CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors

Integration of Rap1 and Calcium Signaling

(2020) Ramoji Kosuru et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Striatal Kir2 K+ channel inhibition mediates the antidyskinetic effects of amantadine

(2020) Weixing Shen et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of muscarinic M1 receptor stimulation on reinforcing and neurochemical effects of cocaine in rats

(2020) Pia Weikop et al.   NEUROPSYCHOPHARMACOLOGY

Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies

(2020) Daniel Dautan et al.   Nature Communications

Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons

(2020) Rebekah C. Evans et al.   Cell Reports

Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons

(2019) Luis Carrillo-Reid et al.   eLife

What, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation

(2019) Andreas Klaus et al.   Annual Review of Neuroscience

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

(2019) Bryan Zeitler et al.   NATURE MEDICINE

Subcellular localization of Rap1 GTPase activator CalDAG‐GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides

(2019) Muzaddid Sarker et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Functionally Distinct Connectivity of Developmentally Targeted Striosome Neurons

(2019) Matthew M. McGregor et al.   Cell Reports

Inversely Active Striatal Projection Neurons and Interneurons Selectively Delimit Useful Behavioral Sequences

(2018) Nuné Martiros et al.   CURRENT BIOLOGY

Striatal synapses, circuits, and Parkinson's disease

(2018) Shenyu Zhai et al.   CURRENT OPINION IN NEUROBIOLOGY

Dual Dopaminergic Regulation of Corticostriatal Plasticity by Cholinergic Interneurons and Indirect Pathway Medium Spiny Neurons

(2018) Shana M. Augustin et al.   Cell Reports

Learning new sequential stepping patterns requires striatal plasticity during the earliest phase of acquisition

(2017) Toru Nakamura et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chemogenetic stimulation of striatal projection neurons modulates responses to Parkinson’s disease therapy

(2017) Cristina Alcacer et al.   JOURNAL OF CLINICAL INVESTIGATION

Vesicular acetylcholine transporter (VAChT) over-expression induces major modifications of striatal cholinergic interneuron morphology and function

(2017) Helena Janickova et al.   JOURNAL OF NEUROCHEMISTRY

M 1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons

(2017) Xiaohui Lv et al.   NEUROPHARMACOLOGY

Effects of muscarinic M1 and M4 acetylcholine receptor stimulation on extinction and reinstatement of cocaine seeking in male mice, independent of extinction learning

(2017) Kevin Stoll et al.   PSYCHOPHARMACOLOGY

Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking

(2016) Jasper A. Heinsbroek et al.   JOURNAL OF NEUROSCIENCE

Striosome–dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons

(2016) Jill R. Crittenden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine Is Required for the Neural Representation and Control of Movement Vigor

(2015) Babita Panigrahi et al.   CELL

Corticostriatal synaptic adaptations in Huntington's disease

(2015) Joshua L Plotkin et al.   CURRENT OPINION IN NEUROBIOLOGY

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia

(2015) Weixing Shen et al.   NEURON

Modulation of direct pathway striatal projection neurons by muscarinic M4-type receptors

(2015) Teresa Hernández-Flores et al.   NEUROPHARMACOLOGY

Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome

(2015) Meiyu Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens

(2015) Jung Hoon Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Striatum: Where Skills and Habits Meet

(2015) Ann M. Graybiel et al.   Cold Spring Harbor Perspectives in Biology

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

(2014) Matthias Canault et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Major External Source of Cholinergic Innervation of the Striatum and Nucleus Accumbens Originates in the Brainstem

(2014) D. Dautan et al.   JOURNAL OF NEUROSCIENCE

Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease

(2014) Joshua L. Plotkin et al.   NEURON

Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance

(2014) Christiane Schreiweis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe drug-induced repetitive behaviors and striatal overexpression of VAChT in ChAT-ChR2-EYFP BAC transgenic mice

(2014) Jill R. Crittenden et al.   Frontiers in Neural Circuits

The Thalamostriatal Pathway and Cholinergic Control of Goal-Directed Action: Interlacing New with Existing Learning in the Striatum

(2013) Laura A. Bradfield et al.   NEURON

Inactivation of muscarinic receptors impairs place and response learning: Implications for multiple memory systems

(2013) Juliana Carlota Kramer Soares et al.   NEUROPHARMACOLOGY

Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats

(2012) Amanda A. Braun et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

(2012) Mitsuko Watabe-Uchida et al.   NEURON

Modulation of Striatal Projection Systems by Dopamine

(2011) Charles R. Gerfen et al.   Annual Review of Neuroscience

Rap1-Rac1 Circuits Potentiate Platelet Activation

(2011) Lucia Stefanini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cholinergic modulation of synaptic integration and dendritic excitability in the striatum

(2011) Ian Antón Oldenburg et al.   CURRENT OPINION IN NEUROBIOLOGY

Reduced striatal acetylcholine efflux in the R6/2 mouse model of Huntington's disease: An examination of the role of altered inhibitory and excitatory mechanisms

(2011) Andrew M. Farrar et al.   EXPERIMENTAL NEUROLOGY

A novel instrumented multipeg running wheel system, Step-Wheel, for monitoring and controlling complex sequential stepping in mice

(2011) Takashi Kitsukawa et al.   JOURNAL OF NEUROPHYSIOLOGY

Contributions of dorsal striatal subregions to spatial alternation behavior

(2011) R. Moussa et al.   LEARNING & MEMORY

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

Contribution of both M1 and M4 receptors to muscarinic agonist-mediated attenuation of the cocaine discriminative stimulus in mice

(2011) Morgane Thomsen et al.   PSYCHOPHARMACOLOGY

Key role of striatal cholinergic interneurons in processes leading to arrest of motor stereotypies

(2010) Verena Aliane et al.   BRAIN

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease

(2010) Jill R. Crittenden et al.   HUMAN MOLECULAR GENETICS

CalDAG-GEFI and platelet activation

(2010) Lucia Stefanini et al.   PLATELETS

Discovery and Characterization of Novel Subtype-Selective Allosteric Agonists for the Investigation of M1 Receptor Function in the Central Nervous System

(2009) Evan P Lebois et al.   ACS Chemical Neuroscience

Attenuation of Cocaine's Reinforcing and Discriminative Stimulus Effects via Muscarinic M1 Acetylcholine Receptor Stimulation

(2009) M. Thomsen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning

(2009) D. J. Sheffler et al.   MOLECULAR PHARMACOLOGY

Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy

(2009) Jill R. Crittenden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety

(2009) Alexia Thomas et al.   PSYCHOPHARMACOLOGY

Differential Excitability and Modulation of Striatal Medium Spiny Neuron Dendrites

(2008) M. Day et al.   JOURNAL OF NEUROSCIENCE

Recurrent Collateral Connections of Striatal Medium Spiny Neurons Are Disrupted in Models of Parkinson's Disease

(2008) S. Taverna et al.   JOURNAL OF NEUROSCIENCE

Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons

(2008) T. S. Gertler et al.   JOURNAL OF NEUROSCIENCE

Striatal Plasticity and Basal Ganglia Circuit Function

(2008) Anatol C. Kreitzer et al.   NEURON

Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity

(2008) W. Shen et al.   SCIENCE

Differential involvement of M1-type and M4-type muscarinic cholinergic receptors in the dorsomedial striatum in task switching

(2007) Martha F. McCool et al.   NEUROBIOLOGY OF LEARNING AND MEMORY