Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway

Rare coding variants in ten genes confer substantial risk for schizophrenia

(2022) Tarjinder Singh et al.   NATURE

Biochemical evidence accumulates across neurons to drive a network-level eruption

(2021) Stephen C. Thornquist et al.   MOLECULAR CELL

Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly?

(2021) Angel Carvajal-Oliveros et al.   Frontiers in Behavioral Neuroscience

Genetic architecture of schizophrenia: a review of major advancements

(2021) Sophie E. Legge et al.   PSYCHOLOGICAL MEDICINE

Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks

(2021) Britt Mossink et al.   MOLECULAR PSYCHIATRY

Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1a+/− Mice

(2020) Jordan P. Hamm et al.   BIOLOGICAL PSYCHIATRY

Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome

(2020) Joost Kummeling et al.   MOLECULAR PSYCHIATRY

Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels

(2020) Jennifer van der Horst et al.   Frontiers in Physiology

Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities

(2020) Kenichiro Nagahama et al.   Cell Reports

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

(2020) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Determining cell type abundance and expression from bulk tissues with digital cytometry

(2019) Aaron M. Newman et al.   NATURE BIOTECHNOLOGY

Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection

(2019) Antonia Alexandra Evripioti et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

De Novo and Inherited SETD1A Variants in Early-onset Epilepsy

(2019) Xiuya Yu et al.   Neuroscience Bulletin

Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice

(2019) Jun Mukai et al.   NEURON

Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling

(2019) Monica Frega et al.   Nature Communications

Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register

(2018) Rikke Hilker et al.   BIOLOGICAL PSYCHIATRY

A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development

(2018) Else Eising et al.   MOLECULAR PSYCHIATRY

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

Mixed-species RNA-seq for elucidation of non-cell-autonomous control of gene transcription

(2018) Jing Qiu et al.   Nature Protocols

cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia

(2018) Haitao Wang et al.   Frontiers in Molecular Neuroscience

Male-specific cAMP signaling in the hippocampus controls spatial memory deficits in a mouse model of autism and intellectual disability

(2018) Marta Zamarbide et al.   BIOLOGICAL PSYCHIATRY

Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3

(2017) Nicolas Gutierrez-Castellanos et al.   NEURON

Different phosphodiesterases (PDEs) regulate distinct phosphoproteomes during cAMP signaling

(2017) Paul M. Epstein   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic plasticity through activation of GluA3-containing AMPA-receptors

(2017) Maria C Renner et al.   eLife

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

(2016) Mohammad A. Mandegar et al.   Cell Stem Cell

Role of astrocyte-synapse interactions in CNS disorders

(2016) Elena Blanco-Suárez et al.   JOURNAL OF PHYSIOLOGY-LONDON

Schizophrenia

(2016) Michael J Owen et al.   LANCET

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

(2016) Tarjinder Singh et al.   NATURE NEUROSCIENCE

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

(2016) Remco V. Klaassen et al.   Nature Communications

Slitrk Missense Mutations Associated with Neuropsychiatric Disorders Distinctively Impair Slitrk Trafficking and Synapse Formation

(2016) Hyeyeon Kang et al.   Frontiers in Molecular Neuroscience

Forskolin Suppresses Delayed-Rectifier K+ Currents and Enhances Spike Frequency-Dependent Adaptation of Sympathetic Neurons

(2015) Luis I. Angel-Chavez et al.   PLoS One

PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury

(2015) Juhyun Song et al.   NEURAL PLASTICITY

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Isolation of single-base genome-edited human iPS cells without antibiotic selection

(2014) Yuichiro Miyaoka et al.   NATURE METHODS

Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate Susceptibility Gene

(2014) Atsushi Takata et al.   NEURON

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophrenia

(2013) Xinguo Ren et al.   JOURNAL OF AFFECTIVE DISORDERS

Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases

(2013) Y. S. Yim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

The Cyclic AMP Pathway

(2012) P. Sassone-Corsi   Cold Spring Harbor Perspectives in Biology

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

(2011) Thérèse Keravis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms

(2011) Guoqiang Wan et al.   CELLULAR SIGNALLING

Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia

(2011) Vladimir Vacic et al.   NATURE

Abnormal Activity of the MAPK- and cAMP-Associated Signaling Pathways in Frontal Cortical Areas in Postmortem Brain in Schizophrenia

(2011) Adam J Funk et al.   NEUROPSYCHOPHARMACOLOGY

Abnormal neural oscillations and synchrony in schizophrenia

(2010) Peter J. Uhlhaas et al.   NATURE REVIEWS NEUROSCIENCE

Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia

(2009) Kevin M Spencer et al.   BMC NEUROSCIENCE

Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling

(2009) Seung Namkoong et al.   CELLULAR SIGNALLING

Increased cAMP Levels Modulate Transforming Growth Factor-β/Smad-induced Expression of Extracellular Matrix Components and Other Key Fibroblast Effector Functions

(2009) Meinhard Schiller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic overlap between autism, schizophrenia and bipolar disorder

(2009) Liam S Carroll et al.   Genome Medicine

An Odor-Specific Threshold Deficit Implicates Abnormal Intracellular Cyclic AMP Signaling in Schizophrenia

(2008) Bruce I. Turetsky et al.   AMERICAN JOURNAL OF PSYCHIATRY

cAMP promotes neurite outgrowth and extension through protein kinase A but independently of Erk activation in cultured rat motoneurons

(2008) C. Aglah et al.   NEUROPHARMACOLOGY

The cyclic AMP phenotype of fragile X and autism

(2008) D KELLEY et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Pharmacological PKA Inhibition: All May Not Be What It Seems

(2008) A. J. Murray   Science Signaling