ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination

Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair

(2021) Annika Pfeiffer et al.   JOURNAL OF CELL SCIENCE

Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex

(2021) Román González-Prieto et al.   Cell Reports

AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation

(2021) Indrajeet Ghodke et al.   MOLECULAR CELL

Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells

(2021) Jone Michelena et al.   Life Science Alliance

ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication

(2021) Dejie Wang et al.   Science Advances

Making Connections: Integrative Signaling Mechanisms Coordinate DNA Break Repair in Chromatin

(2021) Anthony Sanchez et al.   Frontiers in Genetics

53BP1: a DSB escort

(2020) Zachary Mirman et al.   GENES & DEVELOPMENT

FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function

(2020) Mengfan Tang et al.   Cell Reports

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations

(2020) Dervla M. Connaughton et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients

(2020) Katja Apelt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair

(2019) Naike Salvador Moreno et al.   NUCLEIC ACIDS RESEARCH

H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

(2019) Kyosuke Nakamura et al.   NATURE CELL BIOLOGY

LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation

(2019) Kirk L West et al.   NUCLEIC ACIDS RESEARCH

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

(2019) Jae Jin Kim et al.   GENES & DEVELOPMENT

Stabilization of chromatin topology safeguards genome integrity

(2019) Fena Ochs et al.   NATURE

GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival

(2019) Xiaopeng Lu et al.   NUCLEIC ACIDS RESEARCH

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

(2018) Rajat Gupta et al.   CELL

Depletion of A-type lamins and Lap2α reduces 53BP1 accumulation at UV-induced DNA lesions and Lap2α protein is responsible for compactness of irradiated chromatin

(2018) Eva Bártová et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Protein Dynamics in Complex DNA Lesions

(2018) Radoslav Aleksandrov et al.   MOLECULAR CELL

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells

(2018) Harveer Dev et al.   NATURE CELL BIOLOGY

Caught with One's Zinc Fingers in the Genome Integrity Cookie Jar

(2018) Caroline K. Vilas et al.   TRENDS IN GENETICS

Comprehensive Characterization of Cancer Driver Genes and Mutations

(2018) Matthew H. Bailey et al.   CELL

The pendulum of the Ku-Ku clock

(2018) Atsushi Shibata et al.   DNA REPAIR

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

(2018) Hind Ghezraoui et al.   NATURE

The shieldin complex mediates 53BP1-dependent DNA repair

(2018) Sylvie M. Noordermeer et al.   NATURE

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair

(2017) Justin W.C. Leung et al.   GENES & DEVELOPMENT

SUMO in the DNA Double-Stranded Break Response: Similarities, Differences, and Cooperation with Ubiquitin

(2017) Joanna R. Morris et al.   JOURNAL OF MOLECULAR BIOLOGY

TIRR regulates 53BP1 by masking its histone methyl-lysine binding function

(2017) Pascal Drané et al.   NATURE

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

(2017) Beatrice Rondinelli et al.   NATURE CELL BIOLOGY

PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection

(2017) Alexis Fouquin et al.   NUCLEIC ACIDS RESEARCH

SUMO, a small, but powerful, regulator of double-strand break repair

(2017) Alexander J. Garvin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

(2017) Martijn S Luijsterburg et al.   eLife

A Quantitative Analysis of Subclonal and Clonal Gene Mutations before and after Therapy in Chronic Lymphocytic Leukemia

(2016) N. A. Amin et al.   CLINICAL CANCER RESEARCH

Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cell-extracellular matrix adhesion for migration

(2016) SEO HEE NAM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting DNA Repair in Cancer: Beyond PARP Inhibitors

(2016) Jessica S. Brown et al.   Cancer Discovery

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

(2015) Fade Gong et al.   GENES & DEVELOPMENT

Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells

(2015) Doohyung Lee et al.   HEPATOLOGY

Non-coding recurrent mutations in chronic lymphocytic leukaemia

(2015) Xose S. Puente et al.   NATURE

Screen for multi-SUMO–binding proteins reveals a multi-SIM–binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin

(2015) Elisa Aguilar-Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT 2 Domain with γH2AX

(2015) Robert A. Baldock et al.   Cell Reports

PTIP associates with Artemis to dictate DNA repair pathway choice

(2014) Jiadong Wang et al.   GENES & DEVELOPMENT

Interplay between the DNA Damage Proteins MDC1 and ATM in the Regulation of the Spindle Assembly Checkpoint

(2014) Yifat Eliezer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A rapid, comprehensive system for assaying DNA repair activity and cytotoxic effects of DNA-damaging reagents

(2014) Nan Jia et al.   Nature Protocols

Characterization of the SUMO-Binding Activity of the Myeloproliferative and Mental Retardation (MYM)-Type Zinc Fingers in ZNF261 and ZNF198

(2014) Catherine M. Guzzo et al.   PLoS One

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

(2014) Robert Huether et al.   Nature Communications

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

(2014) F. Tirode et al.   Cancer Discovery

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

(2013) Elsa Callen et al.   CELL

To spread or not to spread—chromatin modifications in response to DNA damage

(2013) Matthias Altmeyer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

Sumoylation of MDC1 is important for proper DNA damage response

(2012) Kuntian Luo et al.   EMBO JOURNAL

Systematic Identification of Functional Residues in Mammalian Histone H2AX

(2012) W.-T. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Novel mutations target distinct subgroups of medulloblastoma

(2012) Giles Robinson et al.   NATURE

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Correct End Use during End Joining of Multiple Chromosomal Double Strand Breaks Is Influenced by Repair Protein RAD50, DNA-dependent Protein Kinase DNA-PKcs, and Transcription Context

(2011) Amanda Gunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

(2011) Lili Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

(2009) G. Shao et al.   GENES & DEVELOPMENT

The ubiquitin landscape at DNA double-strand breaks

(2009) Troy E. Messick et al.   JOURNAL OF CELL BIOLOGY

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

(2009) Joanna R. Morris et al.   NATURE

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

A rapid non-radioactive technique for measurement of repair synthesis in primary human fibroblasts by incorporation of ethynyl deoxyuridine (EdU)

(2009) S. Limsirichaikul et al.   NUCLEIC ACIDS RESEARCH

ZNF198 Stabilizes the LSD1–CoREST–HDAC1 Complex on Chromatin through Its MYM-Type Zinc Fingers

(2008) Christian B. Gocke et al.   PLoS One