Toward a Glutamate Hypothesis of Frontotemporal Dementia

Clinical and Biomarker Changes in Presymptomatic Genetic Frontotemporal Dementia

(2019) Alberto Benussi et al.   NEUROBIOLOGY OF AGING

Reorganization of cortical oscillatory dynamics underlying disinhibition in frontotemporal dementia

(2018) Laura E Hughes et al.   BRAIN

Neurotransmitter deficits from frontotemporal lobar degeneration

(2018) Alexander G Murley et al.   BRAIN

Discrimination of atypical parkinsonisms with transcranial magnetic stimulation

(2018) Alberto Benussi et al.   Brain Stimulation

Autoimmunity and Frontotemporal Dementia

(2018) Antonella Alberici et al.   Current Alzheimer Research

Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin

(2018) Barbara Borroni et al.   JOURNAL OF ALZHEIMERS DISEASE

Diagnosis of Mild Cognitive Impairment Due to Alzheimer’s Disease with Transcranial Magnetic Stimulation

(2018) Alessandro Padovani et al.   JOURNAL OF ALZHEIMERS DISEASE

Genotype–phenotype links in frontotemporal lobar degeneration

(2018) Sara Van Mossevelde et al.   Nature Reviews Neurology

Antibody-Mediated Encephalitis

(2018) Josep Dalmau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Memantine in Behavioral Variant Frontotemporal Dementia: Negative Results

(2018) Martine Vercelletto et al.   JOURNAL OF ALZHEIMERS DISEASE

The impact of transcranial magnetic stimulation on diagnostic confidence in patients with Alzheimer disease

(2018) Alberto Benussi et al.   Alzheimers Research & Therapy

Antinuclear antibodies in Frontotemporal Dementia: the tip's of autoimmunity iceberg?

(2018) I. Cavazzana et al.   JOURNAL OF NEUROIMMUNOLOGY

Imbalance of cortical facilitatory and inhibitory circuits underlies hyperexcitability in ALS

(2018) Mehdi A.J. Van den Bos et al.   NEUROLOGY

Review: Neuropathology of non-tau frontotemporal lobar degeneration

(2018) M. Neumann et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Depletion of Progranulin Reduces GluN2B-Containing NMDA Receptor Density, Tau Phosphorylation, and Dendritic Arborization in Mouse Primary Cortical Neurons

(2017) Francesca Longhena et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Transcranial magnetic stimulation distinguishes Alzheimer disease from frontotemporal dementia

(2017) Alberto Benussi et al.   NEUROLOGY

Anti-AMPA GluA3 antibodies in Frontotemporal dementia: a new molecular target

(2017) B. Borroni et al.   Scientific Reports

Synaptic plasticity through activation of GluA3-containing AMPA-receptors

(2017) Maria C Renner et al.   eLife

Impaired long-term potentiation-like cortical plasticity in presymptomatic genetic frontotemporal dementia

(2016) Alberto Benussi et al.   ANNALS OF NEUROLOGY

The Tau/A152T mutation, a risk factor for frontotemporal‐spectrum disorders, leads to NR2B receptor‐mediated excitotoxicity

(2016) Jochen Martin Decker et al.   EMBO REPORTS

Brain Serotonergic and Noradrenergic Deficiencies in Behavioral Variant Frontotemporal Dementia Compared to Early-Onset Alzheimer’s Disease

(2016) Yannick Vermeiren et al.   JOURNAL OF ALZHEIMERS DISEASE

Therapy and clinical trials in frontotemporal dementia: past, present, and future

(2016) Richard M. Tsai et al.   JOURNAL OF NEUROCHEMISTRY

The frontotemporal dementia-motor neuron disease continuum

(2016) James R Burrell et al.   LANCET

Characterization of Glutamatergic and GABAA-Mediated Neurotransmission in Motor and Dorsolateral Prefrontal Cortex Using Paired-Pulse TMS–EEG

(2016) Robin F H Cash et al.   NEUROPSYCHOPHARMACOLOGY

Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

(2015) Cyril Pottier et al.   ACTA NEUROPATHOLOGICA

Improving response inhibition systems in frontotemporal dementia with citalopram

(2015) Laura E. Hughes et al.   BRAIN

In vivo characterization of metabotropic glutamate receptor type 5 abnormalities in behavioral variant FTD

(2015) Antoine Leuzy et al.   Brain Structure & Function

The function of RNA-binding proteins at the synapse: implications for neurodegeneration

(2015) Chantelle F. Sephton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee

(2015) P.M. Rossini et al.   CLINICAL NEUROPHYSIOLOGY

TMS and drugs revisited 2014

(2015) Ulf Ziemann et al.   CLINICAL NEUROPHYSIOLOGY

Activation of Group I and Group II Metabotropic Glutamate Receptors Causes LTD and LTP of Electrical Synapses in the Rat Thalamic Reticular Nucleus

