Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes

Gene-environment dependencies lead to collider bias in models with polygenic scores

(2021) Evelina T. Akimova et al.   Scientific Reports

The Meaning of “Cause” in Genetics

(2021) Kate E. Lynch   Cold Spring Harbor Perspectives in Medicine

Robust genetic nurture effects on education: A systematic review and meta-analysis based on 38,654 families across 8 cohorts

(2021) Biyao Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders

(2021) Laurie J. Hannigan et al.   PSYCHOLOGICAL MEDICINE

Mendelian Randomization: Concepts and Scope

(2021) Rebecca C. Richmond et al.   Cold Spring Harbor Perspectives in Medicine

Genetic sensitivity analysis: Adjusting for genetic confounding in epidemiological associations

(2021) Jean-Baptiste Pingault et al.   PLoS Genetics

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

(2021) Melinda C. Mills et al.   Nature Human Behaviour

Causal Inference with Genetic Data: Past, Present, and Future

(2021) Jean-Baptiste Pingault et al.   Cold Spring Harbor Perspectives in Medicine

Integrating Family-Based and Mendelian Randomization Designs

(2020) Liang-Dar Hwang et al.   Cold Spring Harbor Perspectives in Medicine

Polygenic Mendelian Randomization

(2020) Frank Dudbridge   Cold Spring Harbor Perspectives in Medicine

Family-Based Designs that Disentangle Inherited Factors from Pre- and Postnatal Environmental Exposures: In Vitro Fertilization, Discordant Sibling Pairs, Maternal versus Paternal Comparisons, and Adoption Designs

(2020) Anita Thapar et al.   Cold Spring Harbor Perspectives in Medicine

Studying individual risk factors for self-harm in the UK Biobank: A polygenic scoring and Mendelian randomisation study

(2020) Kai Xiang Lim et al.   PLOS MEDICINE

Objective and subjective experiences of child maltreatment and their relationships with psychopathology

(2020) Andrea Danese et al.   Nature Human Behaviour

Association between genetic and socioenvironmental risk for schizophrenia during upbringing in a UK longitudinal cohort

(2020) J. B. Newbury et al.   PSYCHOLOGICAL MEDICINE

Associations Between Prenatal Cannabis Exposure and Childhood Outcomes

(2020) Sarah E. Paul et al.   JAMA Psychiatry

Are there causal relationships between attention-deficit/hyperactivity disorder and body mass index? Evidence from multiple genetically informed designs

(2020) Chao-Yu Liu et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

How well can we separate genetics from the environment?

(2020) Jennifer Blanc et al.   eLife

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

(2019) Richard Karlsson Linnér et al.   NATURE GENETICS

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Identification of common genetic risk variants for autism spectrum disorder

(2019) Jakob Grove et al.   NATURE GENETICS

Multi–Polygenic Score Approach to Identifying Individual Vulnerabilities Associated With the Risk of Exposure to Bullying

(2019) Tabea Schoeler et al.   JAMA Psychiatry

Comparing Within- and Between-Family Polygenic Score Prediction

(2019) Saskia Selzam et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Deconstructing the sources of genotype-phenotype associations in humans

(2019) Alexander I. Young et al.   SCIENCE

Childhood Adoption and Mental Health in Adulthood: The Role of Gene-Environment Correlations and Interactions in the UK Biobank

(2019) Kelli Lehto et al.   BIOLOGICAL PSYCHIATRY

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

(2018) Jeanne E. Savage et al.   NATURE GENETICS

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

(2018) James J. Lee et al.   NATURE GENETICS

Using genetic data to strengthen causal inference in observational research

(2018) Jean-Baptiste Pingault et al.   NATURE REVIEWS GENETICS

The nature of nurture: Effects of parental genotypes

(2018) Augustine Kong et al.   SCIENCE

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

(2018) Loic Yengo et al.   HUMAN MOLECULAR GENETICS

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

(2018) Ditte Demontis et al.   NATURE GENETICS

Association of Trauma Type, Age of Exposure, and Frequency in Childhood and Adolescence With Psychotic Experiences in Early Adulthood

(2018) Jazz Croft et al.   JAMA Psychiatry

Collider scope: when selection bias can substantially influence observed associations

(2017) Marcus R Munafò et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Concepts, estimation and interpretation of SNP-based heritability

(2017) Jian Yang et al.   NATURE GENETICS

Widespread covariation of early environmental exposures and trait-associated polygenic variation

(2017) E. Krapohl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study

(2017) Rebecca C. Richmond et al.   PLOS MEDICINE

G = E: What GWAS Can Tell Us about the Environment

(2016) Suzanne H. Gage et al.   PLoS Genetics

Heritability of autism spectrum disorders: a meta-analysis of twin studies

(2015) Beata Tick et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Genomic Heritability: What Is It?

(2015) Gustavo de los Campos et al.   PLoS Genetics

Assessing the Causal Relationship of Maternal Height on Birth Size and Gestational Age at Birth: A Mendelian Randomization Analysis

(2015) Ge Zhang et al.   PLOS MEDICINE

Gene-Environment Dependence Creates Spurious Gene-Environment Interaction

(2014) Frank Dudbridge et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Childhood intelligence is heritable, highly polygenic and associated with FNBP1L

(2013) B Benyamin et al.   MOLECULAR PSYCHIATRY

Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure

(2012) Marcus R. Munafò et al.   JNCI-Journal of the National Cancer Institute

Effects of Adjusting for Instrumental Variables on Bias and Precision of Effect Estimates

(2011) Jessica A. Myers et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry

(2011) Laramie E. Duncan et al.   AMERICAN JOURNAL OF PSYCHIATRY

The heritability of general cognitive ability increases linearly from childhood to young adulthood

(2009) C M A Haworth et al.   MOLECULAR PSYCHIATRY