The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1and Cyclin D1 and induces cell cycle exit and neuronal differentiation
出版年份 2014 全文链接
标题
The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1and Cyclin D1 and induces cell cycle exit and neuronal differentiation
作者
关键词
-
出版物
CELL CYCLE
Volume 13, Issue 13, Pages 2084-2100
出版商
Informa UK Limited
发表日期
2014-06-06
DOI
10.4161/cc.29104
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- DYRK1A: A Potential Drug Target for Multiple Down Syndrome Neuropathologies
- (2014) Walter Becker et al. CNS & Neurological Disorders-Drug Targets
- A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr286, not Thr288
- (2013) Anne L. Ashford et al. BIOCHEMICAL JOURNAL
- Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells
- (2013) N. Kurabayashi et al. GENES & DEVELOPMENT
- Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders
- (2013) Takeshi Kawauchi et al. GENES TO CELLS
- Dosage of Dyrk1a Shifts Cells within a p21-Cyclin D1 Signaling Map to Control the Decision to Enter the Cell Cycle
- (2013) Jia-Yun Chen et al. MOLECULAR CELL
- Phenotypic Characterization of Retinoic Acid Differentiated SH-SY5Y Cells by Transcriptional Profiling
- (2013) Joanna A. Korecka et al. PLoS One
- NGF Upregulates the Plasminogen Activation Inhibitor-1 in Neurons via the Calcineurin/NFAT Pathway and the Down Syndrome-Related Proteins DYRK1A and RCAN1 Attenuate This Effect
- (2013) Georgios C. Stefos et al. PLoS One
- Co-ordination of cell cycle and differentiation in the developing nervous system
- (2012) Christopher Hindley et al. BIOCHEMICAL JOURNAL
- Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control
- (2012) Walter Becker CELL CYCLE
- p27Kip1 Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration
- (2012) Juliette D. Godin et al. DEVELOPMENTAL CELL
- TheDYRK1Agene is a cause of syndromic intellectual disability with severe microcephaly and epilepsy
- (2012) Jean-Benoît Courcet et al. JOURNAL OF MEDICAL GENETICS
- Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B
- (2012) Tania Tahtouh et al. JOURNAL OF MEDICINAL CHEMISTRY
- Down syndrome: the brain in trisomic mode
- (2012) Mara Dierssen NATURE REVIEWS NEUROSCIENCE
- DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation
- (2011) Yoshihiko Miyata et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling
- (2011) B. Hammerle et al. DEVELOPMENT
- DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
- (2011) L. Litovchick et al. GENES & DEVELOPMENT
- Homeodomain-interacting Protein Kinase-2 Stabilizes p27kip1by Its Phosphorylation at Serine 10 and Contributes to Cell Motility
- (2011) Giovanna Maria Pierantoni et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Trisomy 21 and early brain development
- (2011) Tarik F. Haydar et al. TRENDS IN NEUROSCIENCES
- MNB/DYRK1A as a multiple regulator of neuronal development
- (2010) Francisco J. Tejedor et al. FEBS Journal
- DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
- (2010) Xiumei Guo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells
- (2010) Joongkyu Park et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dyrk1A Overexpression Inhibits Proliferation and Induces Premature Neuronal Differentiation of Neural Progenitor Cells
- (2010) O. Yabut et al. JOURNAL OF NEUROSCIENCE
- Phosphorylation of p27Kip1 at Thr187 by Cyclin-dependent Kinase 5 Modulates Neural Stem Cell Differentiation
- (2010) Ya-Li Zheng et al. MOLECULAR BIOLOGY OF THE CELL
- Cell cycle control of mammalian neural stem cells: putting a speed limit on G1
- (2010) Paolo Salomoni et al. TRENDS IN CELL BIOLOGY
- Cdk4/CyclinD1 Overexpression in Neural Stem Cells Shortens G1, Delays Neurogenesis, and Promotes the Generation and Expansion of Basal Progenitors
- (2009) Christian Lange et al. Cell Stem Cell
- Function and regulation of Dyrk1A: towards understanding Down syndrome
- (2009) Joongkyu Park et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon
- (2009) Andrea Tedeschi et al. EMBO REPORTS
- Deletion of the p107/p130-binding domain of Mip130/LIN-9 bypasses the requirement for CDK4 activity for the dissociation of Mip130/LIN-9 from p107/p130-E2F4 complex
- (2009) Raudel Sandoval et al. EXPERIMENTAL CELL RESEARCH
- Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation
- (2009) Nora Göckler et al. FEBS Journal
- Mirk Regulates the Exit of Colon Cancer Cells from Quiescence
- (2009) Kideok Jin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alternative Functions of Core Cell Cycle Regulators in Neuronal Migration, Neuronal Maturation, and Synaptic Plasticity
- (2009) Christopher L. Frank et al. NEURON
- Truncation of the Down Syndrome Candidate Gene DYRK1A in Two Unrelated Patients with Microcephaly
- (2008) Rikke S. Møller et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Cyclin D1 and CDK4 Activity Contribute to the Undifferentiated Phenotype in Neuroblastoma
- (2008) J. J. Molenaar et al. CANCER RESEARCH
- A Drug-Inducible System for Direct Reprogramming of Human Somatic Cells to Pluripotency
- (2008) Dirk Hockemeyer et al. Cell Stem Cell
- Post-translational regulation of the tumor suppressor p27KIP1
- (2008) J. Vervoorts et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Transferring genes into cultured mammalian embryos by electroporation
- (2008) Masanori Takahashi et al. DEVELOPMENT GROWTH & DIFFERENTIATION
- The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development
- (2008) Barbara Hämmerle et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine
- (2008) Anne Seifert et al. FEBS Journal
- Retinoic acid downregulates Rae1 leading to APCCdh1 activation and neuroblastoma SH-SY5Y differentiation
- (2008) J Cuende et al. ONCOGENE
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