标题
Regulation of the MIE Locus During HCMV Latency and Reactivation
作者
关键词
-
出版物
Pathogens
Volume 9, Issue 11, Pages 869
出版商
MDPI AG
发表日期
2020-10-23
DOI
10.3390/pathogens9110869
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function
- (2020) Catherine S. Adamson et al. Viruses-Basel
- Human cytomegalovirus major immediate early transcripts arise predominantly from the canonical major immediate early promoter in reactivating progenitor-derived dendritic cells
- (2020) Rebecca Mason et al. JOURNAL OF GENERAL VIROLOGY
- Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II
- (2020) Ming Li et al. PLoS Pathogens
- Human cytomegalovirus long noncoding RNA4.9 regulates viral DNA replication
- (2020) Julie Tai-Schmiedel et al. PLoS Pathogens
- Cytomegalovirus Latency and Reactivation: An Intricate Interplay With the Host Immune Response
- (2020) Eleonora Forte et al. Frontiers in Cellular and Infection Microbiology
- FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation
- (2020) Andrew E. Hale et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activator protein-1 transactivation of the major immediate early locus is a determinant of cytomegalovirus reactivation from latency
- (2020) Benjamin A. Krishna et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Role of ARID5B in Acute Lymphoblastic Leukemia and Beyond
- (2020) Peiqi Wang et al. Frontiers in Genetics
- Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways
- (2020) Meaghan H. Hancock et al. mSphere
- Cytoplasmic control of intranuclear polarity by human cytomegalovirus
- (2020) Dean J. Procter et al. NATURE
- Human Cytomegalovirus Genomes Survive Mitosis via the IE19 Chromatin-Tethering Domain
- (2020) Shelby M. Lyon et al. mBio
- HCMV modulation of cellular PI3K/AKT/mTOR signaling: New opportunities for therapeutic intervention?
- (2019) Aaron M. Altman et al. ANTIVIRAL RESEARCH
- Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos
- (2019) Benjamin A. Krishna et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Single-Cell Transcriptome Analysis of CD34+ Stem Cell-Derived Myeloid Cells Infected With Human Cytomegalovirus
- (2019) Melissa Galinato et al. Frontiers in Microbiology
- 5‑Azacytidine treatment results in nuclear exclusion of DNA methyltransferase‑1, as well as reduced proliferation and invasion in human cytomegalovirus‑infected glioblastoma cells
- (2019) Atosa Estekizadeh et al. ONCOLOGY REPORTS
- Cytomegalovirus Infections after Hematopoietic Stem Cell Transplantation: Current Status and Future Immunotherapy
- (2019) Sung-Yeon Cho et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Letermovir for the prevention of cytomegalovirus infection and disease in transplant recipients: an evidence-based review
- (2019) Guy El Helou et al. Infection and Drug Resistance
- Maribavir for Preemptive Treatment of Cytomegalovirus Reactivation
- (2019) Johan Maertens et al. NEW ENGLAND JOURNAL OF MEDICINE
- Alternative promoters drive human cytomegalovirus reactivation from latency
- (2019) Donna Collins-McMillen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human Cytomegalovirus US28 Ligand Binding Activity Is Required for Latency in CD34+ Hematopoietic Progenitor Cells and Humanized NSG Mice
- (2019) Lindsey B. Crawford et al. mBio
- Emergence and Persistence of Letermovir-Resistant Cytomegalovirus in a Patient With Primary Immunodeficiency
- (2019) Stephanie Popping et al. Open Forum Infectious Diseases
- Advances in the treatment of cytomegalovirus
- (2019) B A Krishna et al. BRITISH MEDICAL BULLETIN
- Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency
- (2019) Jason Buehler et al. PLoS Pathogens
- HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation
- (2019) Iliyana Mikell et al. PLoS Pathogens
- Congenital cytomegalovirus infection: epidemiology, prediction, diagnosis, and emerging treatment options for symptomatic infants
- (2019) Nobuhiko Nagano et al. Expert Opinion on Orphan Drugs
- A New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by in vitro Exposure to Letermovir and Ganciclovir
- (2018) Sunwen Chou et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination
- (2018) Ying Zhang et al. BMC CANCER
- SUMOylation of IE2p86 is required for efficient autorepression of the human cytomegalovirus major immediate-early promoter
- (2018) Nina Reuter et al. JOURNAL OF GENERAL VIROLOGY
- miRNA-mediated targeting of human cytomegalovirus reveals biological host and viral targets of IE2
- (2018) Rasmus Møller et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing
- (2018) Miri Shnayder et al. mBio
- Human cytomegalovirus reprogrammes haematopoietic progenitor cells into immunosuppressive monocytes to achieve latency
- (2018) Dihan Zhu et al. Nature Microbiology
- Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
- (2018) Jacob O'Brien et al. Frontiers in Endocrinology
- Maribavir for Refractory or Resistant Cytomegalovirus Infections in Hematopoietic-cell or Solid-organ Transplant Recipients: A Randomized, Dose-ranging, Double-blind, Phase 2 Study
- (2018) Genovefa A Papanicolaou et al. CLINICAL INFECTIOUS DISEASES
- Current and future options for cytomegalovirus reactivation in hematopoietic cell transplantation patients
- (2017) Johan Maertens et al. Future Microbiology
- Correlation Between Expression of Recombinant Proteins and Abundance of H3K4Me3 on the Enhancer of Human Cytomegalovirus Major Immediate-Early Promoter
- (2017) Benjamin P. C. Soo et al. MOLECULAR BIOTECHNOLOGY
- Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency
- (2017) Shu Cheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation
- (2017) Zhao Zha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection
- (2017) Benjamin A. Krishna et al. mBio
- Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein
- (2017) B. A. Krishna et al. Nature Communications
- Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX
- (2017) Dominik Hoelper et al. Nature Communications
- Diagnosis of cytomegalovirus pneumonia by quantitative polymerase chain reaction using bronchial washing fluid from patients with hematologic malignancies
- (2017) Hwa Young Lee et al. Oncotarget
- Infections in Hematopoietic Cell Transplant Recipients: Results From the Organ Transplant Infection Project, a Multicenter, Prospective, Cohort Study
- (2017) Mindy G. Schuster et al. Open Forum Infectious Diseases
- High levels of histone H3 acetylation at the CMV promoter are predictive of stable expression in Chinese hamster ovary cells
- (2016) Benjamin Moritz et al. BIOTECHNOLOGY PROGRESS
- Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis
- (2016) P. Teira et al. BLOOD
- Human cytomegalovirus miR-UL112-1 promotes the down-regulation of viral immediate early-gene expression during latency to prevent T-cell recognition of latently infected cells
- (2016) Betty Lau et al. JOURNAL OF GENERAL VIROLOGY
- Inhibition of the FACT Complex Reduces Transcription from the Human Cytomegalovirus Major Immediate Early Promoter in Models of Lytic and Latent Replication
- (2016) Christine M. O'Connor et al. JOURNAL OF VIROLOGY
- Multiple Transcripts Encode Full-Length Human Cytomegalovirus IE1 and IE2 Proteins during Lytic Infection
- (2016) Kyle C. Arend et al. JOURNAL OF VIROLOGY
- Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling To Enter and Initiate the Early Steps in the Establishment of Latency in CD34 + Human Progenitor Cells
- (2016) Jung Heon Kim et al. JOURNAL OF VIROLOGY
- The HCMV US28 vGPCR induces potent Gαq/PLC-β signaling in monocytes leading to increased adhesion to endothelial cells
- (2016) Shu-en Wu et al. VIROLOGY
- Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer
- (2016) Anne Laugesen et al. Cold Spring Harbor Perspectives in Medicine
- Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication
- (2016) Jason Buehler et al. PLoS Pathogens
- Cytomegalovirus viral load and mortality after haemopoietic stem cell transplantation in the era of pre-emptive therapy: a retrospective cohort study
- (2016) Margaret L Green et al. Lancet Haematology
- Transient activation of human cytomegalovirus lytic gene expression during latency allows cytotoxic T cell killing of latently infected cells
- (2016) B. A. Krishna et al. Scientific Reports
- RapidIn VitroEvolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance
- (2015) Sunwen Chou ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Reduced Mortality of Cytomegalovirus Pneumonia After Hematopoietic Cell Transplantation Due to Antiviral Therapy and Changes in Transplantation Practices
- (2015) Veronique Erard et al. CLINICAL INFECTIOUS DISEASES
- Cytomegalovirus infection in transplant recipients
- (2015) LS Azevedo et al. Clinics
- Human Cytomegalovirus US28 Is Important for Latent Infection of Hematopoietic Progenitor Cells
- (2015) Monica S. Humby et al. JOURNAL OF VIROLOGY
- Histone H4 Lysine 20 (H4K20) Methylation, Expanding the Signaling Potential of the Proteome One Methyl Moiety at a Time
- (2015) Rick van Nuland et al. MOLECULAR & CELLULAR PROTEOMICS
- Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells
- (2015) Simon J. Elsässer et al. NATURE
- Cytomegalovirus latency and reactivation: recent insights into an age old problem
- (2015) Liane Dupont et al. REVIEWS IN MEDICAL VIROLOGY
- CMV promoter mutants with a reduced propensity to productivity loss in CHO cells
- (2015) Benjamin Moritz et al. Scientific Reports
- Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch
- (2015) Benjamin Rauwel et al. eLife
- Cellular defense against latent colonization foiled by human cytomegalovirus UL138 protein
- (2015) S. H. Lee et al. Science Advances
- Maintenance and Replication of the Human Cytomegalovirus Genome during Latency
- (2014) Margaret Tarrant-Elorza et al. Cell Host & Microbe
- The human cytomegalovirus IE1 protein: past and present developments
- (2014) Myriam Scherer et al. Future Virology
- Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage
- (2014) G. Chan et al. JOURNAL OF IMMUNOLOGY
- Host MicroRNA Regulation of Human Cytomegalovirus Immediate Early Protein Translation Promotes Viral Latency
- (2014) C. M. O'Connor et al. JOURNAL OF VIROLOGY
- CTCF Binding to the First Intron of the Major Immediate Early (MIE) Gene of Human Cytomegalovirus (HCMV) Negatively Regulates MIE Gene Expression and HCMV Replication
- (2014) F. P. Martinez et al. JOURNAL OF VIROLOGY
- HCMV Reprogramming of Infected Monocyte Survival and Differentiation: A Goldilocks Phenomenon
- (2014) Emily Stevenson et al. Viruses-Basel
- Mitogen and Stress Activated Kinases Act Co-operatively with CREB during the Induction of Human Cytomegalovirus Immediate-Early Gene Expression from Latency
- (2014) Verity G. Kew et al. PLoS Pathogens
- Immediate-Early (IE) gene regulation of cytomegalovirus: IE1- and pp71-mediated viral strategies against cellular defenses
- (2014) Lilith Torres et al. VIROLOGICA SINICA
- CMV serostatus still has an important prognostic impact in de novo acute leukemia patients after allogeneic stem cell transplantation: a report from the Acute Leukemia Working Party of EBMT
- (2013) M. Schmidt-Hieber et al. BLOOD
- Retinoic Acid Actions through Mammalian Nuclear Receptors
- (2013) Pengxiang Huang et al. CHEMICAL REVIEWS
- Human Cytomegalovirus pUL97 Regulates the Viral Major Immediate Early Promoter by Phosphorylation-Mediated Disruption of Histone Deacetylase 1 Binding
- (2013) T. M. Bigley et al. JOURNAL OF VIROLOGY
- Polycomb Repressive Complex 2 Silences Human Cytomegalovirus Transcription in Quiescent Infection Models
- (2013) C. G. Abraham et al. JOURNAL OF VIROLOGY
- Targeting the JMJD2 Histone Demethylases to Epigenetically Control Herpesvirus Infection and Reactivation from Latency
- (2013) Y. Liang et al. Science Translational Medicine
- Epigenetic Control of Cytomegalovirus Latency and Reactivation
- (2013) Xue-feng Liu et al. Viruses-Basel
- Cis and Trans Acting Factors Involved in Human Cytomegalovirus Experimental and Natural Latent Infection of CD14 (+) Monocytes and CD34 (+) Cells
- (2013) Cyprian C. Rossetto et al. PLoS Pathogens
- Histone H3 phosphorylation – A versatile chromatin modification for different occasions
- (2012) Anna Sawicka et al. BIOCHIMIE
- Efficient Human Cytomegalovirus Reactivation Is Maturation Dependent in the Langerhans Dendritic Cell Lineage and Can Be Studied using a CD14+Experimental Latency Model
- (2012) Margaret M. Huang et al. JOURNAL OF VIROLOGY
- Histone H3 Lysine 4 Methylation Marks Postreplicative Human Cytomegalovirus Chromatin
- (2012) Alexandra Nitzsche et al. JOURNAL OF VIROLOGY
- Human Cytomegalovirus Stimulates Monocyte-to-Macrophage Differentiation via the Temporal Regulation of Caspase 3
- (2012) G. Chan et al. JOURNAL OF VIROLOGY
- A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals
- (2012) Manuel Garber et al. MOLECULAR CELL
- Risk Factors for Cytomegalovirus Retinitis in Patients with Cytomegalovirus Viremia after Hematopoietic Stem Cell Transplantation
- (2012) Sohee Jeon et al. OPHTHALMOLOGY
- Cytomegalovirus disease in lung transplantation: impact of recipient seropositivity and duration of antiviral prophylaxis
- (2012) S.P. Hammond et al. Transplant Infectious Disease
- Human cytomegalovirus entry into cells
- (2012) Adam L Vanarsdall et al. Current Opinion in Virology
- Promoter methylation and transgene copy numbers predict unstable protein production in recombinant chinese hamster ovary cell lines
- (2011) Andrea Osterlehner et al. BIOTECHNOLOGY AND BIOENGINEERING
- Regulation of chromatin by histone modifications
- (2011) Andrew J Bannister et al. CELL RESEARCH
- Epigenetic Modifications
- (2011) Diane E. Handy et al. CIRCULATION
- CTF/NF1 transcription factors act as potent genetic insulators for integrating gene transfer vectors
- (2011) A Gaussin et al. GENE THERAPY
- Pioneer transcription factors: establishing competence for gene expression
- (2011) K. S. Zaret et al. GENES & DEVELOPMENT
- KAP1 Protein: An Enigmatic Master Regulator of the Genome
- (2011) Sushma Iyengar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Virally induced changes in cellular microRNAs maintain latency of human cytomegalovirus in CD34+ progenitors
- (2011) E. Poole et al. JOURNAL OF GENERAL VIROLOGY
- Role of Promyelocytic Leukemia Protein in Host Antiviral Defense
- (2011) Marie-Claude Geoffroy et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- The Latency-Associated UL138 Gene Product of Human Cytomegalovirus Sensitizes Cells to Tumor Necrosis Factor Alpha (TNF- ) Signaling by Upregulating TNF- Receptor 1 Cell Surface Expression
- (2011) C. Montag et al. JOURNAL OF VIROLOGY
- Inhibition of Inflammatory Interleukin-6 Activity via Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase Signaling Antagonizes Human Cytomegalovirus Reactivation from Dendritic Cells
- (2011) M. B. Reeves et al. JOURNAL OF VIROLOGY
- The Efficacy and Safety of 200 Days Valganciclovir Cytomegalovirus Prophylaxis in High-Risk Kidney Transplant Recipients
- (2010) A. Humar et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Antiviral Drug Resistance of Human Cytomegalovirus
- (2010) N. S. Lurain et al. CLINICAL MICROBIOLOGY REVIEWS
- DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines
- (2010) Yuansheng Yang et al. JOURNAL OF BIOTECHNOLOGY
- The Elk-1 and Serum Response Factor Binding Sites in the Major Immediate-Early Promoter of Human Cytomegalovirus Are Required for Efficient Viral Replication in Quiescent Cells and Compensate for Inactivation of the NF- B Sites in Proliferating Cells
- (2010) P. Caposio et al. JOURNAL OF VIROLOGY
- The Activator Protein 1 Binding Motifs within the Human Cytomegalovirus Major Immediate-Early Enhancer Are Functionally Redundant and Act in a Cooperative Manner with the NF- B Sites during Acute Infection
- (2010) E. Isern et al. JOURNAL OF VIROLOGY
- Cellular and Viral Control over the Initial Events of Human Cytomegalovirus Experimental Latency in CD34+ Cells
- (2010) R. T. Saffert et al. JOURNAL OF VIROLOGY
- Gfi1 and Gfi1b: key regulators of hematopoiesis
- (2010) L T van der Meer et al. LEUKEMIA
- Experimental human cytomegalovirus latency in CD14+ monocytes
- (2010) D. Hargett et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection
- (2010) Michael J. Cannon et al. REVIEWS IN MEDICAL VIROLOGY
- Chromatin-mediated regulation of cytomegalovirus gene expression
- (2010) Matthew B. Reeves VIRUS RESEARCH
- Intrinsic cellular defense mechanisms targeting human cytomegalovirus
- (2010) Nina Tavalai et al. VIRUS RESEARCH
- A Viral microRNA Down-Regulates Multiple Cell Cycle Genes through mRNA 5′UTRs
- (2010) Finn Grey et al. PLoS Pathogens
- Human Cytomegalovirus UL29/28 Protein Interacts with Components of the NuRD Complex Which Promote Accumulation of Immediate-Early RNA
- (2010) Scott S. Terhune et al. PLoS Pathogens
- Nuclear functions of the HMG proteins
- (2009) Raymond Reeves Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Chromatin structure regulates human cytomegalovirus gene expression during latency, reactivation and lytic infection
- (2009) John Sinclair Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Lytic infection of permissive cells with human cytomegalovirus is regulated by an intrinsic 'pre-immediate-early' repression of viral gene expression mediated by histone post-translational modification
- (2009) I. J. Groves et al. JOURNAL OF GENERAL VIROLOGY
- Activation of Peroxisome Proliferator-Activated Receptor Gamma by Human Cytomegalovirus for De Novo Replication Impairs Migration and Invasiveness of Cytotrophoblasts from Early Placentas
- (2009) B. Rauwel et al. JOURNAL OF VIROLOGY
- The CREB Site in the Proximal Enhancer Is Critical for Cooperative Interaction with the Other Transcription Factor Binding Sites To Enhance Transcription of the Major Intermediate-Early Genes in Human Cytomegalovirus-Infected Cells
- (2009) P. Lashmit et al. JOURNAL OF VIROLOGY
- Human Cytomegalovirus Protein pp71 Induces Daxx SUMOylation
- (2009) J. Hwang et al. JOURNAL OF VIROLOGY
- Analysis of Human Cytomegalovirus-Encoded MicroRNA Activity during Infection
- (2009) N. Stern-Ginossar et al. JOURNAL OF VIROLOGY
- Characterization of a Novel Golgi Apparatus-Localized Latency Determinant Encoded by Human Cytomegalovirus
- (2009) A. Petrucelli et al. JOURNAL OF VIROLOGY
- Sp1 Phosphorylation and Its Regulation of Gene Transcription
- (2009) N. Y. Tan et al. MOLECULAR AND CELLULAR BIOLOGY
- Transgene Expression Is Associated with Copy Number and Cytomegalovirus Promoter Methylation in Transgenic Pigs
- (2009) Qingran Kong et al. PLoS One
- The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses
- (2009) Christina Paulus et al. Viruses-Basel
- Antiviral strategies to combat cytomegalovirus infections in transplant recipients
- (2008) P LISCHKA et al. CURRENT OPINION IN PHARMACOLOGY
- Identification and function of human cytomegalovirus microRNAs
- (2008) Finn Grey et al. JOURNAL OF CLINICAL VIROLOGY
- Dynamic Histone H3 Acetylation and Methylation at Human Cytomegalovirus Promoters during Replication in Fibroblasts
- (2008) C. Cuevas-Bennett et al. JOURNAL OF VIROLOGY
- Temporal Dynamics of Cytomegalovirus Chromatin Assembly in Productively Infected Human Cells
- (2008) A. Nitzsche et al. JOURNAL OF VIROLOGY
- Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: Implications for latency
- (2008) E. Murphy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Repression of human cytomegalovirus major immediate early gene expression by the cellular transcription factor CCAAT displacement protein
- (2008) J. Lewis Stern et al. VIROLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started