ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer
出版年份 2022 全文链接
标题
ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer
作者
关键词
-
出版物
Nature Communications
Volume 13, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-04-27
DOI
10.1038/s41467-022-29963-5
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- The heterogeneity of prostate cancers lacking AR activity will require diverse treatment approaches
- (2021) Mark P Labrecque et al. ENDOCRINE-RELATED CANCER
- Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer
- (2021) Sylvan C. Baca et al. Nature Communications
- RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer
- (2021) Mark P. Labrecque et al. CANCER RESEARCH
- BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program
- (2021) Dae-Hwan Kim et al. CLINICAL CANCER RESEARCH
- An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer
- (2021) Alastair Davies et al. NATURE CELL BIOLOGY
- Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer
- (2021) Nicholas J. Brady et al. Nature Communications
- ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer
- (2021) Karine Pozo et al. iScience
- Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function
- (2021) Xiang Xu et al. CELL RESEARCH
- Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer
- (2021) Paloma Cejas et al. Nature Communications
- Small Cell Lung Carcinoma Subtypes Defined by ASCL1, NEUROD1, POU2F3 and YAP1: Comprehensive Immunohistochemical and Histopathologic Characterization
- (2020) Marina K. Baine et al. Journal of Thoracic Oncology
- Distinct transcriptional programs of SOX2 in different types of small cell lung cancers
- (2020) Yuki Tenjin et al. LABORATORY INVESTIGATION
- Evaluation of Intense Androgen Deprivation Before Prostatectomy: A Randomized Phase II Trial of Enzalutamide and Leuprolide With or Without Abiraterone
- (2019) Rana R. McKay et al. JOURNAL OF CLINICAL ONCOLOGY
- Genomic correlates of clinical outcome in advanced prostate cancer
- (2019) Wassim Abida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer
- (2019) Mark P. Labrecque et al. JOURNAL OF CLINICAL INVESTIGATION
- Clinical features of neuroendocrine prostate cancer
- (2019) Vincenza Conteduca et al. EUROPEAN JOURNAL OF CANCER
- TMPRSS2-ERG controls luminal epithelial lineage and antiandrogen sensitivity inPTENandTP53-mutated prostate cancer
- (2018) Alexandra M Blee et al. CLINICAL CANCER RESEARCH
- Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study
- (2018) Rahul Aggarwal et al. JOURNAL OF CLINICAL ONCOLOGY
- A phase 1b/2 study of CPI-1205, a small molecule inhibitor of EZH2, combined with enzalutamide (E) or abiraterone/prednisone (A/P) in patients with metastatic castration resistant prostate cancer (mCRPC).
- (2018) Mary-Ellen Taplin et al. JOURNAL OF CLINICAL ONCOLOGY
- Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function
- (2018) Lixin Wan et al. MOLECULAR CELL
- Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program
- (2018) Marisa Karow et al. NATURE NEUROSCIENCE
- Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer
- (2018) Maha Hussain et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers
- (2018) Bryan A. Smith et al. Cell Reports
- The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1
- (2018) Ashwin Narayanan et al. CELL DEATH AND DIFFERENTIATION
- Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage
- (2018) Jung Wook Park et al. SCIENCE
- A rapid and robust method for single cell chromatin accessibility profiling
- (2018) Xi Chen et al. Nature Communications
- Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance
- (2017) Sheng Yu Ku et al. SCIENCE
- Transdifferentiation as a Mechanism of Treatment Resistance in a Mouse Model of Castration-Resistant Prostate Cancer
- (2017) Min Zou et al. Cancer Discovery
- Androgen Receptor-Dependent and -Independent Mechanisms Involved in Prostate Cancer Therapy Resistance
- (2017) Daniel Crona et al. Cancers
- A new and improved algorithm for the quantification of chromatin condensation from microscopic data shows decreased chromatin condensation in regenerating axolotl limb cells
- (2017) Julian Sosnik et al. PLoS One
- Clinical variability and molecular heterogeneity in prostate cancer
- (2016) ChristopherE Barbieri et al. ASIAN JOURNAL OF ANDROLOGY
- Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
- (2016) Himisha Beltran et al. NATURE MEDICINE
- deepTools2: a next generation web server for deep-sequencing data analysis
- (2016) Fidel Ramírez et al. NUCLEIC ACIDS RESEARCH
- g:Profiler—a web server for functional interpretation of gene lists (2016 update)
- (2016) Jüri Reimand et al. NUCLEIC ACIDS RESEARCH
- Functionalizing Ascl1 with Novel Intracellular Protein Delivery Technology for Promoting Neuronal Differentiation of Human Induced Pluripotent Stem Cells
- (2016) Meghan Robinson et al. Stem Cell Reviews and Reports
- The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer
- (2016) Jennifer L. Bishop et al. Cancer Discovery
- ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs
- (2016) Mark D. Borromeo et al. Cell Reports
- Functionalizing Ascl1 with Novel Intracellular Protein Delivery Technology for Promoting Neuronal Differentiation of Human Induced Pluripotent Stem Cells
- (2016) Meghan Robinson et al. Stem Cell Reviews and Reports
- Advanced neuroendocrine prostate tumors regress to stemness
- (2015) Leigh Ellis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polycomb-mediated silencing in neuroendocrine prostate cancer
- (2015) Pier-Luc Clermont et al. Clinical Epigenetics
- Proposed Morphologic Classification of Prostate Cancer With Neuroendocrine Differentiation
- (2014) Jonathan I. Epstein et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers
- (2014) A. Augustyn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1
- (2014) Soham Chanda et al. Stem Cell Reports
- High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development
- (2013) D. Lin et al. CANCER RESEARCH
- Human ASH-1 Promotes Neuroendocrine Differentiation in Androgen Deprivation Conditions and Interferes With Androgen Responsiveness in Prostate Cancer Cells
- (2013) Ida Rapa et al. PROSTATE
- FOXO3 Shares Common Targets with ASCL1 Genome-wide and Inhibits ASCL1-Dependent Neurogenesis
- (2013) Ashley E. Webb et al. Cell Reports
- Rapid Generation of Functional Dopaminergic Neurons From Human Induced Pluripotent Stem Cells Through a Single-Step Procedure Using Cell Lineage Transcription Factors
- (2013) Ilda Theka et al. Stem Cells Translational Medicine
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
- (2012) Cole Trapnell et al. Nature Protocols
- Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy
- (2012) Howard I. Scher et al. NEW ENGLAND JOURNAL OF MEDICINE
- Abiraterone and Increased Survival in Metastatic Prostate Cancer
- (2011) Johann S. de Bono et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ascl1 (Mash1) Defines Cells with Long-Term Neurogenic Potential in Subgranular and Subventricular Zones in Adult Mouse Brain
- (2011) Euiseok J. Kim et al. PLoS One
- Understanding the Lethal Variant of Prostate Cancer: Power of Examining Extremes
- (2011) A. Aparicio et al. Cancer Discovery
- Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets
- (2011) H. Beltran et al. Cancer Discovery
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- Drug discovery targeting epigenetic codes: The great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis
- (2009) Motoko Unoki et al. BIOCHEMICAL PHARMACOLOGY
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- Fast and accurate short read alignment with Burrows-Wheeler transform
- (2009) H. Li et al. BIOINFORMATICS
- Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development
- (2009) Branden R. Nelson et al. DEVELOPMENTAL DYNAMICS
- Human ASH1 expression in prostate cancer with neuroendocrine differentiation
- (2008) Ida Rapa et al. MODERN PATHOLOGY
- Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
- (2008) Yutaka Kondo et al. NATURE GENETICS
- Longitudinal analysis of androgen deprivation of prostate cancer cells identifies pathways to androgen independence
- (2008) Jason M. D'Antonio et al. PROSTATE
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
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