Alpha‐Ketoglutarate Attenuates Colitis in Mice by Increasing Lactobacillus Abundance and Regulating Stem Cell Proliferation via Wnt‐Hippo Signaling

Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

(2021) Álvaro Rol et al.   Nature Communications

Evaluation of Alpha-Ketoglutarate Supplementation on the Improvement of Intestinal Antioxidant Capacity and Immune Response in Songpu Mirror Carp (Cyprinus carpio) After Infection With Aeromonas hydrophila

(2021) Di Wu et al.   Frontiers in Immunology

Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation

(2020) Yexian Yuan et al.   EMBO JOURNAL

Salmonella infection induced intestinal crypt hyperplasia through Wnt/β-catenin pathway in chicken

(2020) Shuang Xie et al.   RESEARCH IN VETERINARY SCIENCE

Lactobacillus reuteri maintains intestinal epithelial regeneration and repairs damaged intestinal mucosa

(2020) Haiqin Wu et al.   Gut Microbes

Dietary L-Tryptophan Regulates Colonic Serotonin Homeostsis in Mice with Dextran Sodium Sulfate-Induced Colitis

(2020) Bin Wang et al.   JOURNAL OF NUTRITION

Cytokine-like Roles for Metabolites in Immunity

(2020) Zbigniew Zasłona et al.   MOLECULAR CELL

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

(2020) Azar Asadi Shahmirzadi et al.   Cell Metabolism

Ulcerative colitis

(2020) Taku Kobayashi et al.   Nature Reviews Disease Primers

CD1d1 intrinsic signaling in macrophages controls NLRP3 inflammasome expression during inflammation

(2020) Shan Cui et al.   Science Advances

The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer

(2019) Yang-An Wen et al.   CELL DEATH AND DIFFERENTIATION

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice

(2019) Graham J. Britton et al.   IMMUNITY

α-ketoglutarate attenuates ischemia-reperfusion injury of liver graft in rats

(2019) Ming-xiang Cheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction

(2019) Jinhua Miao et al.   AGING CELL

Targeting immune cell circuits and trafficking in inflammatory bowel disease

(2019) Markus F. Neurath   NATURE IMMUNOLOGY

Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development

(2019) Juliette Mouries et al.   JOURNAL OF HEPATOLOGY

Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects

(2019) Gabriella Aviello et al.   Mucosal Immunology

Microbial orchestra in juvenile idiopathic arthritis: Sounds of disarray?

(2019) Miika Arvonen et al.   IMMUNOLOGICAL REVIEWS

Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22

(2018) Qihang Hou et al.   CELL DEATH AND DIFFERENTIATION

The Stringent Response Determines the Ability of a Commensal Bacterium to Survive Starvation and to Persist in the Gut

(2018) Whitman B. Schofield et al.   Cell Host & Microbe

YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury

(2018) Feihong Deng et al.   Cell Death & Disease

Hydroxyproline Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice: Involvment of the NF-κB Signaling and Oxidative Stress

(2018) Yun Ji et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Wnt/β-Catenin Signaling as a Potential Target for the Treatment of Liver Cirrhosis Using Antifibrotic Drugs

(2018) Koji Nishikawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

(2018) Arnau Vich Vila et al.   Science Translational Medicine

Gut microbiome structure and metabolic activity in inflammatory bowel disease

(2018) Eric A. Franzosa et al.   Nature Microbiology

CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs

(2017) Danielle A. Chisolm et al.   IMMUNITY

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease

(2017) Aaron Buckley et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial pathway is involved in the protective effects of alpha-ketoglutarate on hydrogen peroxide induced damage to intestinal cells

(2017) Qian Jiang et al.   Oncotarget

Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat

(2016) Daniel B. McKim et al.   BIOLOGICAL PSYCHIATRY

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells

(2016) Tara TeSlaa et al.   Cell Metabolism

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

IBD: In Food We Trust

(2016) Rachel Marion-Letellier et al.   Journal of Crohns & Colitis

Cross-species comparisons of host genetic associations with the microbiome

(2016) Julia K. Goodrich et al.   SCIENCE

Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition

(2016) M. Schwarzer et al.   SCIENCE

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

(2015) Monika Schaubeck et al.   GUT

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection

(2015) Philipp Rausch et al.   PLoS Pathogens

Hippo signaling in epithelial stem cells

(2014) M.-X. Yin et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

The Hippo signaling pathway in stem cell biology and cancer

(2014) J.-S. Mo et al.   EMBO REPORTS

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

(2014) H. Clevers et al.   SCIENCE

Epithelial Barriers, Microbiota, and Colorectal Cancer

(2013) Awen M. Gallimore et al.   NEW ENGLAND JOURNAL OF MEDICINE

Temporal stability of the mouse gut microbiota in relation to innate and adaptive immunity

(2012) Pedro A. Dimitriu et al.   Environmental Microbiology Reports

Glutamine and α-ketoglutarate as glutamate sources for glutathione synthesis in human erythrocytes

(2011) Stephney Whillier et al.   FEBS Journal

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

(2011) Bin Zhao et al.   NATURE CELL BIOLOGY

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

(2011) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the complement and contact systems in the dextran sulfate sodium-induced colitis model: the effect of C1 inhibitor in inflammatory bowel disease

(2010) Fengxin Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Alpha-Ketoglutarate and intestinal function

(2010) Yongqing Hou   Frontiers in Bioscience-Landmark

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

CD4 T-cell differentiation and inflammatory bowel disease

(2009) Lauren A. Zenewicz et al.   TRENDS IN MOLECULAR MEDICINE