Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy

How the Mitoprotein-Induced Stress Response Safeguards the Cytosol: A Unified View

(2020) Felix Boos et al.   TRENDS IN CELL BIOLOGY

Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy

(2020) Eija Pirinen et al.   Cell Metabolism

Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations

(2020) Yi-Ting Liu et al.   HUMAN MOLECULAR GENETICS

NRF2, a Transcription Factor for Stress Response and Beyond

(2020) Feng He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Folding the Mitochondrial UPR into the Integrated Stress Response

(2020) Nadine S. Anderson et al.   TRENDS IN CELL BIOLOGY

Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2020) June-Wha Rhee et al.   Cell Reports

Mitochondrial Protein Quality Control Mechanisms

(2020) Pooja Jadiya et al.   Genes

Oxidative Stress and Antioxidant Treatments in Cardiovascular Diseases

(2020) Wenjun Wang et al.   Antioxidants

Transport of Proteins into Mitochondria

(2019) Katja G. Hansen et al.   PROTEIN JOURNAL

ALS/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response

(2019) Corey J. Anderson et al.   ACTA NEUROPATHOLOGICA

Mitochondrial defect in muscle precedes neuromuscular junction degeneration and motor neuron death in CHCHD10S59L/+ mouse

(2019) Emmanuelle C. Genin et al.   ACTA NEUROPATHOLOGICA

Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease

(2019) Vladan P. Bajic et al.   Oxidative Medicine and Cellular Longevity

Glucose Metabolism in Cardiac Hypertrophy and Heart Failure

(2019) Diem H. Tran et al.   Journal of the American Heart Association

Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions

(2019) Saara Forsström et al.   Cell Metabolism

Bilirubin acts as a multi-potent guardian of cardiovascular integrity: more than just a radical idea

(2018) Andrew Cameron Bulmer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations

(2018) Qiuying Chen et al.   Cell Metabolism

Structure and function of the Nppa–Nppb cluster locus during heart development and disease

(2018) Joyce Man et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

A Futile Battle? Protein Quality Control and the Stress of Aging

(2018) Ryo Higuchi-Sanabria et al.   DEVELOPMENTAL CELL

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Metabolic remodelling in heart failure

(2018) Edoardo Bertero et al.   Nature Reviews Cardiology

CoQ10 supplementation rescues nephrotic syndrome through normalization of H2S oxidation pathway

(2018) Giulio Kleiner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

(2018) Gloria M Palomo et al.   EMBO Molecular Medicine

Mechanisms of cardiac iron homeostasis and their importance to heart function

(2018) Samira Lakhal-Littleton   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dysfunction in pathophysiology of heart failure

(2018) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Atlas of Postnatal Mouse Heart Development

(2018) Virpi Talman et al.   Journal of the American Heart Association

In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions

(2017) S R Burstein et al.   HUMAN MOLECULAR GENETICS

MtDNA-maintenance defects: syndromes and genes

(2017) Carlo Viscomi et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals

(2017) Inge Kühl et al.   eLife

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

(2016) Joni Nikkanen et al.   Cell Metabolism

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureCLINICAL PERSPECTIVE

(2016) Haipeng Sun et al.   CIRCULATION

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i ‐AAA protease YME1L

(2016) Timothy Wai et al.   EMBO REPORTS

Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice

(2016) Suzanne M Cloonan et al.   NATURE MEDICINE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy

(2016) Shota Sasagawa et al.   Frontiers in Pharmacology

Mitochondrial Diseases and Cardiomyopathies

(2015) Catherine Brunel-Guitton et al.   CANADIAN JOURNAL OF CARDIOLOGY

NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NF B Signaling Pathways

(2015) Q. D. Zhao et al.   CIRCULATION

Iron-Induced Damage in Cardiomyopathy: Oxidative-Dependent and Independent Mechanisms

(2015) Elena Gammella et al.   Oxidative Medicine and Cellular Longevity

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Tissue-Specific Loss of DARS2 Activates Stress Responses Independently of Respiratory Chain Deficiency in the Heart

(2014) Sukru Anil Dogan et al.   Cell Metabolism

Mutation in the novel nuclear-encoded mitochondrial protein CHCHD10 in a family with autosomal dominant mitochondrial myopathy

(2014) Senda Ajroud-Driss et al.   NEUROGENETICS

Characterization of the Usage of the Serine Metabolic Network in Human Cancer

(2014) Mahya Mehrmohamadi et al.   Cell Reports

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell?

(2013) Jerome Piquereau et al.   Frontiers in Physiology

Mitochondrial quality control by the ubiquitin–proteasome system: Figure 1

(2012) Eric B. Taylor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cellular and mitochondrial iron homeostasis in vertebrates

(2012) Caiyong Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

From form to function: the role of Nox4 in the cardiovascular system

(2012) Feng Chen et al.   Frontiers in Physiology

Stomatin-Like Protein 2 Binds Cardiolipin and Regulates Mitochondrial Biogenesis and Function

(2011) D. A. Christie et al.   MOLECULAR AND CELLULAR BIOLOGY

Return to the fetal gene program

(2010) Heinrich Taegtmeyer et al.   Annals of the New York Academy of Sciences

Novel insights into the assembly and function of human nuclear-encoded cytochromecoxidase subunits 4, 5a, 6a, 7a and 7b

(2010) Daniela Fornuskova et al.   BIOCHEMICAL JOURNAL

Energy Metabolic Phenotype of the Cardiomyocyte During Development, Differentiation, and Postnatal Maturation

(2010) Gary D Lopaschuk et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA