Engineered cellular immunotherapies in cancer and beyond

Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

(2022) J. Joseph Melenhorst et al.   NATURE

CAR T cells produced in vivo to treat cardiac injury

(2022) Joel G. Rurik et al.   SCIENCE

Current Concepts and Advances in Graft-Versus-Host Disease Immunology

(2021) Geoffrey R. Hill et al.   Annual Review of Immunology

Immune Biology of Acute Myeloid Leukemia: Implications for Immunotherapy

(2021) Sophia Khaldoyanidi et al.   JOURNAL OF CLINICAL ONCOLOGY

A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

(2021) Shoichi Iriguchi et al.   Nature Communications

Will allogeneic CAR T cells for CD19+ malignancies take autologous CAR T cells ‘off the shelf’?

(2021) Amanda M. DiNofia et al.   Nature Reviews Clinical Oncology

Genetic engineering of T cells for immunotherapy

(2021) Gavin I. Ellis et al.   NATURE REVIEWS GENETICS

Chimeric antigen receptor T-cell therapy for HIV cure

(2021) Oscar Alfageme-Abello et al.   Current Opinion in HIV and AIDS

Investigation of product derived lymphoma following infusion of piggyBac modified CD19 chimeric antigen receptor T-cells

(2021) Kenneth Paul Micklethwaite et al.   BLOOD

The microbiome and human cancer

(2021) Gregory D. Sepich-Poore et al.   SCIENCE

Synthetic Lethality in Cancer Therapeutics: The Next Generation

(2021) Jeremy Setton et al.   Cancer Discovery

Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy

(2021) Ramazan Rezaei et al.   CANCER GENE THERAPY

Immune Cells and Immunotherapy for Cardiac Injury and Repair

(2021) Joel G. Rurik et al.   CIRCULATION RESEARCH

Impact of Prior Treatment on the Efficacy of Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma

(2021) Samantha J. Seitter et al.   CLINICAL CANCER RESEARCH

CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus

(2021) Dimitrios Mougiakakos et al.   NEW ENGLAND JOURNAL OF MEDICINE

AAV-mediated in vivo CAR gene therapy for targeting human T-cell leukemia

(2021) Waqas Nawaz et al.   Blood Cancer Journal

A phase I trial of regional mesothelin-targeted CAR T-cell therapy in patients with malignant pleural disease, in combination with the anti-PD-1 agent pembrolizumab

(2021) Prasad S Adusumilli et al.   Cancer Discovery

Real-World Experiences of CAR T-Cell Therapy for Large B-Cell Lymphoma: How Similar Are They to the Prospective Studies?

(2021) Kevin Tang et al.   Journal of Immunotherapy and Precision Oncology

Charting the tumor antigen maps drawn by single-cell genomics

(2021) Caleb A. Lareau et al.   CANCER CELL

An NK-like CAR T cell transition in CAR T cell dysfunction

(2021) Charly R. Good et al.   CELL

Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

(2021) Mark Yarmarkovich et al.   NATURE

Off-the-shelf, gene-edited CAR-T cells forge ahead, despite safety scare

(2021) Cormac Sheridan   NATURE BIOTECHNOLOGY

Neurocognitive and hypokinetic movement disorder with features of parkinsonism after BCMA-targeting CAR-T cell therapy

(2021) Oliver Van Oekelen et al.   NATURE MEDICINE

Immune and Genome Engineering as the Future of Transplantable Tissue

(2021) Jennifer Elisseeff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Induced Pluripotent Stem Cell-Derived Macrophages Ameliorate Liver Fibrosis

(2021) Somayeh Pouyanfard et al.   STEM CELLS

Current development in adenoviral vectors for cancer immunotherapy

(2021) Greyson Willis Grossman Biegert et al.   Molecular Therapy-Oncolytics

‘Off-the-shelf’ allogeneic CAR T cells: development and challenges

(2020) S. Depil et al.   NATURE REVIEWS DRUG DISCOVERY

Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation

(2020) Jonathan U. Peled et al.   NEW ENGLAND JOURNAL OF MEDICINE

CRISPR-engineered T cells in patients with refractory cancer

(2020) Edward A. Stadtmauer et al.   SCIENCE

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

(2020) Katharina Reinhard et al.   SCIENCE

Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T cell dysfunction

(2020) Nathan Singh et al.   Cancer Discovery

In Vivo Generation of CAR T Cells Selectively in Human CD4+ Lymphocytes

(2020) Shiwani Agarwal et al.   MOLECULAR THERAPY

Human chimeric antigen receptor macrophages for cancer immunotherapy

(2020) Michael Klichinsky et al.   NATURE BIOTECHNOLOGY

Engineering CAR-T Cells for Next-Generation Cancer Therapy

(2020) Mihe Hong et al.   CANCER CELL

Dendritic cell therapy in cancer treatment; the state-of-the-art

(2020) Mahsa Sadeghzadeh et al.   LIFE SCIENCES

Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia

(2020) Meir Rozenbaum et al.   Frontiers in Immunology

Viral Delivery of CAR Targets to Solid Tumors Enables Effective Cell Therapy

(2020) Amin Aalipour et al.   Molecular Therapy-Oncolytics

Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies

(2020) Kevin R. Parker et al.   CELL

Designed protein logic to target cells with precise combinations of surface antigens

(2020) Marc J. Lajoie et al.   SCIENCE

Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors

(2020) Anthony K. Park et al.   Science Translational Medicine

Discriminatory Power of Combinatorial Antigen Recognition in Cancer T Cell Therapies

(2020) Ruth Dannenfelser et al.   Cell Systems

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance

(2020) Sreya Bagchi et al.   Annual Review of Pathology-Mechanisms of Disease

Taming the beast: CRS and ICANS after CAR T-cell therapy for ALL

(2020) Vipul S Sheth et al.   BONE MARROW TRANSPLANTATION

Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies

(2020) Reuben Benjamin et al.   LANCET

Gene therapy using haematopoietic stem and progenitor cells

(2020) Giuliana Ferrari et al.   NATURE REVIEWS GENETICS

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

(2020) Haydar Frangoul et al.   NEW ENGLAND JOURNAL OF MEDICINE

Precise T cell recognition programs designed by transcriptionally linking multiple receptors

(2020) Jasper Z. Williams et al.   SCIENCE

The role of the intestinal microbiota in allogeneic HCT: clinical associations and preclinical mechanisms

(2020) Chi L Nguyen et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

(2019) Agnieszka Czechowicz et al.   Nature Communications

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

(2019) Takeshi Tanoue et al.   NATURE

New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion

(2019) Stefan Pellenz et al.   HUMAN GENE THERAPY

Chimeric antigen receptor–T cell therapy manufacturing: modelling the effect of offshore production on aggregate cost of goods

(2019) Richard P. Harrison et al.   CYTOTHERAPY

Manufacturing chimeric antigen receptor T cells: issues and challenges

(2019) Claire Roddie et al.   CYTOTHERAPY

Intestinal Microbiome Analyses Identify Biomarkers for Patient Response to CAR T Cell Therapy

(2019) Melody Smith et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity

(2019) Bryan D. Choi et al.   NATURE BIOTECHNOLOGY

T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant

(2019) Aude G. Chapuis et al.   NATURE MEDICINE

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

(2019) Patrick A. Baeuerle et al.   Nature Communications

Novel Targeting to XCR1+ Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes

(2019) Yusuke Kitazawa et al.   Frontiers in Immunology

Targeting cardiac fibrosis with engineered T cells

(2019) Haig Aghajanian et al.   NATURE

Clinical lessons learned from the first leg of the CAR T cell journey

(2019) Robbie G. Majzner et al.   NATURE MEDICINE

Autoimmunity as a target for chimeric immune receptor therapy: A new vision to therapeutic potential

(2019) Mohammad-Hossein Haddadi et al.   BLOOD REVIEWS

Why and where an HIV cure is needed and how it might be achieved

(2019) Thumbi Ndung’u et al.   NATURE

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

(2018) Miriam Y. Kim et al.   CELL

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

(2018) Ye Li et al.   Cell Stem Cell

Niches for Hematopoietic Stem Cells and Their Progeny

(2018) Qiaozhi Wei et al.   IMMUNITY

Visualizing the Rapid and Dynamic Elimination of Allogeneic T Cells in Secondary Lymphoid Organs

(2018) Yasuhiro Kanda et al.   JOURNAL OF IMMUNOLOGY

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

Contemporary Strategies and Barriers to Transplantation Tolerance

(2018) Brian Ezekian et al.   TRANSPLANTATION

Chimeric Antigen Receptor T Cell–Mediated Neurotoxicity in Nonhuman Primates

(2018) Agne Taraseviciute et al.   Cancer Discovery

Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus–Driven Production of a Bispecific T-cell Engager

(2018) Anna Wing et al.   Cancer Immunology Research

Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors

(2018) Vincent Yi Sheng Oei et al.   Cancer Immunology Research

Biomanufacturing for clinically advanced cell therapies

(2018) Ayesha Aijaz et al.   Nature Biomedical Engineering

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

(2018) Anett Pfeiffer et al.   EMBO Molecular Medicine

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

(2018) Sarwish Rafiq et al.   NATURE BIOTECHNOLOGY

Checkpoint blockade reverses anergy in IL13Rα2 humanized scFv based CAR T cells to treat murine and canine gliomas.

(2018) Yibo Yin et al.   Molecular Therapy-Oncolytics

ASBMT Consensus Grading for Cytokine Release Syndrome and Neurological Toxicity Associated with Immune Effector Cells

(2018) Daniel W Lee et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier

(2018) Jonathan H. Esensten et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CAR-T Cells and Oncolytic Viruses: Joining Forces to Overcome the Solid Tumor Challenge

(2018) Sonia Guedan et al.   Frontiers in Immunology

Shared cancer neoantigens: Making private matters public

(2017) Christopher A. Klebanoff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adenovirotherapy Delivering Cytokine and Checkpoint Inhibitor Augments CAR T Cells against Metastatic Head and Neck Cancer

(2017) Amanda Rosewell Shaw et al.   MOLECULAR THERAPY

Is autoimmunity the Achilles' heel of cancer immunotherapy?

(2017) Carl H June et al.   NATURE MEDICINE

The impact of antibiotic usage on the efficacy of chemoimmunotherapy is contingent on the source of tumor-reactive T cells

(2017) Michal P. Kuczma et al.   Oncotarget

CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells

(2017) Levi J. Rupp et al.   Scientific Reports

CAR T Cells Releasing IL-18 Convert to T-Bet high FoxO1 low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors

(2017) Markus Chmielewski et al.   Cell Reports

Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants

(2017) Giedre Krenciute et al.   Cancer Immunology Research

Global Manufacturing of CAR T Cell Therapy

(2017) Bruce L. Levine et al.   Molecular Therapy-Methods & Clinical Development

Prospects for combined use of oncolytic viruses and CAR T-cells

(2017) Adam Ajina et al.   Journal for ImmunoTherapy of Cancer

Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

(2016) Joseph A. Fraietta et al.   BLOOD

Immune checkpoint blockade: Releasing the brake towards hematological malignancies

(2016) Yi Xia et al.   BLOOD REVIEWS

Oncolytic virus therapy: A new era of cancer treatment at dawn

(2016) Hiroshi Fukuhara et al.   CANCER SCIENCE

Microbiome and Anticancer Immunosurveillance

(2016) Laurence Zitvogel et al.   CELL

Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition

(2016) Jiangtao Ren et al.   CLINICAL CANCER RESEARCH

Heterogeneity of the bone marrow niche

(2016) Vionnie W.C. Yu et al.   CURRENT OPINION IN HEMATOLOGY

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

(2016) Avery D. Posey et al.   IMMUNITY

Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia

(2016) Paulina J. Paszkiewicz et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

(2016) S Hipp et al.   LEUKEMIA

Adenoviral Delivery of Tumor Necrosis Factor-α and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma

(2016) Mikko Siurala et al.   MOLECULAR THERAPY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Autosomal Minor Histocompatibility Antigens: How Genetic Variants Create Diversity in Immune Targets

(2016) Marieke Griffioen et al.   Frontiers in Immunology

Allorecognition by T Lymphocytes and Allograft Rejection

(2016) Jose Marino et al.   Frontiers in Immunology

Phase I study with ONCOS-102 for the treatment of solid tumors – an evaluation of clinical response and exploratory analyses of immune markers

(2016) Tuuli Ranki et al.   Journal for ImmunoTherapy of Cancer

Complement-Binding Donor-Specific Anti-HLA Antibodies and Risk of Primary Graft Failure in Hematopoietic Stem Cell Transplantation

(2015) Stefan O. Ciurea et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Bone Marrow Cell Rejection, MHC, NK Cells, and Missing Self Recognition: Ain’t That Peculiar (with Apologies to Marvin Gaye)

(2015) David H. Raulet   JOURNAL OF IMMUNOLOGY

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

(2015) Ignazio Caruana et al.   NATURE MEDICINE

Overcoming T cell exhaustion in infection and cancer

(2015) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells

(2015) Alexander J. Davenport et al.   Cancer Immunology Research

Long-Term Safety Issues of iPSC-Based Cell Therapy in a Spinal Cord Injury Model: Oncogenic Transformation with Epithelial-Mesenchymal Transition

(2015) Satoshi Nori et al.   Stem Cell Reports

IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumorsin vivo

(2015) Mythili Koneru et al.   OncoImmunology

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

A phase I clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer

(2013) Kenneth H. Kim et al.   GYNECOLOGIC ONCOLOGY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Perspective: Assembly line immunotherapy

(2013) Bruce L. Levine et al.   NATURE

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

(2013) S. Viaud et al.   SCIENCE

Cell-Based Therapeutics: The Next Pillar of Medicine

(2013) M. A. Fischbach et al.   Science Translational Medicine

Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells

(2013) B. J. Cameron et al.   Science Translational Medicine

World Distribution, Population Genetics, and Health Burden of the Hemoglobinopathies

(2013) T. N. Williams et al.   Cold Spring Harbor Perspectives in Medicine

The Microbiome in Infectious Disease and Inflammation

(2012) Kenya Honda et al.   Annual Review of Immunology

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Innate NK Cells and Macrophages Recognize and Reject Allogeneic Nonself In Vivo via Different Mechanisms

(2012) W. Liu et al.   JOURNAL OF IMMUNOLOGY

Agonistic Antibody to CD40 Boosts the Antitumor Activity of Adoptively Transferred T Cells In Vivo

(2012) Chengwen Liu et al.   JOURNAL OF IMMUNOTHERAPY

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

(2012) J. Scholler et al.   Science Translational Medicine

The allogeneic graft-versus-cancer effect

(2009) Olle Ringdén et al.   BRITISH JOURNAL OF HAEMATOLOGY

Resistance of mature T cells to oncogene transformation

(2008) S. Newrzela et al.   BLOOD