Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles

Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response after Myocardial Infarction

(2020) Yoav Hadas et al.   CIRCULATION

Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration

(2020) Ajit Magadum et al.   CIRCULATION

Loss of miR-132/212 Has No Long-Term Beneficial Effect on Cardiac Function After Permanent Coronary Occlusion in Mice

(2020) Zhiyong Lei et al.   Frontiers in Physiology

Optimization of 5′ Untranslated Region of Modified mRNA for Use in Cardiac or Hepatic Ischemic Injury

(2020) Nishat Sultana et al.   Molecular Therapy-Methods & Clinical Development

Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology

(2019) Rudolf A. de Boer et al.   EUROPEAN JOURNAL OF HEART FAILURE

Quantitative Assessment of Nanoparticle Biodistribution by Fluorescence Imaging, Revisited

(2018) Fanfei Meng et al.   ACS Nano

Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction

(2018) Kazutaka Miyamoto et al.   Cell Stem Cell

Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine

(2018) Leif Carlsson et al.   Molecular Therapy-Methods & Clinical Development

MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

(2018) Ruchi Jain et al.   Nucleic Acid Therapeutics

Ablation of a single N-glycosylation site in human FSTL1 induces cardiomyocyte proliferation and cardiac regeneration

(2018) Ajit Magadum et al.   Molecular Therapy-Nucleic Acids

mRNA-Based Protein Replacement Therapy for the Heart

(2018) Ajit Magadum et al.   MOLECULAR THERAPY

Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction

(2017) Iris E. Allijn et al.   JOURNAL OF CONTROLLED RELEASE

2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure

(2017) Clyde W. Yancy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Optimizing Cardiac Delivery of Modified mRNA

(2017) Nishat Sultana et al.   MOLECULAR THERAPY

Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics

(2017) James E. Dahlman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased local delivery of antagomir therapeutics to the rodent myocardium using ultrasound and microbubbles

(2016) Rick F.J. Kwekkeboom et al.   JOURNAL OF CONTROLLED RELEASE

Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression

(2016) Irene C Turnbull et al.   MOLECULAR THERAPY

In vivocardiac reprogramming using an optimal single polycistronic construct: Figure 1

(2015) Hong Ma et al.   CARDIOVASCULAR RESEARCH

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Synthetic Chemically Modified mRNA-Based Delivery of Cytoprotective Factor Promotes Early Cardiomyocyte Survival Post-Acute Myocardial Infarction

(2015) Chien-Ling Huang et al.   MOLECULAR PHARMACEUTICS

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

(2015) Gabriele D’Uva et al.   NATURE CELL BIOLOGY

Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model

(2014) Zhiqiang Lin et al.   CIRCULATION RESEARCH

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

(2013) Lior Zangi et al.   NATURE BIOTECHNOLOGY

Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair

(2013) Mei Xin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A contemporary view on endothelial function in heart failure

(2012) Eduard Shantsila et al.   EUROPEAN JOURNAL OF HEART FAILURE

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Biodistribution Studies of Nanoparticles Using Fluorescence Imaging: A Qualitative or Quantitative Method?

(2012) Yang Liu et al.   PHARMACEUTICAL RESEARCH

YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

(2012) A. von Gise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heart regeneration

(2011) Michael A. Laflamme et al.   NATURE

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury

(2009) Kevin Bersell et al.   CELL

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY