期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 5, 页码 1255-1258出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm8014537
关键词
-
The HCV RNA-dependent RNA polymerase has emerged as one of the key targets for novel anti-HCV therapy development. Herein. we report the optimization of the dihydropyrone series inhibitors to improve compound aqueous solubility and reduce CYP2D6 inhibition. which led to the discovery of compound 24 (PF-00868554). Compound 24 is a potent and selective HCV polymerase inhibitor with a favorable pharmacokinetic profile and has recently entered a phase If clinical evaluation in patients with genotype I HCV.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据