An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex

Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

(2016) Ineke Brouwer et al.   NATURE

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

(2016) Gabrielle J. Grundy et al.   Nature Communications

Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains

(2015) Amy L. Cherry et al.   DNA REPAIR

Functional advantages of dynamic protein disorder

(2015) Rebecca B. Berlow et al.   FEBS LETTERS

Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining

(2015) Wenxia Jiang et al.   MOLECULAR CELL

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair

(2015) Dylan A. Reid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into NHEJ: Building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time

(2014) Gareth J. Williams et al.   DNA REPAIR

Super-Resolution in Solution X-Ray Scattering and Its Applications to Structural Systems Biology

(2013) Robert P. Rambo et al.   Annual Review of Biophysics

The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response

(2013) M. Li et al.   GENES & DEVELOPMENT

Detection and Repair of Ionizing Radiation-Induced DNA Double Strand Breaks: New Developments in Nonhomologous End Joining

(2013) Chen Wang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source

(2013) Scott Classen et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Identification and Functional Characterization of a Ku-binding Motif in Aprataxin Polynucleotide Kinase/Phosphatase-like Factor (APLF)

(2013) Purnata Shirodkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A noncatalytic function of the ligation complex during nonhomologous end joining

(2013) Jessica Cottarel et al.   JOURNAL OF CELL BIOLOGY

Accurate assessment of mass, models and resolution by small-angle scattering

(2013) Robert P. Rambo et al.   NATURE

The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair

(2013) Amanda L. Fenton et al.   NUCLEIC ACIDS RESEARCH

Non-homologous end-joining partners in a helical dance: structural studies of XLF–XRCC4 interactions

(2012) Qian Wu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

APLF promotes the assembly and activity of non-homologous end joining protein complexes

(2012) Gabrielle J Grundy et al.   EMBO JOURNAL

A human XRCC4–XLF complex bridges DNA

(2012) Sara N. Andres et al.   NUCLEIC ACIDS RESEARCH

Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV

(2012) Takashi Ochi et al.   STRUCTURE

Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law

(2011) Robert P. Rambo et al.   BIOPOLYMERS

Live cell imaging of XLF and XRCC4 reveals a novel view of protein assembly in the non-homologous end-joining pathway

(2011) Ken-ichi Yano et al.   CELL CYCLE

Electron microscopy visualization of DNA–protein complexes formed by Ku and DNA ligase IV

(2011) Patricia Grob et al.   DNA REPAIR

Polynucleotide Kinase and Aprataxin-like Forkhead-associated Protein (PALF) Acts as Both a Single-stranded DNA Endonuclease and a Single-Stranded DNA 3′ Exonuclease and Can Participate in DNA End Joining in a Biochemical System

(2011) Sicong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

(2011) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modeling non-homologous end joining

(2011) Yongfeng Li et al.   JOURNAL OF THEORETICAL BIOLOGY

DNA Repair Factor APLF Is a Histone Chaperone

(2011) Pawan Vinod Mehrotra et al.   MOLECULAR CELL

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

(2010) Gareth J. Williams et al.   DNA REPAIR

Yeast Nej1 Is a Key Participant in the Initial End Binding and Final Ligation Steps of Nonhomologous End Joining

(2010) Xi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase

(2010) Rajam S. Mani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose)

(2010) Sebastian Eustermann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response

(2010) G.-Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XLF Regulates Filament Architecture of the XRCC4·Ligase IV Complex

(2010) Michal Hammel et al.   STRUCTURE

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

(2009) Brandi L. Mahaney et al.   BIOCHEMICAL JOURNAL

Structure and flexibility within proteins as identified through small angle X-ray scattering

(2009) M. Pelikan et al.   GENERAL PHYSIOLOGY AND BIOPHYSICS

DAMMIF, a program for rapidab-initioshape determination in small-angle scattering

(2009) Daniel Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

(2009) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4

(2009) P.-Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

(2009) Bancinyane L. Sibanda et al.   NATURE

Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

(2009) Greg L Hura et al.   NATURE METHODS

DNA-Dependent Conformational Changes in the Ku Heterodimer†

(2008) Jason A. Lehman et al.   BIOCHEMISTRY

APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation

(2008) Chloe J. Macrae et al.   DNA REPAIR

Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining

(2008) J. Gu et al.   GENES & DEVELOPMENT

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

(2008) Ivan Ahel et al.   NATURE

XLF-Cernunnos promotes DNA ligase IV–XRCC4 re-adenylation following ligation

(2008) Enriqueta Riballo et al.   NUCLEIC ACIDS RESEARCH