Type I interferon–related kidney disorders

Systemic inflammation and chronic kidney disease in a patient due to the RNASEH2B defect

(2021) Tingyan He et al.   Pediatric Rheumatology

Monogenic Lupus with IgA Nephropathy Caused by Spondyloenchondrodysplasia with Immune Dysregulation

(2021) Haseena Sait et al.   INDIAN JOURNAL OF PEDIATRICS

Collapsing Glomerulopathy as a Complication of Type I Interferon–Mediated Glomerulopathy in a Patient With RNASEH2B-Related Aicardi-Goutières Syndrome

(2021) Paride Fenaroli et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Interferons at the crossroad of cell death pathways during gastrointestinal inflammation and infection

(2021) Iris Stolzer et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency

(2021) Stefano Vavassori et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus

(2021) Johannes Hartl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Augmentation of STING‐induced type I interferon production in COPA syndrome

(2021) Takashi Kato et al.   Arthritis & Rheumatology

Type I Interferons in Systemic Autoimmune Diseases: Distinguishing Between Afferent and Efferent Functions for Precision Medicine and Individualized Treatment

(2021) François Chasset et al.   Frontiers in Pharmacology

IFN-I Mediates Lupus Nephritis From the Beginning to Renal Fibrosis

(2021) Xuewei Ding et al.   Frontiers in Immunology

Monogenic lupus due to DNASE1L3 deficiency in a pediatric patient with urticarial rash, hypocomplementemia, pulmonary hemorrhage, and immune-complex glomerulonephritis

(2021) Rabia Miray Kisla Ekinci et al.   European Journal of Medical Genetics

A multi-center retrospective cohort study defines the spectrum of kidney pathology in Coronavirus 2019 Disease (COVID-19)

(2021) Rebecca M. May et al.   KIDNEY INTERNATIONAL

Plasmacytoid dendritic cells promote acute kidney injury by producing interferon-α

(2020) Bo Deng et al.   Cellular & Molecular Immunology

RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice

(2020) Zhuanli Zhou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Interstitial Lung Disease and Psoriasis in a Child With Aicardi-Goutières Syndrome

(2020) Shaoling Zheng et al.   Frontiers in Immunology

COVAN is the new HIVAN: the re-emergence of collapsing glomerulopathy with COVID-19

(2020) Juan Carlos Q. Velez et al.   Nature Reviews Nephrology

Monogenic lupus due to spondyloenchondrodysplasia with spastic paraparesis and intracranial calcification: case-based review

(2020) Bulent Kara et al.   RHEUMATOLOGY INTERNATIONAL

Parvovirus B19 infection and kidney injury: report of 4 cases and analysis of immunization and viremia in an adult cohort of 100 patients undergoing a kidney biopsy

(2020) Maëlis Kauffmann et al.   BMC Nephrology

Podocytopathies

(2020) Jeffrey B. Kopp et al.   Nature Reviews Disease Primers

Kidney Biopsy Findings in a Critically Ill COVID-19 Patient With Dialysis-Dependent Acute Kidney Injury: A Case Against “SARS-CoV-2 Nephropathy”

(2020) Giovanni Maria Rossi et al.   Kidney International Reports

Case Report: Acute Thrombotic Microangiopathy in a Patient with STING-Associated Vasculopathy with Onset in Infancy (SAVI)

(2020) Mia Ma et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Janus Kinase Inhibition in the Aicardi–Goutières Syndrome

(2020) Adeline Vanderver et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adult-Onset ANCA-Associated Vasculitis in SAVI: Extension of the Phenotypic Spectrum, Case Report and Review of the Literature

(2020) Frederik Staels et al.   Frontiers in Immunology

Type I interferon in the pathogenesis of systemic lupus erythematosus

(2020) Mariana Postal et al.   CURRENT OPINION IN IMMUNOLOGY

APOL1 risk variants and the development of HIV‐associated Nephropathy

(2020) Rohan Goyal et al.   FEBS Journal

Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients

(2020) Marie-Louise Frémond et al.   Journal of Allergy and Clinical Immunology-In Practice

Self-Awareness: Nucleic Acid–Driven Inflammation and the Type I Interferonopathies

(2019) Carolina Uggenti et al.   Annual Review of Immunology

Efficacy of baricitinib in the treatment of chilblains associated with the type I interferonopathy Aicardi-Goutières syndrome

(2019) Kornvalee Meesilpavikkai et al.   Arthritis & Rheumatology

Efficacy and Adverse Events During Janus Kinase Inhibitor Treatment of SAVI Syndrome

(2019) Stefano Volpi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Neutrophil Extracellular Traps (NETs) profiles in patients with incident SLE and lupus nephritis

(2019) Maurizio Bruschi et al.   JOURNAL OF RHEUMATOLOGY

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

(2019) Evan Der et al.   NATURE IMMUNOLOGY

Neutrophil extracellular traps-associated markers are elevated in patients with systemic lupus erythematosus

(2019) Ivica Jeremic et al.   RHEUMATOLOGY INTERNATIONAL

APOL1-Associated Collapsing Focal Segmental Glomerulosclerosis in a Patient With Stimulator of Interferon Genes (STING)-Associated Vasculopathy With Onset in Infancy (SAVI)

(2019) Qassim Abid et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Endothelial expression of fractalkine (CX3CL1) is induced by Toll-like receptor 3 signaling in cultured human glomerular endothelial cells

(2019) Koji Hirono et al.   Modern Rheumatology

Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway

(2019) Shamara E. Davis et al.   Scientific Reports

Trial of Anifrolumab in Active Systemic Lupus Erythematosus

(2019) Eric F. Morand et al.   NEW ENGLAND JOURNAL OF MEDICINE

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2

(2019) Christopher J. A. Duncan et al.   Science Immunology

Changing patterns in clinical–histological presentation and renal outcome over the last five decades in a cohort of 499 patients with lupus nephritis

(2018) Gabriella Moroni et al.   ANNALS OF THE RHEUMATIC DISEASES

Drug-induced lupus: Traditional and new concepts

(2018) Augusto Vaglio et al.   AUTOIMMUNITY REVIEWS

JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies

(2018) Gina A. Montealegre Sanchez et al.   JOURNAL OF CLINICAL INVESTIGATION

Netting Neutrophils Activate Autoreactive B Cells in Lupus

(2018) Nicolas Gestermann et al.   JOURNAL OF IMMUNOLOGY

Whole Exome Sequencing in Early-onset Systemic Lupus Erythematosus

(2018) Ezgi Deniz Batu et al.   JOURNAL OF RHEUMATOLOGY

Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 2 trial

(2018) Daniel J Wallace et al.   LANCET

Donor’s APOL1 Risk Genotype and “Second Hits” Associated With De Novo Collapsing Glomerulopathy in Deceased Donor Kidney Transplant Recipients: A Report of 5 Cases

(2018) Jae-Hyung Chang et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-α in lupus nephritis

(2018) Yuan-yuan Qi et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting TGF-β Signaling in Kidney Fibrosis

(2018) Yoshitaka Isaka   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells

(2018) Samuel W. Du et al.   JOURNAL OF IMMUNOLOGY

Donor APOL1 high-risk genotypes are associated with increased risk and inferior prognosis of de novo collapsing glomerulopathy in renal allografts

(2018) Dominick Santoriello et al.   KIDNEY INTERNATIONAL

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

(2018) Gillian I. Rice et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renal Amyloidosis in Deficiency of Adenosine Deaminase 2: Successful Experience With Canakinumab

(2018) Rabia Miray Kisla Ekinci et al.   PEDIATRICS

Monitoring disease activity in systemic lupus erythematosus with single-molecule array digital ELISA quantification of serum interferon-α

(2018) Alexis Mathian et al.   Arthritis & Rheumatology

Tofacitinib relieves symptoms of stimulator of interferon genes (STING)–associated vasculopathy with onset in infancy caused by 2 de novo variants in TMEM173

(2017) Jieun Seo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The molecular basis for differential type I interferon signaling

(2017) Gideon Schreiber   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of interferon alpha protein reveals differential levels and cellular sources in disease

(2017) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon-inducible Mx1 protein is highly expressed in renal tissues from treatment-naïve lupus nephritis, but not in those under immunosuppressive treatment

(2017) Yuka Shimizu et al.   Modern Rheumatology

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

Clinical Genetic Testing for APOL1 : Are we There Yet?

(2017) Bessie A. Young et al.   SEMINARS IN NEPHROLOGY

Type I interferon-mediated autoinflammation due to DNase II deficiency

(2017) Mathieu P. Rodero et al.   Nature Communications

Autophagy and the Cell Cycle: A Complex Landscape

(2017) Søs Grønbæk Mathiassen et al.   Frontiers in Oncology

Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study

(2016) Munther Khamashta et al.   ANNALS OF THE RHEUMATIC DISEASES

Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature

(2016) D. Kavanagh et al.   BLOOD

Update on Lupus Nephritis

(2016) Salem Almaani et al.   Clinical Journal of the American Society of Nephrology

Clinical-Morphological Features and Outcomes of Lupus Podocytopathy

(2016) W. Hu et al.   Clinical Journal of the American Society of Nephrology

Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173 -activating mutations in 3 children

(2016) Marie-Louise Frémond et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Copa Syndrome: a Novel Autosomal Dominant Immune Dysregulatory Disease

(2016) Timothy J. Vece et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Three cases of spondyloenchondrodysplasia (SPENCD) with systemic lupus erythematosus: a case series and review of the literature

(2016) Y Bilginer et al.   LUPUS

An autosomal recessive DNASE1L3-related autoimmune disease with unusual clinical presentation mimicking systemic lupus erythematosus

(2016) A Carbonella et al.   LUPUS

New insights into the immunopathogenesis of systemic lupus erythematosus

(2016) George C. Tsokos et al.   Nature Reviews Rheumatology

Type I interferonopathies in pediatric rheumatology

(2016) Stefano Volpi et al.   Pediatric Rheumatology

Monogenic polyarteritis: the lesson of ADA2 deficiency

(2016) Roberta Caorsi et al.   Pediatric Rheumatology

Collapsing glomerulopathy in a young woman with APOL1 risk alleles following acute parvovirus B19 infection: a case report investigation

(2016) Whitney Besse et al.   BMC Nephrology

Deficiency of Adenosine Deaminase Type 2: A Description of Phenotype and Genotype in Fifteen Cases

(2016) Sira Nanthapisal et al.   Arthritis & Rheumatology

Cumulative Review of Thrombotic Microangiopathy, Thrombotic Thrombocytopenic Purpura, and Hemolytic Uremic Syndrome Reports with Subcutaneous Interferon β-1a

(2015) Ali-Frédéric Ben-Amor et al.   ADVANCES IN THERAPY

Mutations in DDX58, which Encodes RIG-I, Cause Atypical Singleton-Merten Syndrome

(2015) Mi-Ae Jang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Case Series of Adenosine Deaminase 2-deficient Patients Emphasizing Treatment and Genotype-phenotype Correlations

(2015) E. D. BATU et al.   JOURNAL OF RHEUMATOLOGY

Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1

(2015) Brendan Nichols et al.   KIDNEY INTERNATIONAL

COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis

(2015) Levi B Watkin et al.   NATURE GENETICS

Severe immune dysregulation with neurological impairment and minor bone changes in a child with spondyloenchondrodysplasia due to two novel mutations in the ACP5 gene

(2015) Hermann Girschick et al.   Pediatric Rheumatology

Advances in understanding the role of type I interferons in systemic lupus erythematosus

(2014) Mary K. Crow   CURRENT OPINION IN RHEUMATOLOGY

Localization of APOL1 Protein and mRNA in the Human Kidney: Nondiseased Tissue, Primary Cells, and Immortalized Cell Lines

(2014) L. Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Drug-induced lupus: Including anti-tumour necrosis factor and interferon induced

(2014) S Araújo-Fernández et al.   LUPUS

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

(2014) Gillian I Rice et al.   NATURE GENETICS

Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease

(2014) Helena M. Kok et al.   Nature Reviews Nephrology

Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

(2014) Qing Zhou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutant Adenosine Deaminase 2 in a Polyarteritis Nodosa Vasculopathy

(2014) Paulina Navon Elkan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations in CECR1 associated with a neutrophil signature in peripheral blood

(2014) Alexandre Belot et al.   Pediatric Rheumatology

Interferon-α-induced B-lymphocyte stimulator expression and mobilization in healthy and systemic lupus erthymatosus monocytes

(2014) Patricia López et al.   RHEUMATOLOGY

The Antiviral Cytokines IFN-α and IFN-β Modulate Parietal Epithelial Cells and Promote Podocyte Loss

(2013) Adriana Migliorini et al.   AMERICAN JOURNAL OF PATHOLOGY

DNASE1L3Mutations in Hypocomplementemic Urticarial Vasculitis Syndrome

(2013) Z. Birsin Özçakar et al.   ARTHRITIS AND RHEUMATISM

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

Podocyte Mitosis - A Catastrophe

(2012) L. Lasagni et al.   CURRENT MOLECULAR MEDICINE

Type I IFN Drives a Distinctive Dendritic Cell Maturation Phenotype That Allows Continued Class II MHC Synthesis and Antigen Processing

(2012) D. P. Simmons et al.   JOURNAL OF IMMUNOLOGY

The monocyte chemotactic protein synthesis inhibitor bindarit prevents mesangial cell proliferation and extracellular matrix remodeling

(2012) Sara Paccosi et al.   PHARMACOLOGICAL RESEARCH

Type I interferonopathies: a novel set of inborn errors of immunity

(2011) Yanick J. Crow   Annals of the New York Academy of Sciences

Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway

(2011) B. W. Higgs et al.   ANNALS OF THE RHEUMATIC DISEASES

Binding and activity of all human alpha interferon subtypes

(2011) Thomas B. Lavoie et al.   CYTOKINE

Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature

(2011) Tracy A Briggs et al.   NATURE GENETICS

Genetic deficiency of tartrate-resistant acid phosphatase associated with skeletal dysplasia, cerebral calcifications and autoimmunity

(2011) Ekkehart Lausch et al.   NATURE GENETICS

Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus

(2011) Sulaiman M Al-Mayouf et al.   NATURE GENETICS

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation

(2011) S. Bhattacharyya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment with IFN- , - , or -  Is Associated with Collapsing Focal Segmental Glomerulosclerosis

(2010) G. S. Markowitz et al.   Clinical Journal of the American Society of Nephrology

The Detrimental Effects of IFN-  on Vasculogenesis in Lupus Are Mediated by Repression of IL-1 Pathways: Potential Role in Atherogenesis and Renal Vascular Rarefaction

(2010) S. G. Thacker et al.   JOURNAL OF IMMUNOLOGY

Interferon-α and -β in kidney inflammation

(2010) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid Inhibition

(2010) J. R. Flammer et al.   MOLECULAR AND CELLULAR BIOLOGY

Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages

(2010) A. Triantafyllopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue

(2010) N. Iijima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased viral load after intravenous immunoglobulin therapy for BK virus-associated nephropathy

(2010) U. Maggiore et al.   Transplant Infectious Disease

Type I Interferons Produced by Resident Renal Cells May Promote End-Organ Disease in Autoantibody-Mediated Glomerulonephritis

(2009) A.-M. Fairhurst et al.   JOURNAL OF IMMUNOLOGY

Tracing the Origin of Glomerular Extracapillary Lesions from Parietal Epithelial Cells

(2009) B. Smeets et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal Progenitor Cells Contribute to Hyperplastic Lesions of Podocytopathies and Crescentic Glomerulonephritis

(2009) B. Smeets et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Association of the IRF5 risk haplotype with high serum interferon-α activity in systemic lupus erythematosus patients

(2008) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM

Calcineurin Inhibitors Modulate CXCR3 Splice Variant Expression and Mediate Renal Cancer Progression

(2008) D. Datta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CD4 Binding Affinity Determines Human Immunodeficiency Virus Type 1-Induced Alpha Interferon Production in Plasmacytoid Dendritic Cells

(2008) S. Haupt et al.   JOURNAL OF VIROLOGY

Increased glomerular matrix metalloproteinase activity in murine lupus nephritis

(2008) Anders A. Tveita et al.   KIDNEY INTERNATIONAL

Viruses and Kidney Disease: Beyond HIV

(2008) Meryl Waldman et al.   SEMINARS IN NEPHROLOGY