Metabolic and Growth Rate Alterations in Lymphoblastic Cell Lines Discriminate Between Down Syndrome and Alzheimer’s Disease

Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease

(2017) Charlene Supnet et al.   JOURNAL OF ALZHEIMERS DISEASE

Systemic Mitochondrial Dysfunction and the Etiology of Alzheimer's Disease and Down Syndrome Dementia

(2017) Pinar E. Coskun et al.   JOURNAL OF ALZHEIMERS DISEASE

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

(2016) Heshan Peiris et al.   PLoS Genetics

The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1and Cyclin D1 and induces cell cycle exit and neuronal differentiation

(2014) Ulf Soppa et al.   CELL CYCLE

Strategy to reduce free radical species in Alzheimer’s disease: an update of selected antioxidants

(2014) Fabio Di Domenico et al.   Expert Review of Neurotherapeutics

Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: An overview of Down syndrome, autism, Fragile X and Rett syndrome

(2014) Daniela Valenti et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Redox proteomics and the dynamic molecular landscape of the aging brain

(2013) Marzia Perluigi et al.   AGEING RESEARCH REVIEWS

Abeta, oxidative stress in Alzheimer disease: Evidence based on proteomics studies

(2013) Aaron M. Swomley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Adaptive Downregulation of Mitochondrial Function in Down Syndrome

(2013) Pablo Helguera et al.   Cell Metabolism

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

Atypical aging in down syndrome

(2013) Warren B. Zigman   Developmental Disabilities Research Reviews

Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease

(2013) Gennady Ermak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Nebula/DSCR1 Upregulation Delays Neurodegeneration and Protects against APP-Induced Axonal Transport Defects by Restoring Calcineurin and GSK-3β Signaling

(2013) Jillian L. Shaw et al.   PLoS Genetics

Alzheimer's disease and Down's syndrome: Treating two paths to dementia

(2012) Marc E. Weksler et al.   AUTOIMMUNITY REVIEWS

Lymphocyte respiration in children with Trisomy 21

(2012) Elhadi H Aburawi et al.   BMC Pediatrics

Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers

(2012) A. Attar et al.   BRAIN

Chronic pro-oxidative state and mitochondrial dysfunctions are more pronounced in fibroblasts from Down syndrome foeti with congenital heart defects

(2012) C. Piccoli et al.   HUMAN MOLECULAR GENETICS

Cytosolic Calcium Coordinates Mitochondrial Energy Metabolism with Presynaptic Activity

(2012) A. K. Chouhan et al.   JOURNAL OF NEUROSCIENCE

The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and Disease

(2011) Naval P. Shanware et al.   Annual Review of Pharmacology and Toxicology

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway

(2011) Daniela Valenti et al.   BIOCHEMICAL JOURNAL

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

A mitochondrial etiology of Alzheimer and Parkinson disease

(2011) Pinar Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: Implications for early intervention and therapeutics

(2011) Peizhong Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Calcium uptake mechanisms of mitochondria

(2010) Jaime Santo-Domingo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Adenine nucleotide translocator 1 deficiency increases resistance of mouse brain and neurons to excitotoxic insults

(2009) Jaewon Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome

(2009) Aude-Marie Lepagnol-Bestel et al.   HUMAN MOLECULAR GENETICS

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

Chromosomal Spread Preparation of Human Embryonic Stem Cells for Karyotyping

(2009) Priscila B. Campos et al.   Jove-Journal of Visualized Experiments

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The versatility of mitochondrial calcium signals: From stimulation of cell metabolism to induction of cell death

(2008) Alessandro Rimessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes

(2008) Andrea Canellada et al.   GLIA

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Oxidative stress and cognitive ability in adults with Down syndrome

(2008) Andre Strydom et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE

Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat

(2008) A BLACK et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY