期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ijms19103103
关键词
liver fibrosis; Wnt; -catenin; PRI-724
资金
- Japan Agency for Medical Research and Development (AMED) [15fk0210025h003, 16lm0103008j0005, 16im0210105h0001]
Cirrhosis is a form of liver fibrosis resulting from chronic hepatitis and caused by various liver diseases, including viral hepatitis, alcoholic liver damage, nonalcoholic steatohepatitis, and autoimmune liver disease. Cirrhosis leads to various complications, resulting in poor prognoses; therefore, it is important to develop novel antifibrotic therapies to counter liver cirrhosis. Wnt/-catenin signaling is associated with the development of tissue fibrosis, making it a major therapeutic target for treating liver fibrosis. In this review, we present recent insights into the correlation between Wnt/-catenin signaling and liver fibrosis and discuss the antifibrotic effects of the cAMP-response element binding protein/-catenin inhibitor PRI-724.
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