期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 32, 期 8, 页码 1533-1543出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2008.06.005
关键词
Autism; Fragile X; Cyclic AMP; cAMP; Signal transduction; FMRP; FMR1
资金
- NICHD NIH HHS [P30 HD003352-42, P30 HD003352] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008692] Funding Source: Medline
- NIMH NIH HHS [R01 MH067774] Funding Source: Medline
Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism. (c) 2008 Elsevier Ltd. All rights reserved
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