracycline Cardiotoxicity: New Insights

(2020) Konrad Teodor Sawicki et al.   Annual Review of Pharmacology and Toxicology

Doxorubicin-loaded pH-sensitive micelles: A promising alternative to enhance antitumor activity and reduce toxicity

(2020) Carolina Henriques Cavalcante et al.   BIOMEDICINE & PHARMACOTHERAPY

Safety screening in early drug discovery: An optimized assay panel

(2019) Stefanie Bendels et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts

(2019) Elena Gazzano et al.   CANCER LETTERS

The In Silico Drug Discovery Toolbox: Applications in Lead Discovery and Optimization

(2019) Agostino Bruno et al.   CURRENT MEDICINAL CHEMISTRY

The multi-factorial nature of clinical multidrug resistance in cancer

(2019) Yehuda G. Assaraf et al.   DRUG RESISTANCE UPDATES

Computational/in silico methods in drug target and lead prediction

(2019) Francis E Agamah et al.   BRIEFINGS IN BIOINFORMATICS

New NO- and H2S-releasing doxorubicins as targeted therapy against chemoresistance in castration-resistant prostate cancer: in vitro and in vivo evaluations

(2018) Elisabetta Bigagli et al.   INVESTIGATIONAL NEW DRUGS

Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma

(2018) Ilaria Buondonno et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors

(2016) Birgit Viira et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Using zebrafish in systems toxicology for developmental toxicity testing

(2016) Yuhei Nishimura et al.   CONGENITAL ANOMALIES

Human cytosolic sulfotransferase SULT1C4 mediates the sulfation of doxorubicin and epirubicin

(2016) Lijun Luo et al.   Drug Metabolism and Pharmacokinetics

H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance

(2016) Konstantin Chegaev et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arginase Flavonoid Anti-Leishmanial in Silico Inhibitors Flagged against Anti-Targets

(2016) Sanja Glisic et al.   MOLECULES

Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing

(2016) Hansaim Lim et al.   PLoS Computational Biology

Using zebrafish in systems toxicology for developmental toxicity testing

(2016) Yuhei Nishimura et al.   CONGENITAL ANOMALIES

Toxicology Strategies for Drug Discovery: Present and Future

(2015) Eric A. G. Blomme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Synthesis and identification of unprecedented selective inhibitors of CK1ε

(2015) Gastón Silveira-Dorta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cardiotoxicity evaluation of anthracyclines in zebrafish (Danio rerio)

(2014) Ying Han et al.   JOURNAL OF APPLIED TOXICOLOGY

Effects of rhamnocitrin 4-β-D-galactopyranoside, isolated from Astragalus hamosus on toxicity models in vitro

(2014) Ilina Krasteva et al.   Pharmacognosy Magazine

Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos

(2013) Stephan Fischer et al.   BMC BIOLOGY

Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities

(2013) Andreas Sutter et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Identification and Characterization of Reactive Metabolites in Natural Products-Driven Drug Discovery

(2012) Nicholas M. Njuguna et al.   JOURNAL OF NATURAL PRODUCTS

hERG K+ Channels: Structure, Function, and Clinical Significance

(2012) Jamie I. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

On-target and Off-target-based Toxicologic Effects

(2012) Daniel G. Rudmann   TOXICOLOGIC PATHOLOGY

Assessing confidence in predictions made by knowledge-based systems

(2012) Philip N. Judson et al.   Toxicology Research

In vitro models for liver toxicity testing

(2012) Valerie Y. Soldatow et al.   Toxicology Research

Dual inhibitors of P-glycoprotein and tumor cell growth: (Re)discovering thioxanthones

(2011) Andreia Palmeira et al.   BIOCHEMICAL PHARMACOLOGY

An integrated microfluidic array system for evaluating toxicity and teratogenicity of drugs on embryonic zebrafish developmental dynamics

(2011) Fan Yang et al.   Biomicrofluidics

Reducing QT liability and proarrhythmic risk in drug discovery and development

(2010) Jean-Pierre Valentin   BRITISH JOURNAL OF PHARMACOLOGY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Docking and Virtual Screening Using Distributed Grid Technology

(2009) Alfonso T. García-Sosa et al.   Quantitative structure-activity relationships & combinatorial science