(2015) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

Frontotemporal dementia

(2015) Jee Bang et al.   LANCET

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

Loss ofTBK1is a frequent cause of frontotemporal dementia in a Belgian cohort

(2015) Ilse Gijselinck et al.   NEUROLOGY

Clinicopathological description of two cases withSQSTM1gene mutation associated with frontotemporal dementia

(2015) Gabor G. Kovacs et al.   NEUROPATHOLOGY

FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization

(2015) Tsuyoshi Udagawa et al.   Nature Communications

Phenotypic Heterogeneity of Monogenic Frontotemporal Dementia

(2015) Alberto Benussi et al.   Frontiers in Aging Neuroscience

Cortical Function in Asymptomatic Carriers and Patients WithC9orf72Amyotrophic Lateral Sclerosis

(2015) Nimeshan Geevasinga et al.   JAMA Neurology

Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration

(2014) Julie van der Zee et al.   ACTA NEUROPATHOLOGICA

The Glutamate Hypothesis in ALS: Pathophysiology and Drug Development

(2014) H. Blasco et al.   CURRENT MEDICINAL CHEMISTRY

Tau-Mediated NMDA Receptor Impairment Underlies Dysfunction of a Selectively Vulnerable Network in a Mouse Model of Frontotemporal Dementia

(2014) Brian A. Warmus et al.   JOURNAL OF NEUROSCIENCE

A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study

(2014) Lidia Sabater et al.   LANCET NEUROLOGY

Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia

(2014) Eduardo Gascon et al.   NATURE MEDICINE

Csf p-tau181/tau ratio as biomarker for TDP pathology in frontotemporal dementia

(2014) Barbara Borroni et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

The molecular link between inefficient GluA2 Q/R site-RNA editing and TDP-43 pathology in motor neurons of sporadic amyotrophic lateral sclerosis patients

(2013) Takenari Yamashita et al.   BRAIN RESEARCH

Allosteric Modulators for the Treatment of Schizophrenia: Targeting Glutamatergic Networks

(2013) Frank S. Menniti et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial

(2013) Adam L Boxer et al.   LANCET NEUROLOGY

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

A new algorithm for molecular diagnostics in FTLD

(2013) Barbara Borroni et al.   Nature Reviews Neurology

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Glutamatergic correlates of gamma-band oscillatory activity during cognition: A concurrent ER-MRS and EEG study

(2013) Níall Lally et al.   NEUROIMAGE

Criteria for the diagnosis of corticobasal degeneration

(2013) M. J. Armstrong et al.   NEUROLOGY

AMPARs and Synaptic Plasticity: The Last 25 Years

(2013) Richard L. Huganir et al.   NEURON

Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

(2013) Amy M Pooler et al.   Alzheimers Research & Therapy

SQSTM1Mutations in French Patients With Frontotemporal Dementia or Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

(2013) Isabelle Le Ber   JAMA Neurology

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments

(2013) Josien Levenga et al.   Acta Neuropathologica Communications

The genetics and neuropathology of frontotemporal lobar degeneration

(2012) Anne Sieben et al.   ACTA NEUROPATHOLOGICA

Behavioral correlates of cerebrospinal fluid amino acid and biogenic amine neurotransmitter alterations in dementia

(2012) Yannick Vermeiren et al.   Alzheimers & Dementia

GluA3-deficiency in mice is associated with increased social and aggressive behavior and elevated dopamine in striatum

(2012) Abby Adamczyk et al.   BEHAVIOURAL BRAIN RESEARCH

MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions

(2012) Juliane Lescher et al.   JOURNAL OF NEUROIMMUNOLOGY

SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2012) E. Rubino et al.   NEUROLOGY

Serotonergic Function and Treatment of Behavioral and Psychological Symptoms of Frontotemporal Dementia

(2011) Nathan Herrmann et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Motor Neuron dysfunction in frontotemporal dementia

(2011) James R. Burrell et al.   BRAIN

Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration

(2011) J. D. Rohrer et al.   BRAIN

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

(2011) Katya Rascovsky et al.   BRAIN

Classification of primary progressive aphasia and its variants

(2011) M. L. Gorno-Tempini et al.   NEUROLOGY

Glutamate Differently Modulates Metabotropic Glutamate Receptors in Neuronal and Glial Cells

(2010) Carlos Alberto Castillo et al.   NEUROCHEMICAL RESEARCH

Genetic contribution of FUS to frontotemporal lobar degeneration

(2010) T. Van Langenhove et al.   NEUROLOGY

CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin

(2010) Patricio Opazo et al.   NEURON

Absence of FUS-immunoreactive pathology in frontotemporal dementia linked to chromosome 3 (FTD-3) caused by mutation in the CHMP2B gene

(2009) Ida Elisabeth Holm et al.   ACTA NEUROPATHOLOGICA

Clinical heterogeneity in 3 unrelated families linked to VCP p.Arg159His

(2009) J. van der Zee et al.   NEUROLOGY

Ionotropic Glutamate Receptors & CNS Disorders

(2008) Derek Bowie   CNS & Neurological Disorders-Drug Targets