Biological active ingredients of Astragali Radix and its mechanisms in treating cardiovascular and cerebrovascular diseases

Phytochemistry and cardiovascular protective effects of Huang‐Qi (Astragali Radix)

(2021) Hui‐fei Su et al.   MEDICINAL RESEARCH REVIEWS

Astragaloside IV alleviates atherosclerosis through targeting circ_0000231/miR-135a-5p/CLIC4 axis in AS cell model in vitro

(2021) Xiao Shao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARγ pathway after cerebral ischemia/reperfusion injury in rats

(2021) Lin Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Exosomes from neuronal stem cells may protect the heart from ischaemia/reperfusion injury via JAK1/2 and gp130

(2021) Miroslava Katsur et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Protective effects of Astragaloside IV against oxidative injury and apoptosis in cultured astrocytes by regulating Nrf2/JNK signaling

(2021) Jintao Yang et al.   EXPERIMENTAL BRAIN RESEARCH

Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy

(2021) Fei Tang et al.   Frontiers in Pharmacology

Astragaloside IV prevents acute myocardial infarction by inhibiting the TLR4/MyD88/NF‐κB signaling pathway

(2021) Hui Shi et al.   JOURNAL OF FOOD BIOCHEMISTRY

Calycosin Preserves BDNF/TrkB Signaling and Reduces Post-Stroke Neurological Injury after Cerebral Ischemia by Reducing Accumulation of Hypertrophic and TNF-α-Containing Microglia in Rats

(2020) Chien-Chin Hsu et al.   Journal of Neuroimmune Pharmacology

Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats

(2020) Yu-shan Ren et al.   Journal of Proteomics

Astragaloside IV enhances GATA-4 mediated myocardial protection effect in Hypoxia/Reoxygenation injured H9c2 cells

(2020) Jing-Jing Yang et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia

(2020) Man Li et al.   ACTA PHARMACOLOGICA SINICA

Astragaloside IV protects human cardiomyocytes from hypoxia/reoxygenation injury by regulating miR-101a

(2020) Yang Wu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A Review of the Pharmacological Action of Astragalus Polysaccharide

(2020) Yijun Zheng et al.   Frontiers in Pharmacology

Astragaloside IV Exerts Cognitive Benefits and Promotes Hippocampal Neurogenesis in Stroke Mice by Downregulating Interleukin-17 Expression via Wnt Pathway

(2020) Li Sun et al.   Frontiers in Pharmacology

Efficiency of Traditional Chinese medicine targeting the Nrf2/HO-1 signaling pathway

(2020) Bin Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Pharmacokinetic Analysis of Huangqi Guizhi Wuwu Decoction on Blood and Brain Tissue in Rats with Normal and Cerebral Ischemia-Reperfusion Injury by Microdialysis with HPLC-MS/MS

(2020) Hao-Zhen Zheng et al.   Drug Design Development and Therapy

Astragaloside IV improves neurobehavior and promotes hippocampal neurogenesis in MCAO rats though BDNF-TrkB signaling pathway

(2020) Guang-xiao Ni et al.   BIOMEDICINE & PHARMACOTHERAPY

Non-coding RNAs participate in the ischemia-reperfusion injury

(2020) Soudeh Ghafouri-Fard et al.   BIOMEDICINE & PHARMACOTHERAPY

The novel Nrf2 activator CDDO‐EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice

(2020) Xia Lei et al.   CNS Neuroscience & Therapeutics

Astragaloside and/or Hydroxysafflor Yellow A Attenuates Oxygen-Glucose Deprivation-Induced Cultured Brain Microvessel Endothelial Cell Death through Downregulation of PHLPP-1

(2020) Jinyi Cao et al.   Evidence-based Complementary and Alternative Medicine

Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone deacetylase inhibition

(2020) Baokai Dou et al.   Frontiers of Medicine

Protective Effects of Astragaloside IV against LPS-Induced Endometritis in Mice through Inhibiting Activation of the NF-κB, p38 and JNK Signaling Pathways

(2019) Fengge Wang et al.   MOLECULES

Astragaloside IV Protects Against Oxidized Low-Density Lipoprotein (ox-LDL)-Induced Endothelial Cell Injury by Reducing Oxidative Stress and Inflammation

(2019) Zhongsheng Zhu et al.   MEDICAL SCIENCE MONITOR

Astragaloside IV alleviates heart failure by promoting angiogenesis through the JAK-STAT3 pathway

(2019) Yan-Bo Sui et al.   PHARMACEUTICAL BIOLOGY

A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine

(2019) Zhenzhen Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Astragaloside IV against Cerebral Ischemia/Reperfusion Injury: Suppression of Apoptosis via Promotion of P62-LC3-Autophagy

(2019) Yi Zhang et al.   MOLECULES

Astragaloside IV Protects Primary Cerebral Cortical Neurons from Oxygen and Glucose Deprivation/Reoxygenation by Activating the PKA/CREB Pathway

(2019) Bingjie Xue et al.   NEUROSCIENCE

Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway

(2019) Songyi Cheng et al.   LIFE SCIENCES

Astragaloside IV Exerts a Myocardial Protective Effect against Cardiac Hypertrophy in Rats, Partially via Activating the Nrf2/HO-1 Signaling Pathway

(2019) Pei Nie et al.   Oxidative Medicine and Cellular Longevity

Astragaloside IV Attenuates Myocardial Ischemia-Reperfusion Injury from Oxidative Stress by Regulating Succinate, Lysophospholipid Metabolism, and ROS Scavenging System

(2019) Miaomiao Jiang et al.   Oxidative Medicine and Cellular Longevity

Astragaloside IV protects cardiomyocytes from hypoxia-induced injury by down-regulation of lncRNA GAS5

(2019) Jian Du et al.   BIOMEDICINE & PHARMACOTHERAPY

Uncovering the pharmacological mechanism of Carthamus tinctorius L. on cardiovascular disease by a systems pharmacology approach

(2019) Guohua Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Nutritional preconditioning induced by astragaloside Ⅳ on isolated hearts and cardiomyocytes against myocardial ischemia injury via improving Bcl-2-mediated mitochondrial function

(2019) Yong Luo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Calycosin-7-O-β-D-glucoside Attenuates OGD/R-Induced Damage by Preventing Oxidative Stress and Neuronal Apoptosis via the SIRT1/FOXO1/PGC-1α Pathway in HT22 Cells

(2019) Xiangli Yan et al.   NEURAL PLASTICITY

Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-/-) mice by activating PI3K/AKT signaling and suppressing TRL4/NF-κB signaling

(2019) Nanding Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Antitumor effects of immunity-enhancing traditional Chinese medicine

(2019) Yeshu Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Astragaloside IV alleviates ischemia reperfusion-induced apoptosis by inhibiting the activation of key factors in death receptor pathway and mitochondrial pathway

(2019) Fei Yin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the Janus Kinase 2 and Signal Transducer and Activator of Transcription 3 Signaling Pathway

(2019) ZhengHu Xu et al.   PHARMACOLOGY

Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways

(2018) Bo Yin et al.   ACTA PHARMACOLOGICA SINICA

Simultaneous quantification of multiple components in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Huangqi decoction

(2018) Jia-Kai Zeng et al.   BIOMEDICAL CHROMATOGRAPHY

Astragaloside IV protects against the pathological cardiac hypertrophy in mice

(2018) Zhen-hu Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Astragaloside IV reduces the hypoxia-induced injury in PC-12 cells by inhibiting expression of miR-124

(2018) Wei Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Astragalosides increase the cardiac diastolic function and regulate the “Calcium sensing receptor-protein kinase C-protein phosphatase 1” pathway in rats with heart failure

(2018) Yansu Ji et al.   BIOMEDICINE & PHARMACOTHERAPY

Astragaloside IV inhibits ventricular remodeling and improves fatty acid utilization in rats with chronic heart failure

(2018) Bin Tang et al.   BIOSCIENCE REPORTS

TA-65, A Telomerase Activator, Improves Cardiovascular Markers in Patients with Metabolic Syndrome

(2018) Maria Luz Fernandez et al.   CURRENT PHARMACEUTICAL DESIGN

Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome

(2018) Yu Wan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Astragaloside IV Improves Vasodilatation Function by Regulating the PI3K/Akt/eNOS Signaling Pathway in Rat Aorta Endothelial Cells

(2018) Xiang-Ping Lin et al.   JOURNAL OF VASCULAR RESEARCH

Astragaloside IV protects blood-brain barrier integrity from LPS-induced disruption via activating Nrf2 antioxidant signaling pathway in mice

(2018) Hongli Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Preclinical Systematic Review and Meta-Analysis of Astragaloside IV for Myocardial Ischemia/Reperfusion Injury

(2018) Qun Zheng et al.   Frontiers in Physiology

Cycloastragenol ameliorates experimental heart damage in rats by promoting myocardial autophagy via inhibition of AKT1-RPS6KB1 signaling

(2018) Jing Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Astragaloside VI Promotes Neural Stem Cell Proliferation and Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injury via Activating EGFR/MAPK Signaling Cascades

(2018) Xi Chen et al.   MOLECULAR NEUROBIOLOGY

Astragaloside IV reversed the autophagy and oxidative stress induced by the intestinal microbiota of AIS in mice

(2018) Nan Xu et al.   JOURNAL OF MICROBIOLOGY

Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection

(2018) Meili Lu et al.   Frontiers in Pharmacology

Huangqi injection in the treatment of chronic heart failure

(2017) Kaihuan Wang et al.   MEDICINE

Astragaloside attenuates myocardial injury in a rat model of acute myocardial infarction by upregulating hypoxia inducible factor-1α and Notch1/Jagged1 signaling

(2017) Junmin Yu et al.   Molecular Medicine Reports

Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms

(2017) Hui-Lin Wang et al.   Oxidative Medicine and Cellular Longevity

Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy

(2017) Shu Zhang et al.   Cell Death & Disease

Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation

(2017) Zhiwei Dong et al.   Scientific Reports

Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic

(2017) Ping Liu et al.   Aging and Disease

PG2 for patients with acute spontaneous intracerebral hemorrhage: a double-blind, randomized, placebo-controlled study

(2017) Chun-Chung Chen et al.   Scientific Reports

Protective effects of Astragalus polysaccharides against endothelial dysfunction in hypertrophic rats induced by isoproterenol

(2016) Ronghui Han et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis

(2016) Dena Ettehad et al.   LANCET

A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study

(2016) Laura Salvador et al.   REJUVENATION RESEARCH

Regression of coronary atherosclerosis: Current evidence and future perspectives

(2016) Konstantinos C. Koskinas et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Pharmacokinetics, metabolism, and excretion of cycloastragenol, a potent telomerase activator in rats

(2016) Peng-Kai Ma et al.   XENOBIOTICA

Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation

(2015) Meng Mei et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Study of pharmacokinetic profiles and characteristics of active components and their metabolites in rat plasma following oral administration of the water extract of Astragali radix using UPLC–MS/MS

(2015) Jian Shi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Function and mechanism of toll-like receptors in cerebral ischemic tolerance: from preconditioning to treatment

(2015) Peng-Fei Wang et al.   Journal of Neuroinflammation

Biological Active Ingredients of Traditional Chinese Herb Astragalus membranaceus on Treatment of Diabetes: A Systematic Review

(2015) Zhang Kai et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Calycosin-7-O-β-d-glucoside attenuates ischemia-reperfusion injury in vivo via activation of the PI3K/Akt pathway

(2015) MIN REN et al.   Molecular Medicine Reports

Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase?

(2015) Yuanyuan Cheng et al.   Oxidative Medicine and Cellular Longevity

Astragaloside IV Attenuates Injury Caused by Myocardial Ischemia/Reperfusion in Rats via Regulation of Toll-Like Receptor 4/Nuclear Factor-κB Signaling Pathway

(2015) Meili Lu et al.   PHYTOTHERAPY RESEARCH

Beneficial Effect of Astragalosides on Stroke Condition Using PC12 Cells under Oxygen Glucose Deprivation and Reperfusion

(2014) Bi-Ying Chiu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Astragalus polysaccharide inhibits isoprenaline-induced cardiac hypertrophy via suppressing Ca2+-mediated calcineurin/NFATc3 and CaMKII signaling cascades

(2014) Hongliang Dai et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Calycosin-7-O-β-d-glucoside regulates nitric oxide /caveolin-1/matrix metalloproteinases pathway and protects blood–brain barrier integrity in experimental cerebral ischemia–reperfusion injury

(2014) Shuping Fu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats

(2014) Yong Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A Review of Recent Research Progress on the Astragalus Genus

(2014) Xiaoxia Li et al.   MOLECULES

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Pharmaceutical properties of calycosin, the major bioactive isoflavonoid in the dry root extract ofRadix astragali

(2014) JunQing Gao et al.   PHARMACEUTICAL BIOLOGY

Review of the Botanical Characteristics, Phytochemistry, and Pharmacology ofAstragalus membranaceus(Huangqi)

(2014) Juan Fu et al.   PHYTOTHERAPY RESEARCH

Pharmacokinetic Interaction of Astragaloside IV with Atractylenolide I and Prim-O-Glucosylcimifugin in Male Sprague Dawley Rats

(2014) Jue Song et al.   PLANTA MEDICA

Neuroprotective Effect of TAT-14-3-3ε Fusion Protein against Cerebral Ischemia/Reperfusion Injury in Rats

(2014) Yuanjun Zhu et al.   PLoS One

Novel Drugs Development for Cardio-/Cerebrovascular Diseases

(2014) Joen-Rong Sheu et al.   Biomed Research International

Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-α-treated human vascular endothelial cells by blocking NF-κB activation

(2013) Yu-ping Zhu et al.   ACTA PHARMACOLOGICA SINICA

Astragaloside IV reduces cerebral edema post-ischemia/reperfusion correlating the suppression of MMP-9 and AQP4

(2013) Min Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Negative regulation of TBK1-mediated antiviral immunity

(2013) Wei Zhao   FEBS LETTERS

Dietary safety of cycloastragenol from Astragalus spp.: Subchronic toxicity and genotoxicity studies

(2013) Nancy J. Szabo   FOOD AND CHEMICAL TOXICOLOGY

Astragaloside IV attenuates inflammatory cytokines by inhibiting TLR4/NF-кB signaling pathway in isoproterenol-induced myocardial hypertrophy

(2013) Juan Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Pharmacokinetics and tolerance of toal astragalosides after intravenous infusion of astragalosides injection in healthy Chinese volunteers

(2013) Meijuan Xu et al.   PHYTOMEDICINE

A Natural Product Telomerase Activator as Part of a Health Maintenance Program: Metabolic and Cardiovascular Response

(2013) Calvin B. Harley et al.   REJUVENATION RESEARCH

Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats

(2012) Chao Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Astragaloside IV protects against focal cerebral ischemia/reperfusion injury correlating to suppression of neutrophils adhesion-related molecules

(2012) Min Li et al.   NEUROCHEMISTRY INTERNATIONAL

Study of the Effects of Total Flavonoids of Astragalus on Atherosclerosis Formation and Potential Mechanisms

(2012) Deqing Wang et al.   Oxidative Medicine and Cellular Longevity

Huangqi Injection (a Traditional Chinese Patent Medicine) for Chronic Heart Failure: A Systematic Review

(2011) Shufei Fu et al.   PLoS One

In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator

(2010) Jing Zhu et al.   Drug Metabolism and Pharmacokinetics

Effect of Astragaloside IV on the General and Peripartum Reproductive Toxicity in Sprague-Dawley Rats

(2010) Wan Xuying et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Abundance of a distinct cluster of telomere t-stumps in advanced breast cancer cell line

(2010) REKHA B. PAI et al.   Oncology Letters

Effect of astragaloside IV on the embryo-fetal development of Sprague-Dawley rats and New Zealand White rabbits

(2009) Zhu Jiangbo et al.   JOURNAL OF APPLIED TOXICOLOGY

Protective effect of Astragalus polysaccharides on ATP binding cassette transporter A1 in THP-1 derived foam cells exposed to tumor necrosis factor-alpha

(2009) Yan-Fu Wang et al.   PHYTOTHERAPY RESEARCH

Effect of total flavonoid fraction of Astragalus complanatus R.Brown on angiotensin II-induced portal-vein contraction in hypertensive rats

(2008) B. Xue et al.   PHYTOMEDICINE