Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization

The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention

(2022) R. David Andrew et al.   Neurocritical Care

Brain vulnerability and viability after ischaemia

(2021) Stefano G. Daniele et al.   NATURE REVIEWS NEUROSCIENCE

Neuronal Swelling: A Non-osmotic Consequence of Spreading Depolarization

(2021) Julia A. Hellas et al.   Neurocritical Care

Cerebrospinal fluid influx drives acute ischemic tissue swelling

(2020) Humberto Mestre et al.   SCIENCE

The role of spreading depolarizations and electrographic seizures in early injury progression of the rat photothrombosis stroke model

(2020) Karl Schoknecht et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cellular mechanisms underlying the rapid depolarization caused by oxygen and glucose deprivation in layer III pyramidal cells of the somatosensory cortex

(2020) Hiroki Toyoda et al.   NEUROSCIENCE RESEARCH

Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors

(2020) Takahisa Hanada   Biomolecules

Glial glutamate transporter GLT ‐1 determines susceptibility to spreading depression in the mouse cerebral cortex

(2020) Hidenori Aizawa et al.   GLIA

Ouabain Modulates the Functional Interaction Between Na,K-ATPase and NMDA Receptor

(2020) Evgeny E. Akkuratov et al.   MOLECULAR NEUROBIOLOGY

Toward a Glutamate Hypothesis of Frontotemporal Dementia

(2019) Alberto Benussi et al.   Frontiers in Neuroscience

Correlates of Spreading Depolarization, Spreading Depression, and Negative Ultraslow Potential in Epidural Versus Subdural Electrocorticography

(2019) Jens P. Dreier et al.   Frontiers in Neuroscience

What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?

(2019) Raimund Helbok et al.   Neurocritical Care

Cortical Spreading Depression in the Setting of Traumatic Brain Injury

(2019) Sauson Soldozy et al.   World Neurosurgery

Prognostic Value of Spreading Depolarizations in Patients With Severe Traumatic Brain Injury

(2019) Jed A. Hartings et al.   JAMA Neurology

Terminal spreading depolarization and electrical silence in death of human cerebral cortex

(2018) Jens P. Dreier et al.   ANNALS OF NEUROLOGY

The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex

(2018) Janos Lückl et al.   BRAIN

Ketamine reduces deleterious consequences of spreading depolarizations

(2018) Katelyn M. Reinhart et al.   EXPERIMENTAL NEUROLOGY

Systematic review of the pharmacological agents that have been tested against spreading depolarizations

(2018) Anna Klass et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cortical spreading depression denotes concussion injury

(2018) James Bouley et al.   JOURNAL OF NEUROTRAUMA

A pharmaco-metabolomics approach in a clinical trial of ALS: Identification of predictive markers of progression

(2018) Hélène Blasco et al.   PLoS One

Warburg effect hypothesis in autism Spectrum disorders

(2018) Alexandre Vallée et al.   Molecular Brain

Brainstem spreading depolarization and cortical dynamics during fatal seizures in Cacna1a S218L mice

(2018) Inge C M Loonen et al.   BRAIN

Paths to successful translation of new therapies for severe TBI in the golden age of traumatic brain injury research: A Pittsburgh vision

(2018) Patrick M. Kochanek et al.   JOURNAL OF NEUROTRAUMA

Excitotoxicity therapy for stroke patients still alive

(2018) Maria Domercq et al.   EBioMedicine

Exploitation of the spreading depolarization-induced cytotoxic edema for high-resolution, 3D mapping of its heterogeneous propagation paths

(2017) Jens P. Dreier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sedation of Patients with Acute Aneurysmal Subarachnoid Hemorrhage with Ketamine Is Safe and Might Influence the Occurrence of Cerebral Infarctions Associated with Delayed Cerebral Ischemia

(2017) Christian Von der brelie et al.   World Neurosurgery

Ceftriaxone- and N-acetylcysteine-induced brain tolerance to ischemia: Influence on glutamate levels in focal cerebral ischemia

(2017) Weronika Krzyżanowska et al.   PLoS One

Glutamate excitotoxicity and Ca 2+ -regulation of respiration: Role of the Ca 2+ activated mitochondrial transporters (CaMCs)

(2016) Carlos B. Rueda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Defective glutamate and K+clearance by cortical astrocytes in familial hemiplegic migraine type 2

(2016) Clizia Capuani et al.   EMBO Molecular Medicine

Ketamine modulation of the haemodynamic response to spreading depolarization in the gyrencephalic swine brain

(2016) Renán Sánchez-Porras et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Incidence, hemodynamic, and electrical characteristics of spreading depolarization in a swine model are affected by local but not by intravenous application of magnesium

(2016) Edgar Santos et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

(2016) Jens P Dreier et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Complications in Aneurysmal Subarachnoid Hemorrhage Patients With and Without Subdural Electrode Strip for Electrocorticography

(2016) Christoph Drenckhahn et al.   JOURNAL OF CLINICAL NEUROPHYSIOLOGY

Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity

(2016) Nicholas L Weilinger et al.   NATURE NEUROSCIENCE

The earliest neuronal responses to hypoxia in the neocortical circuit are glutamate-dependent

(2016) Omer Revah et al.   NEUROBIOLOGY OF DISEASE

The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema

(2015) Ravi L. Rungta et al.   CELL

Dynamics of Ionic Shifts in Cortical Spreading Depression

(2015) Rune Enger et al.   CEREBRAL CORTEX

Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions

(2015) Jason M. Hinzman et al.   EXPERIMENTAL NEUROLOGY

Intervention for Acute Stroke—Reply

(2015) Shyam Prabhakaran et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Chloride Cotransporters as a Molecular Mechanism underlying Spreading Depolarization-Induced Dendritic Beading

(2015) A. B. Steffensen et al.   JOURNAL OF NEUROSCIENCE

Supply-Demand Mismatch Transients in Susceptible Peri-infarct Hot Zones Explain the Origins of Spreading Injury Depolarizations

(2015) Daniel von Bornstädt et al.   NEURON

The Stroke-Migraine Depolarization Continuum

(2015) Jens P. Dreier et al.   NEURON

Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases

(2015) Howard Prentice et al.   Oxidative Medicine and Cellular Longevity

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma

(2014) Jason M. Hinzman et al.   BRAIN

Imaging Reveals the Focal Area of Spreading Depolarizations and a Variety of Hemodynamic Responses in a Rat Microembolic Stroke Model

(2014) Zsófia Bere et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage

(2014) Federico N. Soria et al.   JOURNAL OF CLINICAL INVESTIGATION

Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations

(2014) Daniela Pietrobon et al.   NATURE REVIEWS NEUROSCIENCE

Brainstem Neurons Survive the Identical Ischemic Stress That Kills Higher Neurons: Insight to the Persistent Vegetative State

(2014) C. Devin Brisson et al.   PLoS One

Neuropathogenesis of Delirium: Review of Current Etiologic Theories and Common Pathways

(2013) José R. Maldonado   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Regenerative Glutamate Release by Presynaptic NMDA Receptors Contributes to Spreading Depression

(2013) Ning Zhou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Propagation of cortical spreading depolarization in the human cortex after malignant stroke

(2013) J. Woitzik et al.   NEUROLOGY

Ischemia-induced depolarizations and associated hemodynamic responses in incomplete global forebrain ischemia in rats

(2013) Z. Bere et al.   NEUROSCIENCE

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Effect of analgesics and sedatives on the occurrence of spreading depolarizations accompanying acute brain injury

(2012) D. N. Hertle et al.   BRAIN

Examining protection from anoxic depolarization by the drugs dibucaine and carbetapentane using whole cell recording from CA1 neurons

(2012) Sean H. White et al.   JOURNAL OF NEUROPHYSIOLOGY

Is Spreading Depolarization Characterized by an Abrupt, Massive Release of Gibbs Free Energy from the Human Brain Cortex?

(2012) Jens P. Dreier et al.   NEUROSCIENTIST

Clusters of Spreading Depolarizations Are Associated With Disturbed Cerebral Metabolism in Patients With Aneurysmal Subarachnoid Hemorrhage

(2012) Oliver W. Sakowitz et al.   STROKE

Potent inhibition of anoxic depolarization by the sodium channel blocker dibucaine

(2011) Heather A. Douglas et al.   JOURNAL OF NEUROPHYSIOLOGY

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Dibucaine Mitigates Spreading Depolarization in Human Neocortical Slices and Prevents Acute Dendritic Injury in the Ischemic Rodent Neocortex

(2011) W. Christopher Risher et al.   PLoS One

The role of pannexin hemichannels in the anoxic depolarization of hippocampal pyramidal cells

(2010) Christian Madry et al.   BRAIN

Glutamate-Mediated Injury in Focal Cerebral Ischemia: The Excitotoxin Hypothesis Revised

(2010) Konstantin-Alexander Hossmann   BRAIN PATHOLOGY

Transient Swelling, Acidification, and Mitochondrial Depolarization Occurs in Neurons but not Astrocytes during Spreading Depression

(2010) Ning Zhou et al.   CEREBRAL CORTEX

Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury

(2010) Martin Lauritzen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Recurrent Spontaneous Spreading Depolarizations Facilitate Acute Dendritic Injury in the Ischemic Penumbra

(2010) W. C. Risher et al.   JOURNAL OF NEUROSCIENCE

Role of extracellular glutamate measured by cerebral microdialysis in severe traumatic brain injury

(2010) Roukoz Chamoun et al.   JOURNAL OF NEUROSURGERY

Microemboli may link spreading depression, migraine aura, and patent foramen ovale

(2009) Ala Nozari et al.   ANNALS OF NEUROLOGY

Recurrent spreading depolarizations after subarachnoid hemorrhage decreases oxygen availability in human cerebral cortex

(2009) Bert Bosche et al.   ANNALS OF NEUROLOGY

Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage

(2009) J. P. Dreier et al.   BRAIN

Constitutive Reactive Oxygen Species Generation from Autophagosome/Lysosome in Neuronal Oxidative Toxicity

(2009) Chisato Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two-Photon Imaging of Stroke Onset In Vivo Reveals That NMDA-Receptor Independent Ischemic Depolarization Is the Major Cause of Rapid Reversible Damage to Dendrites and Spines

(2008) T. H. Murphy et al.   JOURNAL OF NEUROSCIENCE

Zn2+ Influx Is Critical for Some Forms of Spreading Depression in Brain Slices

(2008) R. M. Dietz et al.   JOURNAL OF NEUROSCIENCE