Herpesvirus Replication Compartments: Dynamic Biomolecular Condensates?

Compartmentalization of telomeres through DNA-scaffolded phase separation

(2022) Amanda Jack et al.   DEVELOPMENTAL CELL

Analysis of Novel Drug-Resistant Human Cytomegalovirus DNA Polymerase Mutations Reveals the Role of a DNA-Binding Loop in Phosphonoformic Acid Resistance

(2022) Kye Ryeong Park et al.   Frontiers in Microbiology

Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication

(2022) Enrico Caragliano et al.   Cell Reports

Phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation

(2021) Olga Vladimirova et al.   PLoS Pathogens

The HSV-1 Transcription Factor ICP4 Confers Liquid-Like Properties to Viral Replication Compartments

(2021) Michael Seyffert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses

(2021) Florian Geiger et al.   EMBO JOURNAL

Nuclear speckles: dynamic hubs of gene expression regulation

(2021) İbrahim Avşar Ilık et al.   FEBS Journal

Viral Induced Protein Aggregation: A Mechanism of Immune Evasion

(2021) Elena Muscolino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A condensate-hardening drug blocks RSV replication in vivo

(2021) Jennifer Risso-Ballester et al.   NATURE

Generic nature of the condensed states of proteins

(2021) Monika Fuxreiter et al.   NATURE CELL BIOLOGY

Pathogenesis of human cytomegalovirus in the immunocompromised host

(2021) Paul Griffiths et al.   NATURE REVIEWS MICROBIOLOGY

Evidence That the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments

(2021) Paloma Hidalgo et al.   Viruses-Basel

Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation

(2021) Yiting Yang et al.   Communications Biology

RNA promotes the formation of spatial compartments in the nucleus

(2021) Sofia A. Quinodoz et al.   CELL

Specific RNA interactions promote TDP‐43 multivalent phase separation and maintain liquid properties

(2021) Zachary R Grese et al.   EMBO REPORTS

Nucleation landscape of biomolecular condensates

(2021) Shunsuke F. Shimobayashi et al.   NATURE

Phase separation of Epstein-Barr Virus EBNA2 and Its Coactivator EBNALP controls gene expression

(2020) Qiu Peng et al.   JOURNAL OF VIROLOGY

Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

Regulation of KSHV Latency and Lytic Reactivation

(2020) Grant Broussard et al.   Viruses-Basel

Regulation of the MIE Locus During HCMV Latency and Reactivation

(2020) Abigail L. Dooley et al.   Pathogens

Coalescing replication compartments provide the opportunity for recombination between coinfecting herpesviruses

(2019) Enosh Tomer et al.   FASEB JOURNAL

Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

(2019) David Trombley McSwiggen et al.   eLife

Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism

(2019) Liang Wang et al.   MOLECULAR CELL

The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins

(2019) Izzy Owen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms for Active Regulation of Biomolecular Condensates

(2019) Johannes Söding et al.   TRENDS IN CELL BIOLOGY

Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism

(2019) Elena Muscolino et al.   Nature Microbiology

Physical principles of intracellular organization via active and passive phase transitions

(2018) Joel Berry et al.   REPORTS ON PROGRESS IN PHYSICS

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Kinase-controlled phase transition of membraneless organelles in mitosis

(2018) Arpan Kumar Rai et al.   NATURE

Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories

(2018) Jeanette M. Criglar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence

(2017) Magdalena Weidner-Glunde et al.   JOURNAL OF VIROLOGY

RNA phase transitions in repeat expansion disorders

(2017) Ankur Jain et al.   NATURE

Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles

(2017) Ming-Tzo Wei et al.   Nature Chemistry

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Herpesviruses: epidemiology, pathogenesis, and interventions

(2017) Ke Lan et al.   VIROLOGICA SINICA

Amyloid-like Self-Assembly of a Cellular Compartment

(2016) Elvan Boke et al.   CELL

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

Human cytomegalovirus antiviral drug resistance in hematopoietic stem cell transplantation: current state of the art

(2016) Ana Bela Campos et al.   REVIEWS IN MEDICAL VIROLOGY

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

RNA Controls PolyQ Protein Phase Transitions

(2015) Huaiying Zhang et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Remodeling nuclear architecture allows efficient transport of herpesvirus capsids by diffusion

(2015) Jens B. Bosse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA transcription modulates phase transition-driven nuclear body assembly

(2015) Joel Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Cell Assay for Molecular Diagnostics and Medicine: Monitoring Intracellular Concentrations of Macromolecules by Two-photon Fluorescence Lifetime Imaging

(2015) Artem Pliss et al.   Theranostics

Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

(2015) Sonja Kroschwald et al.   eLife

The life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics

(2014) Pierre M Jean Beltran et al.   Expert Review of Proteomics

Viral and cellular subnuclear structures in human cytomegalovirus-infected cells

(2014) B. L. Strang   JOURNAL OF GENERAL VIROLOGY

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

Analysis of Human Cytomegalovirus-Encoded SUMO Targets and Temporal Regulation of SUMOylation of the Immediate-Early Proteins IE1 and IE2 during Infection

(2014) Eui Tae Kim et al.   PLoS One

Biphasic Euchromatin-to-Heterochromatin Transition on the KSHV Genome Following De Novo Infection

(2013) Zsolt Toth et al.   PLoS Pathogens

Human Cytomegalovirus UL44 Concentrates at the Periphery of Replication Compartments, the Site of Viral DNA Synthesis

(2011) B. L. Strang et al.   JOURNAL OF VIROLOGY

Nucleation of nuclear bodies by RNA

(2011) Sergey P. Shevtsov et al.   NATURE CELL BIOLOGY

Herpesviral replication compartments move and coalesce at nuclear speckles to enhance export of viral late mRNA

(2011) L. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanding the proteome: disordered and alternatively folded proteins

(2011) H. Jane Dyson   QUARTERLY REVIEWS OF BIOPHYSICS

The Epigenetic Landscape of Latent Kaposi Sarcoma-Associated Herpesvirus Genomes

(2010) Thomas Günther et al.   PLoS Pathogens

Chromatin structure regulates human cytomegalovirus gene expression during latency, reactivation and lytic infection

(2009) John Sinclair   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

Virus-Induced Chaperone-Enriched (VICE) Domains Function as Nuclear Protein Quality Control Centers during HSV-1 Infection

(2009) Christine M. Livingston et al.   PLoS Pathogens

Conserved herpesvirus protein kinases

(2007) Edward Gershburg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS