Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase

Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor

(2015) Thomas E. Wales et al.   BIOCHEMISTRY

Hepatitis C Virus Treatment: Is It Possible To Cure All Hepatitis C Virus Patients?

(2015) Andrew J. Muir et al.   Clinical Gastroenterology and Hepatology

How amide hydrogens exchange in native proteins

(2015) Filip Persson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for RNA replication by the hepatitis C virus polymerase

(2015) T. C. Appleby et al.   SCIENCE

Molecular modeling and residue interaction network studies on the mechanism of binding and resistance of the HCV NS5B polymerase mutants to VX-222 and ANA598

(2014) Weiwei Xue et al.   ANTIVIRAL RESEARCH

Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation

(2014) Amy L. Cherry et al.   JOURNAL OF VIROLOGY

Structural and Regulatory Elements of HCV NS5B Polymerase – β-Loop and C-Terminal Tail – Are Required for Activity of Allosteric Thumb Site II Inhibitors

(2014) Sarah E. Boyce et al.   PLoS One

The Increasing Burden of Mortality From Viral Hepatitis in the United States Between 1999 and 2007

(2013) Kathleen N. Ly et al.   ANNALS OF INTERNAL MEDICINE

Resolution of the interaction mechanisms and characteristics of non-nucleoside inhibitors of hepatitis C virus polymerase

(2013) Johan Winquist et al.   ANTIVIRAL RESEARCH

Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection

(2013) Scott E. Lazerwith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of Overlapped and Noisy Hydrogen/Deuterium Exchange Mass Spectra

(2013) Miklos Guttman et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase

(2013) Brittny C. Davis et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors

(2012) Eda Canales et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex

(2012) Zhinan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Evidence for a Dynamically Driven T Cell Signaling Mechanism

(2012) W. F. Hawse et al.   JOURNAL OF IMMUNOLOGY

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

(2012) R. T. Mosley et al.   JOURNAL OF VIROLOGY

Allosteric Suppression of HIV-1 Reverse Transcriptase Structural Dynamics upon Inhibitor Binding

(2011) James M. Seckler et al.   BIOPHYSICAL JOURNAL

An Objective Assessment of Conformational Variability in Complexes of Hepatitis C Virus Polymerase with Non-Nucleoside Inhibitors

(2011) Célia Caillet-Saguy et al.   JOURNAL OF MOLECULAR BIOLOGY

Ligand-Dependent Perturbation of the Conformational Ensemble for the GPCR β2 Adrenergic Receptor Revealed by HDX

(2011) Graham M. West et al.   STRUCTURE

Ligand-induced changes in hepatitis C virus NS5B polymerase structure

(2010) Karen Rigat et al.   ANTIVIRAL RESEARCH

Further Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis

(2010) Déborah Harrus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies

(2010) Damian Houde et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Allosteric inhibition of complement function by a staphylococcal immune evasion protein

(2010) Hui Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen/Deuterium Exchange Reveals Distinct Agonist/Partial Agonist Receptor Dynamics within Vitamin D Receptor/Retinoid X Receptor Heterodimer

(2010) Jun Zhang et al.   STRUCTURE

Solution Structural Dynamics of HIV-1 Reverse Transcriptase Heterodimer

(2009) James M. Seckler et al.   BIOCHEMISTRY

Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

(2009) Julie Qi Hang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor

(2009) Hui Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase

(2008) Sreedhar Chinnaswamy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY