期刊
CONGENITAL ANOMALIES
卷 56, 期 1, 页码 18-27出版社
WILEY
DOI: 10.1111/cga.12142
关键词
chemical exposure; developmental toxicity; housing; systems toxicology; zebrafish
类别
资金
- Japan Society for the Promotion of Science KAKENHI [25670127, 15K15051, 24510069]
- JST A-STEP [AS262Z00004Q]
- Long-Range Research Initiative of the Japan Chemical Industrial Association [13_PT01-01]
With the high cost and the long-term assessment of developmental toxicity testing in mammals, the vertebrate zebrafish has become a useful alternative model organism for high-throughput developmental toxicity testing. Zebrafish is also very favorable for the 3R perspective in toxicology; however, the methodologies used by research groups vary greatly, posing considerable challenges to integrative analysis. In this review, we discuss zebrafish developmental toxicity testing, focusing on the methods of chemical exposure, the assessment of morphological abnormalities, housing conditions and their effects on the production of healthy embryos, and future directions. Zebrafish as a systems toxicology model has the potential to elucidate developmental toxicity pathways, and to provide a sound basis for human health risk assessments.
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