ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair

A Quantitative Analysis of Subclonal and Clonal Gene Mutations before and after Therapy in Chronic Lymphocytic Leukemia

(2016) N. A. Amin et al.   CLINICAL CANCER RESEARCH

The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair

(2016) Hoi-Man Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of modified nucleosome recognition by 53BP1

(2016) Marcus D. Wilson et al.   NATURE

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

(2015) Fade Gong et al.   GENES & DEVELOPMENT

Non-coding recurrent mutations in chronic lymphocytic leukaemia

(2015) Xose S. Puente et al.   NATURE

Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection

(2014) Nodar Makharashvili et al.   MOLECULAR CELL

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

(2014) Robert Huether et al.   Nature Communications

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

(2014) F. Tirode et al.   Cancer Discovery

A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance

(2014) Simran Khurana et al.   Cell Reports

BRCA1 Is a Histone-H2A-Specific Ubiquitin Ligase

(2014) Reinhard Kalb et al.   Cell Reports

Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling

(2014) Justin W. Leung et al.   PLoS Genetics

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining

(2013) Angela Helfricht et al.   CELL CYCLE

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone marks: repairing DNA breaks within the context of chromatin

(2012) Kyle M. Miller et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1

(2012) Chang Xu et al.   FEBS LETTERS

RAP80 Protein Is Important for Genomic Stability and Is Required for Stabilizing BRCA1-A Complex at DNA Damage Sitesin Vivo

(2012) Jiaxue Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic Identification of Functional Residues in Mammalian Histone H2AX

(2012) W.-T. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone H2A.Z Controls a Critical Chromatin Remodeling Step Required for DNA Double-Strand Break Repair

(2012) Ye Xu et al.   MOLECULAR CELL

Novel mutations target distinct subgroups of medulloblastoma

(2012) Giles Robinson et al.   NATURE

A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response

(2012) Britt Adamson et al.   NATURE CELL BIOLOGY

Loss of BRCA1-A Complex Function in RAP80 Null Tumor Cells

(2012) Chunjing Bian et al.   PLoS One

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair

(2012) J. W. C. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Links between genome integrity and BRCA1 tumor suppression

(2012) Mischa L. Li et al.   TRENDS IN BIOCHEMICAL SCIENCES

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

(2011) Y. Hu et al.   GENES & DEVELOPMENT

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

NBA1/MERIT40 and BRE Interaction Is Required for the Integrity of Two Distinct Deubiquitinating Enzyme BRCC36-containing Complexes

(2011) Xin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection

(2011) Kara A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correct End Use during End Joining of Multiple Chromosomal Double Strand Breaks Is Influenced by Repair Protein RAD50, DNA-dependent Protein Kinase DNA-PKcs, and Transcription Context

(2011) Amanda Gunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

(2011) Lili Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crypton transposons: identification of new diverse families and ancient domestication events

(2011) Kenji K Kojima et al.   Mobile DNA

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes

(2010) Beth A. Helmink et al.   NATURE

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

(2010) Shan Zha et al.   NATURE

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

(2009) G. Shao et al.   GENES & DEVELOPMENT

MERIT40 facilitates BRCA1 localization and DNA damage repair

(2009) L. Feng et al.   GENES & DEVELOPMENT

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

(2009) B. Wang et al.   GENES & DEVELOPMENT

A Selective Requirement for 53BP1 in the Biological Response to Genomic Instability Induced by Brca1 Deficiency

(2009) Liu Cao et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function

(2009) J Nikkilä et al.   ONCOGENE

Histone Ubiquitination Associates with BRCA1-Dependent DNA Damage Response

(2008) J. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY