Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome

A Rapid and Versatile Method for Generating Proteins with Defined Ubiquitin Chains

(2016) Kirby Martinez-Fonts et al.   BIOCHEMISTRY

Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome

(2016) Y. Shi et al.   SCIENCE

Gates, Channels, and Switches: Elements of the Proteasome Machine

(2016) Daniel Finley et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system

(2016) Mainak Guharoy et al.   Nature Communications

An Inducible System for Rapid Degradation of Specific Cellular Proteins Using Proteasome Adaptors

(2016) Shameika R. Wilmington et al.   PLoS One

Evolution of Proteasome Regulators in Eukaryotes

(2015) Philippe Fort et al.   Genome Biology and Evolution

Sequence composition of disordered regions fine-tunes protein half-life

(2015) Susan Fishbain et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of antizyme-mediated regulation of polyamine homeostasis

(2015) Hsiang-Yi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specificity of the anaphase-promoting complex: A single-molecule study

(2015) Y. Lu et al.   SCIENCE

Substrate degradation by the proteasome: A single-molecule kinetic analysis

(2015) Y. Lu et al.   SCIENCE

Sequence composition of disordered regions fine-tunes protein half-life

(2015) Susan Fishbain et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dissection of Axial-Pore Loop Function during Unfolding and Translocation by a AAA+ Proteolytic Machine

(2015) Ohad Iosefson et al.   Cell Reports

Ubiquitination in disease pathogenesis and treatment

(2014) Doris Popovic et al.   NATURE MEDICINE

The DynaMine webserver: predicting protein dynamics from sequence

(2014) Elisa Cilia et al.   NUCLEIC ACIDS RESEARCH

Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome

(2014) P. Unverdorben et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution

(2014) Robin van der Lee et al.   Cell Reports

Ubiquitin-independent proteasomal degradation

(2013) Jenny Erales et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

(2013) James A Nathan et al.   EMBO JOURNAL

Expanded Polyglutamine-containing N-terminal Huntingtin Fragments Are Entirely Degraded by Mammalian Proteasomes

(2013) Katrin Juenemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase

(2013) Robyn Beckwith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational switching of the 26S proteasome enables substrate degradation

(2013) Mary E Matyskiela et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the 26S proteasome with ATP- S bound provides insights into the mechanism of nucleotide-dependent substrate translocation

(2013) P. Sledz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From protein sequence to dynamics and disorder with DynaMine

(2013) Elisa Cilia et al.   Nature Communications

Sequence- and Species-Dependence of Proteasomal Processivity

(2012) Daniel A. Kraut et al.   ACS Chemical Biology

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks

(2012) Marija Buljan et al.   MOLECULAR CELL

Complete subunit architecture of the proteasome regulatory particle

(2012) Gabriel C. Lander et al.   NATURE

Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters

(2012) Eilon Sharon et al.   NATURE BIOTECHNOLOGY

APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1

(2012) Nevena V. Dimova et al.   NATURE CELL BIOLOGY

Linear motifs confer functional diversity onto splice variants

(2012) Robert J. Weatheritt et al.   NUCLEIC ACIDS RESEARCH

Identification of the Cdc48bullet20S Proteasome as an Ancient AAA+ Proteolytic Machine

(2012) D. Barthelme et al.   SCIENCE

Proteasomal Degradation from Internal Sites Favors Partial ProteolysisviaRemote Domain Stabilization

(2011) Daniel A. Kraut et al.   ACS Chemical Biology

ClpXP, an ATP-powered unfolding and protein-degradation machine

(2011) Tania A. Baker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of Ubiquitin Chain Initiation to Control the Timing of Substrate Degradation

(2011) Adam Williamson et al.   MOLECULAR CELL

Cdc48/p97 Mediates UV-Dependent Turnover of RNA Pol II

(2011) Rati Verma et al.   MOLECULAR CELL

A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction

(2011) Malavika Raman et al.   MOLECULAR CELL

Autoantigen discovery with a synthetic human peptidome

(2011) H Benjamin Larman et al.   NATURE BIOTECHNOLOGY

Defining the geometry of the two-component proteasome degron

(2011) Tomonao Inobe et al.   Nature Chemical Biology

Rad23 escapes degradation because it lacks a proteasome initiation region

(2011) Susan Fishbain et al.   Nature Communications

Combined chemical and genetic approach to inhibit proteolysis by the proteasome

(2010) Galen A. Collins et al.   YEAST

Characterization of different promoters for designing a new expression vector in Saccharomyces cerevisiae

(2010) Siavash Partow et al.   YEAST

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

(2009) Yasushi Saeki et al.   EMBO JOURNAL

Degradation of Some Polyubiquitinated Proteins Requires an Intrinsic Proteasomal Binding Element in the Substrates

(2009) Minglian Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lysine 48 and Lysine 63 Ubiquitin Conjugates Are Processed Differently by the 26 S Proteasome

(2009) Andrew D. Jacobson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conserved Unfoldase Activity for the p97 AAA-ATPase in Proteasomal Degradation

(2009) Anne Beskow et al.   JOURNAL OF MOLECULAR BIOLOGY

Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination Is Sufficient for Proteasomal Processing of the p105 NF-κB Precursor

(2009) Yelena Kravtsova-Ivantsiv et al.   MOLECULAR CELL

Mechanism of Substrate Unfolding and Translocation by the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschii

(2009) Fan Zhang et al.   MOLECULAR CELL

Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

(2009) Janine Kirstein et al.   NATURE REVIEWS MICROBIOLOGY

Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation

(2009) N. Shabek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paddling mechanism for the substrate translocation by AAA+ motor revealed by multiscale molecular simulations

(2009) N. Koga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse Pore Loops of the AAA+ ClpX Machine Mediate Unassisted and Adaptor-Dependent Recognition of ssrA-Tagged Substrates

(2008) Andreas Martin et al.   MOLECULAR CELL

Proteasome subunit Rpn13 is a novel ubiquitin receptor

(2008) Koraljka Husnjak et al.   NATURE

Substrate selection by the proteasome during degradation of protein complexes

(2008) Sumit Prakash et al.   Nature Chemical Biology

A noncytotoxic DsRed variant for whole-cell labeling

(2008) Rita L Strack et al.   NATURE METHODS

Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding

(2008) Andreas Martin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Global Protein Stability Profiling in Mammalian Cells

(2008) H.-C. S. Yen et al.   SCIENCE