Article
Clinical Neurology
M. M. Bartley, H. Baer-Benson, D. R. Schroeder, J. L. St Sauver, N. Khera, J. M. Griffin
Summary: Aducanumab is the first FDA-approved immunotherapy for Alzheimer's disease that lowers amyloid levels. The management of amyloid-related imaging abnormalities (ARIA), a potential serious side effect of the treatment, lacks real-world data. In this study, we share our experiences in managing ARIA in patients treated with aducanumab. Six out of 24 participants developed ARIA-E, all of whom were carriers of the APOE-e4 gene. Treatment was discontinued in four cases of moderate-severe ARIA-E, temporarily paused in one moderate case, and continued in one mild case. No hospitalizations or high dose corticosteroids were required. These findings support the use of measured approaches outlined in the Appropriate Use Recommendations.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Amandine Jullienne, Ryan Quan, Jenny Szu, Michelle Trinh, Erik J. Behringer, Andre Obenaus
Summary: This study utilized the 3xTg-AD mouse model to examine the role of vascular dysfunction and structural abnormalities in the progression of Alzheimer's disease. The findings demonstrate progressive alterations in individual cortical vessels and the cortical vascular network, potentially identifying unique diagnostic signatures of AD progression.
Review
Clinical Neurology
Harald Hampel, Aya Elhage, Min Cho, Liana G. Apostolova, James A. R. Nicoll, Alireza Atri
Summary: Excess accumulation and aggregation of toxic amyloid-beta species in the brain is a major characteristic of Alzheimer's disease. This review comprehensively summarizes the radiological features, clinical challenges, pathophysiology, and risk factors associated with amyloid-related imaging abnormalities (ARIA) in relation to anti-amyloid monoclonal antibody treatment.
Review
Endocrinology & Metabolism
Jenny Szu, Andre Obenaus
Summary: Alzheimer's disease is a devastating neurological disorder characterized by memory and cognitive decline, with two main hypotheses proposed regarding its underlying mechanisms. The amyloid hypothesis suggests A beta accumulation as the basis of AD, while the vascular hypothesis links early vascular damage to increased A beta deposits in the brain. Studies have shown significant morphological changes in the cerebrovasculature associated with AD progression, highlighting the need for further research in this area.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Nanoscience & Nanotechnology
Yongjie Xiong, Yi Qu, Zhe Min, Jun Wu, Suming Zhang, Zheng Xue
Summary: This study developed a novel MRI contrast agent by coupling ultrasmall superparamagnetic iron oxide nanoparticles with a functional protein. The contrast agent successfully penetrated biological membranes and bound to Aβ deposits, allowing for the visualization of Aβ deposits in Alzheimer's disease animal models by MRI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Psychiatry
Nady Braidy, Wei Wen, Andre Bongers, Perminder S. Sachdev
Summary: Magnetic Particle Imaging (MPI) is a promising tracer method with high sensitivity and spatial resolution for detecting specific targets and quantifying vascular parameters. Its applications in dementia research, such as detecting abnormal protein deposits and monitoring neural stem cell migration, show great potential for advancement in neurocognitive disorders.
CURRENT OPINION IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Raquel Sanchez-Varo, Marina Mejias-Ortega, Juan Jose Fernandez-Valenzuela, Cristina Nunez-Diaz, Laura Caceres-Palomo, Laura Vegas-Gomez, Elisabeth Sanchez-Mejias, Laura Trujillo-Estrada, Juan Antonio Garcia-Leon, Ines Moreno-Gonzalez, Marisa Vizuete, Javier Vitorica, David Baglietto-Vargas, Antonia Gutierrez
Summary: This review provides an overview of the major pathological elements of Alzheimer's disease and discusses the insights provided by mouse models in understanding the underlying mechanisms. It highlights the pros and cons of current models and explores the potential benefits of combining transgenic mice with omics technologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Nicole Espinosa, Shantel L. Duffy, Haley M. LaMonica, Loren Mowszowski, Ian B. Hickie, Jake R. Palmer, Sharon L. Naismith, Andrew C. McKinnon
Summary: The study investigates the thalamic volumes in older adults with early-onset depression (EOD). It found that individuals with EOD had significantly larger bilateral, right and left hemispheric thalamic volumes compared to the control group. Younger age and lower education level were associated with larger thalamic volumes. However, no significant correlations were found between thalamic volumes and cognitive performance. Further research is needed to understand the underlying mechanisms of these changes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Daiki Nakatsuka, Takaya Izumi, Tasuku Tsukamoto, Miki Oyama, Kohei Nishitomi, Yuichi Deguchi, Kazuki Niidome, Hidekuni Yamakawa, Hisanori Ito, Koichi Ogawa
Summary: Studies suggest that HDAC2 inhibition has disease-modifying effects in treating Alzheimer's disease (AD) and has the potential to slow disease progression. Knockdown of HDAC2 in transgenic mouse models can improve synaptic morphology and memory function.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Anne-Cathrine S. Vogt, Gary T. Jennings, Mona O. Mohsen, Monique Vogel, Martin F. Bachmann
Summary: Alzheimer's disease is the most common form of dementia and is responsible for 60-70% of cases. The number of people with dementia is expected to triple by 2050 due to an aging population. Currently, there are only symptomatic treatments available, making it crucial to develop novel therapeutic strategies to prevent or delay the onset of Alzheimer's disease. This mini-review focuses on the understanding of Alzheimer's disease pathobiology and discusses current immunomodulating therapies targeting amyloid-beta protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Michael S. Rafii, Reisa A. Sperling, Michael C. Donohue, Jin Zhou, Claire Roberts, Michael C. Irizarry, Shobha Dhadda, Gopalan Sethuraman, Lynn D. Kramer, Chad J. Swanson, David Li, Stephen Krause, Robert A. Rissman, Sarah Walter, Rema Raman, Keith A. Johnson, Paul S. Aisen
Summary: The AHEAD 3-45 Study aims to investigate the feasibility of intervention therapy before the clinical symptoms of Alzheimer's disease appear, and utilizes innovative approaches to accelerate the screening process for selecting suitable participants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemical Research Methods
Soumya Kandi, Erika N. Cline, Brianna M. Rivera, Kirsten L. Viola, Jiuhe Zhu, Carlo Condello, Richard D. Leduc, William L. Klein, Neil L. Kelleher, Steven M. Patrie
Summary: This study focuses on the role of different proteoforms of A beta in Alzheimer's disease. The authors evaluated the flux of A beta proteoforms using quantitative top-down mass spectrometry in a mouse model. They found 25 different forms of A beta with differential solubility in addition to the major A beta 1-42 form. These proteoforms were categorized into three groups based on expression levels and solubility. The findings suggest that this workflow has potential for investigating the relationship between insoluble fibrils and soluble A beta, as well as the role of low-molecular-weight oligomers in neurotoxicity. It may also help validate the use of AD-relevant animal models.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Chemistry, Analytical
Shaowei Li, Ziyi Luo, Renlong Zhang, Hao Xu, Ting Zhou, Liwei Liu, Junle Qu
Summary: Alzheimer's disease (AD) is one of the disorders with the highest incidence worldwide due to the increase in the average age of humans, mainly caused by abnormal accumulation of amyloid beta protein (A beta). Distinguishing lesion areas in AD patients through spectroscopy and imaging methods based on coherent anti-Stokes Raman scattering (CARS) can provide a new approach for clinical diagnosis and basic research.
Article
Cell Biology
Chi Him Poon, San Tung Nicholas Wong, Jaydeep Roy, Yingyi Wang, Hui Wang Hujo Chan, Harry Steinbusch, Arjan Blokland, Yasin Temel, Luca Aquili, Lee Wei Lim
Summary: A promising direction in AD research is to identify biomarkers that can better predict cognitive impairment. In this study, neuronal loss was found to be a more accurate predictor compared to amyloid-based biomarkers. Using the 5xFAD mouse model, cognitive impairment was observed to coincide with neuronal loss at 6 months, while amyloid pathology was not present. Additionally, female mice in this model exhibited higher levels of amyloid deposition in the hippocampus and entorhinal cortex, indicating sex-related differences in amyloid pathology.
Article
Cell Biology
Tong Wu, Lizhi Chen, Lingqi Zhou, Jie Xu, Kaihua Guo
Summary: Platelets may play an important role in the pathogenesis of Alzheimer's disease, as their Aβ content increases with age and aged platelets can accelerate Aβ deposition in the brain, leading to learning and memory deficits in recipient mice. Administering aspirin as a platelet activation inhibitor effectively alleviated these toxic processes. In vitro blood-brain barrier models were used to explore the possible cytotoxicity of these platelets.
Article
Radiology, Nuclear Medicine & Medical Imaging
Maarten Naeyaert, Jan Aelterman, Johan Van Audekerke, Vladimir Golkov, Daniel Cremers, Aleksandra Pizurica, Jan Sijbers, Marleen Verhoye
Summary: The study aims to use compressed sensing to accelerate fast spin echo (FSE) imaging for acquiring a high angular resolution diffusion Imaging (HARDI) data set in a time comparable to EPI. Results showed that apparent fiber density and complexity metric had minor differences with q-space undersampling, but deteriorated with k-space undersampling.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Magy Sallam, Mohammed Abderrafi Benotmane, Sarah Baatout, Pieter-Jan Guns, An Aerts
Summary: Radiotherapy in cancer treatment can reduce cancer recurrence and mortality, but may also lead to adverse effects such as radiation-induced cardiovascular disease (CVD). Recent research suggests a potential link between epigenetics and radiation-induced CVD.
Article
Cardiac & Cardiovascular Systems
Hadis Shakeri, Jente R. A. Boen, Sofie De Moudt, Jhana O. Hendrickx, Arthur J. A. Leloup, Griet Jacobs, Guido R. Y. De Meyer, Gilles W. De Keulenaer, Pieter-Jan D. F. Guns, Vincent F. M. Segers
Summary: The study suggests that endothelial cells (ECs) compensate for eNOS deficiency by increasing the secretion of NRG1, which can prevent cardiac and renal hypertrophy and fibrosis caused by ANG II infusion and eNOS deficiency, and its expression is regulated by miR-134.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Paola Perrotta, Margreet R. de Vries, Bart Peeters, Pieter-Jan Guns, Guido R. Y. De Meyer, Paul H. A. Quax, Wim Martinet
Summary: The study shows that deletion of the PFKFB3 gene in ECs can significantly reduce the size of vein graft lesions, IP angiogenesis and hemorrhages, without obvious adverse effects or changes in general metabolism. Additionally, RT-PCR results indicate an increased M2 macrophage signature in vein grafts from mice with EC-specific PFKFB3 deletion.
Article
Biochemistry & Molecular Biology
Jhana O. Hendrickx, Sofie De Moudt, Elke Calus, Wim Martinet, Pieter-Jan D. F. Guns, Lynn Roth, Peter P. De Deyn, Debby Van Dam, Guido R. Y. De Meyer
Summary: Studies have shown that in an AD mouse model, cognitive decline was observed at 12 months, accompanied by systemic insulin resistance and elevated stress hormone levels. These results indicate that peripheral insulin resistance combined with elevated circulating stress hormone levels could be potential biomarkers of the pre-symptomatic phase of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Matthias Bosman, Kasper Favere, Cedric H. G. Neutel, Griet Jacobs, Guido R. Y. De Meyer, Wim Martinet, Emeline M. Van Craenenbroeck, Pieter-Jan D. F. Guns
Summary: This study in mice confirmed that treatment with DOX increases arterial stiffness, with high dose DOX resulting in increased aaPWV and impaired endothelial function leading to elevated vascular tone.
TOXICOLOGY LETTERS
(2021)
Review
Virology
Kasper Favere, Matthias Bosman, Karin Klingel, Stephane Heymans, Sophie Van Linthout, Peter L. Delputte, Johan De Sutter, Hein Heidbuchel, Pieter-Jan Guns
Summary: Myocarditis, an inflammatory disease of the heart often caused by viral infections, poses a significant challenge in clinical management. Toll-like receptors (TLRs) are increasingly recognized for their role in the pathophysiology of viral myocarditis, impacting immune responses and inflammatory reactions throughout the disease process. Future research directions in this field are discussed.
Article
Biochemistry & Molecular Biology
Pauline Puylaert, Isabelle Coornaert, Cedric H. G. Neutel, Yves Dondelinger, Tom Delanghe, Mathieu J. M. Bertrand, Pieter-Jan Guns, Guido R. Y. De Meyer, Wim Martinet
Summary: The study investigates the effects of RIPK1 kinase activity on atherosclerosis and suggests that inhibiting RIPK1 kinase activity accelerates the progression of atherosclerosis.
Article
Biochemistry & Molecular Biology
Pauline Puylaert, Melissa Van Praet, Frederik Vaes, Cedric H. G. Neutel, Lynn Roth, Pieter-Jan Guns, Guido R. Y. De Meyer, Wim Martinet
Summary: GSDMD plays a critical role in atherosclerotic plaque destabilization, with its deficiency leading to increased plaque stability and apoptosis. Targeting GSDMD may be an effective approach to limit the transition to an inflammatory, vulnerable plaque phenotype.
Article
Cardiac & Cardiovascular Systems
Kasper Favere, Jens Van Fraeyenhove, Griet Jacobs, Matthias Bosman, Sander Eens, Johan De Sutter, Hielko Miljoen, Pieter-Jan Guns, Gilles W. De Keulenaer, Vincent F. M. Segers, Hein Heidbuchel
Summary: Cardiac electrophysiology studies in mice, particularly focusing on arrhythmogenesis, provide an opportunity for in-depth evaluation of cardiac electrophysiology. This article provides a comprehensive guide on the technique of murine transjugular EPS, including catheter placement, stimulation protocols, tracing interpretation, and reference values. It aims to increase accessibility and standardization of EPS in mice and contribute to translational research and patient care.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Banafshe Shafieizargar, Ben Jeurissen, Dirk H. J. Poot, Stefan Klein, Johan Van Audekerke, Marleen Verhoye, Arnold J. den Dekker, Jan Sijbers
Summary: This article introduces a novel imaging and parameter estimation framework for accurate multi-shot diffusion MRI. The proposed framework, called ADEPT, enables fast diffusion MRI by allowing diffusion contrast settings to change between shots in a multi-shot EPI acquisition. ADEPT estimates diffusion parameter maps directly from the acquired k-space data and simultaneously accounts for shot-to-shot phase inconsistencies. Simulation and real-data experiments demonstrate that ADEPT provides more accurate and precise estimates of diffusion metrics compared to reference methods.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Magy Sallam, Mohamed Mysara, Mohammed Abderrafi Benotmane, Anne P. G. Crijns, Daan Spoor, Filip Van Nieuwerburgh, Dieter Deforce, Sarah Baatout, Pieter-Jan Guns, An Aerts, Raghda Ramadan
Summary: This study investigates DNA methylation in heart-irradiated rats and radiotherapy-treated breast cancer patients. It finds DNA methylation alterations in the blood of rats and breast cancer patients receiving radiation treatment. Additionally, certain genes' methylation levels show correlations with cardiovascular markers. This study provides clues for understanding the pathophysiology of RICVD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Magy Sallam, Mohamed Mysara, Sarah Baatout, Pieter-Jan Guns, Raghda Ramadan, Mohammed Abderrafi Benotmane
Summary: Glioblastoma is a grade IV glioma with heterogeneous nature. This meta-analysis identified differentially expressed lncRNAs, PCGs, and miRNAs in glioblastoma through RNA-seq and small RNA-seq. Analysis of co-expression correlation networks revealed a functionally relevant sub-cluster involving two novel lncRNAs and two novel PCGs. Pathway analysis showed an association with the novel cell death pathway, ferroptosis, and several glioblastoma-linked pathways. This research confirms the involvement of ferroptosis in glioblastoma pathophysiology and provides potential candidates for further studies.
Article
Peripheral Vascular Disease
Pauline Puylaert, Lynn Roth, Melissa Van Praet, Isabel Pintelon, Catalina Dumitrascu, Alexander van Nuijs, Greta Klejborowska, Pieter-Jan Guns, Tom Vanden Berghe, Koen Augustyns, Guido R. Y. De Meyer, Wim Martinet
Summary: IP angiogenesis is a key feature in the development of atherosclerotic plaques. Erythrophagocytosis-induced ferroptosis during IP angiogenesis leads to larger atherosclerotic plaques, which can be prevented by the ferroptosis inhibitor UAMC-3203.
Article
Biology
Cedric H. G. Neutel, Anne-Sophie Weyns, Arthur Leloup, Sofie De Moudt, Pieter-Jan Guns, Paul Fransen
Summary: This study investigated the effects of physical activity on cardiovascular function in mice and found that vascular smooth muscle cells in the aorta have the ability to de-stiffen or relax after periods of high cyclic stretch. These findings have implications for the therapeutic potential of physical activity in cardiovascular disease.
COMMUNICATIONS BIOLOGY
(2023)
