Striatal synaptic adaptations in Parkinson's disease

Levodopa Causes Striatal Cholinergic Interneuron Burst‐Pause Activity in Parkinsonian Mice

(2021) Rodrigo Manuel Paz et al.   MOVEMENT DISORDERS

Thalamic projections to the subthalamic nucleus contribute to movement initiation and rescue of parkinsonian symptoms

(2021) Glenn D. R. Watson et al.   Science Advances

Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia

(2021) Lauren Malave et al.   Communications Biology

Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response

(2021) Bárbara Mendes-Pinheiro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Disruption of mitochondrial complex I induces progressive parkinsonism

(2021) Patricia González-Rodríguez et al.   NATURE

CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors

(2021) Jill R. Crittenden et al.   NEUROBIOLOGY OF DISEASE

Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson’s disease

(2020) Yaping Chu et al.   BRAIN

Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA

(2020) Se Joon Choi et al.   eLife

Delayed Spine Pruning of Direct Pathway Spiny Projection Neurons in a Mouse Model of Parkinson’s Disease

(2019) Steven M. Graves et al.   Frontiers in Cellular Neuroscience

Changes in Dendritic Spine Density and Inhibitory Perisomatic Connectivity onto Medium Spiny Neurons in l-Dopa-Induced Dyskinesia

(2019) G. Gomez et al.   MOLECULAR NEUROBIOLOGY

Dopaminergic modulation of striatal function and Parkinson’s disease

(2019) Shenyu Zhai et al.   JOURNAL OF NEURAL TRANSMISSION

What, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation

(2019) Andreas Klaus et al.   Annual Review of Neuroscience

Striatal synapses, circuits, and Parkinson's disease

(2018) Shenyu Zhai et al.   CURRENT OPINION IN NEUROBIOLOGY

Differential Synaptic Remodeling by Dopamine in Direct and Indirect Striatal Projection Neurons in Pitx3−/−Mice, a Genetic Model of Parkinson's Disease

(2018) Luz M. Suarez et al.   JOURNAL OF NEUROSCIENCE

What does dopamine mean?

(2018) Joshua D. Berke   NATURE NEUROSCIENCE

A Subpopulation of Striatal Neurons Mediates Levodopa-Induced Dyskinesia

(2018) Allison E. Girasole et al.   NEURON

Striatonigral neurons divide into two distinct morphological-physiological phenotypes after chronic L-DOPA treatment in parkinsonian rats

(2018) T. Fieblinger et al.   Scientific Reports

Diametric neural ensemble dynamics in parkinsonian and dyskinetic states

(2018) Jones G. Parker et al.   NATURE

Heterogeneity and Diversity of Striatal GABAergic Interneurons: Update 2018

(2018) James M. Tepper et al.   Frontiers in Neuroanatomy

Learning new sequential stepping patterns requires striatal plasticity during the earliest phase of acquisition

(2017) Toru Nakamura et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chemogenetic stimulation of striatal projection neurons modulates responses to Parkinson’s disease therapy

(2017) Cristina Alcacer et al.   JOURNAL OF CLINICAL INVESTIGATION

Motor learning in animal models of Parkinson's disease: Aberrant synaptic plasticity in the motor cortex

(2017) Tonghui Xu et al.   MOVEMENT DISORDERS

Striatal D1 medium spiny neuron activation induces dyskinesias in parkinsonian mice

(2017) Xiomara A. Perez et al.   MOVEMENT DISORDERS

Cell-type–specific inhibition of the dendritic plateau potential in striatal spiny projection neurons

(2017) Kai Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice

(2017) D. Gagnon et al.   Scientific Reports

Complementary Contributions of Striatal Projection Pathways to Action Initiation and Execution

(2016) Fatuel Tecuapetla et al.   CELL

L-DOPA Oppositely Regulates Synaptic Strength and Spine Morphology in D1 and D2 Striatal Projection Neurons in Dyskinesia

(2016) Luz M Suarez et al.   CEREBRAL CORTEX

Loss of Homeostasis in the Direct Pathway in a Mouse Model of Asymptomatic Parkinson's Disease

(2016) M. V. Escande et al.   JOURNAL OF NEUROSCIENCE

Rapid signalling in distinct dopaminergic axons during locomotion and reward

(2016) M. W. Howe et al.   NATURE

Modulation of serotonergic transmission by eltoprazine in L-DOPA-induced dyskinesia: Behavioral, molecular, and synaptic mechanisms

(2016) Veronica Ghiglieri et al.   NEUROBIOLOGY OF DISEASE

Optogenetic activation of striatal cholinergic interneurons regulates L-dopa-induced dyskinesias

(2016) Tanuja Bordia et al.   NEUROBIOLOGY OF DISEASE

Spatially Compact Neural Clusters in the Dorsal Striatum Encode Locomotion Relevant Information

(2016) Giovanni Barbera et al.   NEURON

Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice

(2016) Philip R.L. Parker et al.   NEURON

Pathway-Specific Striatal Substrates for Habitual Behavior

(2016) Justin K. O’Hare et al.   NEURON

Mutual Control of Cholinergic and Low-Threshold Spike Interneurons in the Striatum

(2016) Rasha Elghaba et al.   Frontiers in Cellular Neuroscience

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

(2016) Ozgun Gokce et al.   Cell Reports

Decrease of a Current Mediated by K v 1.3 Channels Causes Striatal Cholinergic Interneuron Hyperexcitability in Experimental Parkinsonism

(2016) Cecilia Tubert et al.   Cell Reports

Retrograde Axonal Degeneration in Parkinson Disease

(2016) Patricia Tagliaferro et al.   Journal of Parkinsons Disease

Phasic Dopamine Modifies Sensory-Driven Output of Striatal Neurons through Synaptic Plasticity

(2015) S. Wieland et al.   JOURNAL OF NEUROSCIENCE

Amantadine extended release for levodopa-induced dyskinesia in Parkinson's disease (EASED Study)

(2015) Rajesh Pahwa et al.   MOVEMENT DISORDERS

Enhanced histamine H2 excitation of striatal cholinergic interneurons in l-DOPA-induced dyskinesia

(2015) Sean Austin O. Lim et al.   NEUROBIOLOGY OF DISEASE

Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3−/− aphakia mice

(2015) Oscar Solís et al.   NEUROBIOLOGY OF DISEASE

Cell-Type-Specific Sensorimotor Processing in Striatal Projection Neurons during Goal-Directed Behavior

(2015) Tanya Sippy et al.   NEURON

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia

(2015) Weixing Shen et al.   NEURON

Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice

(2015) Anders Borgkvist et al.   NEURON

Evidence for a role for α6∗ nAChRs in l-dopa-induced dyskinesias using parkinsonian α6∗ nAChR gain-of-function mice

(2015) T. Bordia et al.   NEUROSCIENCE

Changes in the expression of neurotransmitter receptors in Parkin and DJ-1 knockout mice – A quantitative multireceptor study

(2015) J.N. Cremer et al.   NEUROSCIENCE

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

(2015) Matthieu F. Bastide et al.   PROGRESS IN NEUROBIOLOGY

Alterations in neuronal activity in basal ganglia-thalamocortical circuits in the parkinsonian state

(2015) Adriana Galvan et al.   Frontiers in Neuroanatomy

Optogenetic stimulation reveals distinct modulatory properties of thalamostriatal vs corticostriatal glutamatergic inputs to fast-spiking interneurons

(2015) Giuseppe Sciamanna et al.   Scientific Reports

Coordinated Regulation of Synaptic Plasticity at Striatopallidal and Striatonigral Neurons Orchestrates Motor Control

(2015) Massimo Trusel et al.   Cell Reports

Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses

(2015) Igor V. Rafalovich et al.   Cell Reports

Striatal Cholinergic Interneurons Control Motor Behavior and Basal Ganglia Function in Experimental Parkinsonism

(2015) Nicolas Maurice et al.   Cell Reports

Input- and Cell-Type-Specific Endocannabinoid-Dependent LTD in the Striatum

(2015) Yu-Wei Wu et al.   Cell Reports

Reassessing Models of Basal Ganglia Function and Dysfunction

(2014) Alexandra B. Nelson et al.   Annual Review of Neuroscience

Dopaminergic modulation of striatal networks in health and Parkinson's disease

(2014) D James Surmeier et al.   CURRENT OPINION IN NEUROBIOLOGY

Three Mechanisms by which Striatal Denervation Causes Breakdown of Dopamine Signaling

(2014) J. K. Dreyer   JOURNAL OF NEUROSCIENCE

Striatal Cholinergic Cell Ablation Attenuates L-DOPA Induced Dyskinesia in Parkinsonian Mice

(2014) L. Won et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Ser1166 on GluN2B by PKA Is Critical to Synaptic NMDA Receptor Function and Ca 2+ Signaling in Spines

(2014) Jessica A. Murphy et al.   JOURNAL OF NEUROSCIENCE

Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model

(2014) Haruo Nishijima et al.   MOVEMENT DISORDERS

Multisensory Integration in the Mouse Striatum

(2014) Ramon Reig et al.   NEURON

Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease

(2014) Joshua L. Plotkin et al.   NEURON

Phasic Dopamine Release Drives Rapid Activation of Striatal D2-Receptors

(2014) Pamela F. Marcott et al.   NEURON

Nitric oxide regulates synaptic transmission between spiny projection neurons

(2014) Yotam Sagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical time window for dopamine actions on the structural plasticity of dendritic spines

(2014) S. Yagishita et al.   SCIENCE

Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states

(2014) Katerina D. Oikonomou et al.   Frontiers in Cellular Neuroscience

Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia

(2014) Tim Fieblinger et al.   Nature Communications

Active Properties of Neocortical Pyramidal Neuron Dendrites

(2013) Guy Major et al.   Annual Review of Neuroscience

Multiple CNS nicotinic receptors mediate l-dopa-induced dyskinesias: Studies with parkinsonian nicotinic receptor knockout mice

(2013) Maryka Quik et al.   BIOCHEMICAL PHARMACOLOGY

L-DOPA Treatment Selectively Restores Spine Density in Dopamine Receptor D2–Expressing Projection Neurons in Dyskinetic Mice

(2013) Luz M. Suárez et al.   BIOLOGICAL PSYCHIATRY

Neuronal loss in the caudal intralaminar thalamic nuclei in a primate model of Parkinson’s disease

(2013) R. M. Villalba et al.   Brain Structure & Function

Selective Effects of Dopamine Depletion and L-DOPA Therapy on Learning-Related Firing Dynamics of Striatal Neurons

(2013) L. F. Hernandez et al.   JOURNAL OF NEUROSCIENCE

Concurrent activation of striatal direct and indirect pathways during action initiation

(2013) Guohong Cui et al.   NATURE

Corticostriatal connectivity and its role in disease

(2013) Gordon M. G. Shepherd   NATURE REVIEWS NEUROSCIENCE

Differential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons

(2013) Nicholas R. Wall et al.   NEURON

α4β2 nicotinic receptors play a role in the nAChR-mediated decline in l-dopa-induced dyskinesias in parkinsonian rats

(2013) Maryka Quik et al.   NEUROPHARMACOLOGY

Heterogeneous properties of central lateral and parafascicular thalamic synapses in the striatum

(2012) T. J. Ellender et al.   JOURNAL OF PHYSIOLOGY-LONDON

RGS4 Is Required for Dopaminergic Control of Striatal LTD and Susceptibility to Parkinsonian Motor Deficits

(2012) Talia N. Lerner et al.   NEURON

Thalamic Contributions to Basal Ganglia-Related Behavioral Switching and Reinforcement

(2011) Y. Smith et al.   JOURNAL OF NEUROSCIENCE

Synaptically driven state transitions in distal dendrites of striatal spiny neurons

(2011) Joshua L Plotkin et al.   NATURE NEUROSCIENCE

Dendritic Spines and Distributed Circuits

(2011) Rafael Yuste   NEURON

Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function

(2011) G. Turrigiano   Cold Spring Harbor Perspectives in Biology

Basal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments

(2011) Jill R. Crittenden et al.   Frontiers in Neuroanatomy

L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission

(2011) Michael Feyder et al.   Frontiers in Behavioral Neuroscience

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia

(2010) Barbara Picconi et al.   BRAIN

Primary Motor Cortex of the Parkinsonian Monkey: Differential Effects on the Spontaneous Activity of Pyramidal Tract-Type Neurons

(2010) Benjamin Pasquereau et al.   CEREBRAL CORTEX

A Subpopulation of Neuronal M4 Muscarinic Acetylcholine Receptors Plays a Critical Role in Modulating Dopamine-Dependent Behaviors

(2010) J. Jeon et al.   JOURNAL OF NEUROSCIENCE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors

(2010) Michael J Higley et al.   NATURE NEUROSCIENCE

Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in parkinsonian mice

(2010) Y. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscarinic Inhibition of Hippocampal and Striatal Adenylyl Cyclase is Mainly Due to the M4 Receptor

(2009) Gonzalo Sánchez et al.   NEUROCHEMICAL RESEARCH

The MitoPark Mouse – An animal model of Parkinson's disease with impaired respiratory chain function in dopamine neurons

(2009) Mats I. Ekstrand et al.   PARKINSONISM & RELATED DISORDERS

Impact of dopamine–glutamate interactions on striatal neuronal nitric oxide synthase activity

(2009) Kristina E. Hoque et al.   PSYCHOPHARMACOLOGY

Habits, Rituals, and the Evaluative Brain

(2008) Ann M. Graybiel   Annual Review of Neuroscience

Antagonizing L-type Ca2+ Channel Reduces Development of Abnormal Involuntary Movement in the Rat Model of L-3,4-Dihydroxyphenylalanine-Induced Dyskinesia

(2008) Stefan Schuster et al.   BIOLOGICAL PSYCHIATRY

Lowered cAMP and cGMP signalling in the brain during levodopa-induced dyskinesias in hemiparkinsonian rats: new aspects in the pathogenetic mechanisms

(2008) M. Giorgi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dopaminergic denervation and spine loss in the striatum of MPTP-treated monkeys

(2008) Rosa M. Villalba et al.   EXPERIMENTAL NEUROLOGY

Spatiotemporally Graded NMDA Spike/Plateau Potentials in Basal Dendrites of Neocortical Pyramidal Neurons

(2008) Guy Major et al.   JOURNAL OF NEUROPHYSIOLOGY

Differential Excitability and Modulation of Striatal Medium Spiny Neuron Dendrites

(2008) M. Day et al.   JOURNAL OF NEUROSCIENCE

Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons

(2008) T. S. Gertler et al.   JOURNAL OF NEUROSCIENCE

Compartmentalized dendritic plasticity and input feature storage in neurons

(2008) Attila Losonczy et al.   NATURE

Pyramidal neurons: dendritic structure and synaptic integration

(2008) Nelson Spruston   NATURE REVIEWS NEUROSCIENCE

Molecular mechanisms of L-DOPA-induced dyskinesia

(2008) Peter Jenner   NATURE REVIEWS NEUROSCIENCE

Striatal Plasticity and Basal Ganglia Circuit Function

(2008) Anatol C. Kreitzer et al.   NEURON

Dendritic Excitability and Synaptic Plasticity

(2008) P. Jesper Sjöström et al.   PHYSIOLOGICAL REVIEWS

Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity

(2008) W. Shen et al.   SCIENCE